FSH & LH Stimulation by Gonadotropin Releasing Hormone (GnRH) Test
Short Name: FSH & LH GnRH Stimulation Test
Also known as: GnRH Stimulation Test, Gonadotropin Releasing Hormone Test, FSH LH Stimulation Test
FSH & LH Stimulation by Gonadotropin Releasing Hormone (GnRH) Test test available at DNA Labs India for ₹5,500. Uses Chemiluminescent Immunoassay on Serum samples. Results in Results are typically available within 24 hours after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
This test is designed to evaluate pituitary gland function by assessing how FSH and LH hormones respond to GnRH stimulation. It helps diagnose reproductive endocrine disorders, such as infertility, irregular menstrual cycles, and low testosterone levels, and monitors treatment progress in conditions like central precocious puberty or during GnRH analogue therapy.
- Test Code
- 624
- Price
- ₹5,500
- Sample Type
- Serum
- Result Time
- Results are typically available within 24 hours after sample collection.
- Fasting Required
- Yes (12 hours)
- Method
- Chemiluminescent Immunoassay
Sample Collection
Patient must fast overnight for at least 12 hours. Avoid strenuous activity and inform the doctor about any medications or supplements.
Method: Venous blood draw
Laboratory Analysis
A baseline blood sample is drawn. GnRH is administered intravenously as a bolus. Additional blood samples are collected at 30, 45, and 60 minutes post-injection.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless advised otherwise. Results are typically available within 24 hours.
Timeline: Results are typically available within 24 hours after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
This test is designed to evaluate pituitary gland function by assessing how FSH and LH hormones respond to GnRH stimulation. It helps diagnose reproductive endocrine disorders, such as infertility, irregular menstrual cycles, and low testosterone levels, and monitors treatment progress in conditions like central precocious puberty or during GnRH analogue therapy.
How to Prepare
- Draw fasting baseline specimen from a vein
- Administer GnRH 2.5 ug/kg body weight (100 ug maximum) as IV bolus
- Draw additional specimens at 30, 45, and 60 minutes for FSH and LH
- Ship samples refrigerated or frozen with time markings
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The FSH & LH GnRH stimulation test is a gold standard for evaluating pituitary gonadotropin function, crucial for diagnosing reproductive disorders and monitoring treatment efficacy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic samples
- Improperly labeled containers
- Insufficient sample volume
- Samples not shipped under correct conditions
Understanding Your Results
FSH and LH levels increase 2-5 fold post-stimulation, indicating healthy pituitary function
Minimal or no increase in FSH/LH levels, suggesting pituitary insufficiency or hypothalamic dysfunction
Excessive increase in FSH/LH levels, potentially indicating primary gonadal failure or precocious puberty
Consult an endocrinologist if you experience symptoms like infertility, irregular periods, low libido, or if test results are abnormal. Follow-up may include further hormonal tests or imaging.
Limitations
- ⚠Results may vary based on individual physiology and lab methods
- ⚠Not definitive for all types of reproductive disorders; may require additional tests
- ⚠Contraindicated in cases of known hypersensitivity to GnRH
Risks & Considerations
- ●Minor bruising or pain at the puncture site
- ●Rare allergic reaction to GnRH
- ●Dizziness or lightheadedness
Interfering Factors
- ●Hormonal medications (e.g., birth control pills, testosterone therapy)
- ●Recent GnRH agonist or antagonist use
- ●Acute illness or stress
- ●Timing of the menstrual cycle (if applicable)
Compare With Similar Tests
| Test | FSH & LH Stimulation by Gonadotropin Releasing Hormone (GnRH) Test | Basic FSH and LH Test | GnRH Agonist Test | Clomiphene Citrate Challenge Test |
|---|---|---|---|---|
| Comparison | FSH & LH Stimulation by Gonadotropin Releasing Hormone (GnRH) Test |
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