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FMO3 Gene Trimethylaminuria NGS Genetic Test

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FMO3 Gene Trimethylaminuria NGS Genetic Test

Short Name: Trimethylaminuria NGS Test

Also known as: TMAU, Fish Odor Syndrome

FMO3 Gene Trimethylaminuria NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next Generation Sequencing (NGS) Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Trimethylaminuria by detecting mutations in the FMO3 gene using Next Generation Sequencing (NGS) technology.

Test Code
2263
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide detailed clinical history and undergo genetic counseling before sample collection.

Method: Saliva collection or blood draw

Step 2

Laboratory Analysis

Sample collection involves saliva or blood draw in a sterile environment.

Step 3

Report Delivery

Store sample properly and send to lab promptly.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling and provide medical history.
2
During the Test:Sample collection as per instructions.
3
After the Test:Wait for results and follow up with genetic counseling.

About This Test

Who Should Get This Test

To diagnose Trimethylaminuria by detecting mutations in the FMO3 gene using Next Generation Sequencing (NGS) technology.

How to Prepare

  • Avoid eating or drinking 30 minutes before saliva collection
  • Use provided FTA card for blood drop
  • Label sample correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for the FMO3 gene is crucial for diagnosing Trimethylaminuria, which can cause significant social and psychological distress. Early diagnosis allows for dietary management and counseling, greatly improving quality of life for affected individuals."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood or equivalent
ContainerFTA Card or EDTA tube
Collection MethodSaliva collection or blood draw

Sample Stability

Blood: Stable for 7 days at room temperature
Saliva: Stable for 5 days at 4°C
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed sample
  • Incorrect container

Understanding Your Results

The FMO3 gene test results indicate the presence or absence of mutations associated with Trimethylaminuria.
Normal result: No mutations detected, TMAU unlikely
Abnormal result: Pathogenic mutations found, diagnosis of TMAU likely
Consult a genetic counselor for detailed interpretation
⚠️ When to Consult a Doctor:

If you experience persistent body odor or other symptoms, consult a healthcare provider for evaluation and possible genetic testing.

Limitations

  • ⚠Cannot detect all possible mutations
  • ⚠May not identify mosaicism
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk of bruising from blood draw
  • ●Allergic reaction to antiseptic

Interfering Factors

  • ●DNA degradation
  • ●Sample contamination
  • ●Recent blood transfusion

Compare With Similar Tests

TestFMO3 Gene Trimethylaminuria NGS Genetic Test
ComparisonFMO3 Gene Trimethylaminuria NGS Genetic Test

Frequently Asked Questions

What is Trimethylaminuria (TMAU)?
Trimethylaminuria, also known as Fish Odor Syndrome, is a rare inherited metabolic disorder in which the body is unable to properly break down trimethylamine, a compound produced during digestion. This leads to a strong, persistent fish-like body odor released through sweat, urine, and breath.
What is the FMO3 gene and its role in TMAU?
The FMO3 gene provides instructions for making the flavin-containing monooxygenase 3 enzyme, which is responsible for converting trimethylamine into its odorless form, trimethylamine N-oxide. Mutations in the FMO3 gene impair this enzyme's function, leading to trimethylamine accumulation and the characteristic odor associated with TMAU.
How is TMAU diagnosed through genetic testing?
TMAU is diagnosed through Next Generation Sequencing (NGS) analysis of the FMO3 gene to detect pathogenic mutations. This molecular approach provides a definitive diagnosis by identifying causative variants, distinguishing TMAU from other conditions that may produce similar symptoms.
What are the symptoms of TMAU?
The primary symptom is a persistent, strong fish-like body odor that may fluctuate in intensity. Other symptoms include bad breath, urine with an unusual smell, excessive sweating, and significant psychological impacts such as social anxiety, depression, and isolation due to the stigma associated with the condition.
What is the cost of the FMO3 Gene NGS Genetic Test at DNA Labs India?
The FMO3 Gene Trimethylaminuria NGS Genetic Test at DNA Labs India is priced at INR 20000. This cost includes the complete NGS analysis, report generation, and a genetic counseling session. Free home sample collection is available across India.
How is the sample collected for the test?
The sample can be collected either through a simple saliva collection or a blood draw. For blood collection, an EDTA tube or an FTA card with a single blood drop is used. Home collection services are available where a trained phlebotomist visits your location.
Is fasting required before the test?
No, fasting is not required for this genetic test. However, it is recommended to avoid eating or drinking for at least 30 minutes before saliva collection to ensure sample quality and accurate results.
How long does it take to receive the test results?
The turnaround time for the FMO3 Gene NGS Genetic Test is approximately 3 to 4 weeks from the date of sample collection. Results are delivered through the online portal, email, and WhatsApp for your convenience.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for the FMO3 Gene NGS Genetic Test. Collection is available in multiple cities across India including Mumbai, Delhi, Bangalore, Chennai, Hyderabad, Kolkata, and many more. You can book online to schedule a convenient time.
Can TMAU be treated or managed?
While there is currently no cure for TMAU, symptoms can be effectively managed through dietary modifications that limit intake of trimethylamine precursors such as choline, lecithin, carnitine, and certain seafood. Supplementation with low-dose antibiotics, use of slightly acidic soaps and lotions, and psychological counseling also help improve quality of life.
How accurate is the NGS genetic test for FMO3?
Next Generation Sequencing (NGS) technology provides high accuracy and sensitivity, typically exceeding 99%, for detecting mutations in the FMO3 gene. This advanced technology can identify single nucleotide variants, small insertions and deletions, and other pathogenic changes associated with Trimethylaminuria.
In which cities is the test available?
The FMO3 Gene NGS Genetic Test is available pan-India with home collection services in major cities including Mumbai, Delhi, Bangalore, Chennai, Hyderabad, Kolkata, Pune, Ahmedabad, Jaipur, Lucknow, Chandigarh, and many more. Outstation samples are also accepted.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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