FOXC2 Gene Lymphedema-distichiasis syndrome NGS Genetic Test
Short Name: FOXC2 NGS Test
Also known as: FOXC2 Gene Mutation Test, Lymphedema-distichiasis NGS Panel, FOXC2 Sequencing
FOXC2 Gene Lymphedema-distichiasis syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically available within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to identify pathogenic mutations in the FOXC2 gene that cause lymphedema-distichiasis syndrome. It aids in confirming a clinical diagnosis, differentiating from other lymphedema syndromes, enabling early intervention, and providing information for family planning and genetic counseling.
- Test Code
- 5824
- CPT Code
- 81408
- ICD Code
- Q82.0
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically available within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. Inform your doctor about any medications or supplements. A genetic counseling session is recommended prior to testing.
Method: Venipuncture or finger-prick
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. For FTA card, a finger-prick blood spot is collected. The procedure is quick and minimally invasive.
Report Delivery
You may resume normal activities immediately. The sample will be sent to the laboratory for analysis. Results are typically available in 3-4 weeks.
Timeline: Reports are typically available within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to identify pathogenic mutations in the FOXC2 gene that cause lymphedema-distichiasis syndrome. It aids in confirming a clinical diagnosis, differentiating from other lymphedema syndromes, enabling early intervention, and providing information for family planning and genetic counseling.
How to Prepare
- For blood sample: Use EDTA vacutainer, fill to indicated mark, mix gently
- For FTA card: Apply blood drops to designated circles, air dry for 30 minutes
- Label sample with patient name, date, and unique ID
- Transport at ambient temperature (15-30°C) within 24 hours
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"FOXC2-related lymphedema-distichiasis often presents with lower limb swelling and extra eyelashes. Early genetic confirmation helps guide surveillance for cardiac and venous anomalies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improper labeling
- Sample received after prolonged storage without proper temperature
Understanding Your Results
Positive (Pathogenic variant)
Confirms diagnosis of FOXC2-related lymphedema-distichiasis syndrome. Genetic counseling recommended for family members.
Action: Initiate management for lymphedema, cardiac screening, and ophthalmologic evaluation.
Negative (No pathogenic variant)
No mutation found in FOXC2 gene. Clinical diagnosis may still be considered if symptoms are strong, but other genetic causes should be explored.
Action: Consider broader lymphedema gene panel or referral to specialist.
Variant of Uncertain Significance (VUS)
A genetic variant was found but its clinical significance is unknown. Further testing of family members may help clarify.
Action: Genetic counseling and possible segregation analysis.
Consult a geneticist or specialist if you or a family member have symptoms like unexplained limb swelling, extra eyelashes, or a known family history of lymphedema-distichiasis. Early diagnosis can improve outcomes.
Limitations
- ⚠NGS may not detect large genomic rearrangements or deep intronic variants
- ⚠Variant of uncertain significance (VUS) may require further family studies
- ⚠Test does not assess non-genetic causes of lymphedema
- ⚠Genetic counseling is essential for result interpretation
Risks & Considerations
- ●Minimal risk of bruising or infection at blood draw site
- ●Psychological impact of genetic results
- ●Potential for incidental findings
Interfering Factors
- ●Poor DNA quality or quantity
- ●Contamination during sample collection
- ●Presence of maternal cell contamination in prenatal samples
- ●Rare genetic variants not covered by NGS (e.g., large deletions)
Compare With Similar Tests
| Test | FOXC2 Gene Lymphedema-distichiasis syndrome NGS Genetic Test | Comprehensive Lymphedema Panel | Sanger Sequencing for FOXC2 |
|---|---|---|---|
| Comparison | FOXC2 Gene Lymphedema-distichiasis syndrome NGS Genetic Test |
Frequently Asked Questions
What is FOXC2 gene lymphedema-distichiasis syndrome?
How is the FOXC2 NGS genetic test performed?
What is the cost of the FOXC2 NGS test in India?
How long does it take to get results?
Is fasting required before the test?
Can this test be done on children?
What does a positive result mean?
What if the result is negative?
Is genetic counseling included?
Can I get a home sample collection?
What is the sample type required?
Are there any risks associated with the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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