Fungal Multiplex Detection and Differentiation for Cryptococcus, Stachybotrys, Histoplasma (RNA Detection) Qualitative Test
Short Name: Fungal Multiplex RNA Detection
Also known as: Fungal Multiplex PCR, Cryptococcus/Stachybotrys/Histoplasma RNA Test
Fungal Multiplex Detection and Differentiation for Cryptococcus, Stachybotrys, Histoplasma (RNA Detection) Qualitative Test test available at DNA Labs India for ₹12,750. Uses Real Time PCR, RNA Detection on Blood, BAL, fresh tissue biopsy, skin biopsy, tissue specimens, peripheral blood, respiratory secretions samples. Results in Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect and differentiate Cryptococcus, Stachybotrys, and Histoplasma infections in patients presenting with symptoms such as fever, cough, shortness of breath, and other systemic signs. It is particularly useful for immunocompromised patients, those with unexplained pneumonia, or individuals with potential environmental exposure. The test helps guide targeted antifungal therapy and avoid unnecessary broad-spectrum treatment.
- Test Code
- 6139
- CPT Code
- 87798
- ICD Code
- B49
- Price
- ₹12,750
- Sample Type
- Blood, BAL, fresh tissue biopsy, skin biopsy, tissue specimens, peripheral blood, respiratory secretions
- Result Time
- Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.
- Fasting Required
- No
- Method
- Real Time PCR, RNA Detection
Sample Collection
No special preparation required. However, the patient must sign a consent document and provide relevant clinical history.
Method: Venipuncture or biopsy
Laboratory Analysis
Sample collection is performed by a healthcare professional using sterile techniques. For blood, venipuncture is done; for tissue, biopsy is performed.
Report Delivery
The sample is immediately shipped to the laboratory in appropriate transport media to preserve RNA integrity.
Timeline: Reports are available on the 4th working day. Email reports within 48 hours, phone within 36 hours.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect and differentiate Cryptococcus, Stachybotrys, and Histoplasma infections in patients presenting with symptoms such as fever, cough, shortness of breath, and other systemic signs. It is particularly useful for immunocompromised patients, those with unexplained pneumonia, or individuals with potential environmental exposure. The test helps guide targeted antifungal therapy and avoid unnecessary broad-spectrum treatment.
How to Prepare
- Ensure sample is collected in sterile containers
- For tissue specimens, place in RNA stabilization solution if available
- Label the sample with patient details and date/time of collection
- Transport to laboratory as soon as possible
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"Early and accurate identification of fungal pathogens is critical for effective treatment. This multiplex test helps differentiate among three clinically significant fungi, guiding targeted antifungal therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood samples
- Insufficient sample volume
- Improperly labeled samples
- Samples not transported in appropriate conditions
Understanding Your Results
Cryptococcus RNA Detected
Indicates active Cryptococcus infection, commonly associated with meningitis in immunocompromised patients.
Stachybotrys RNA Detected
Suggests exposure to Stachybotrys chartarum, often linked to moldy environments; may cause respiratory symptoms.
Histoplasma RNA Detected
Indicates Histoplasma capsulatum infection, often seen in endemic areas; may cause pulmonary or disseminated disease.
All Not Detected
No evidence of these three fungal pathogens in the sample; consider other etiologies.
If you have symptoms of fungal infection or have been exposed to high-risk environments, consult your physician. A positive result should be discussed with an infectious disease specialist for appropriate management.
Limitations
- ⚠Qualitative test does not quantify fungal load
- ⚠Negative result does not completely rule out infection if sample is inadequate
- ⚠May not detect all strains or species within the genus
- ⚠Requires careful handling to avoid RNA degradation
Risks & Considerations
- ●Minimal risk of bleeding or infection at collection site
- ●Rare discomfort during venipuncture
Interfering Factors
- ●Improper sample collection or storage may degrade RNA
- ●Presence of PCR inhibitors in the sample
- ●Cross-contamination during processing
- ●Recent antifungal therapy may reduce fungal load
Compare With Similar Tests
| Test | Fungal Multiplex Detection and Differentiation for Cryptococcus, Stachybotrys, Histoplasma (RNA Detection) Qualitative Test | Fungal Culture | Antigen Detection (e.g., Cryptococcal Antigen) | Histopathology |
|---|---|---|---|---|
| Comparison | Fungal Multiplex Detection and Differentiation for Cryptococcus, Stachybotrys, Histoplasma (RNA Detection) Qualitative Test | Culture is slower (days to weeks) and may miss fastidious organisms. Molecular test provides rapid detection and differentiation. | Antigen tests are specific for certain fungi but cannot differentiate multiple species simultaneously. Multiplex RNA test covers three pathogens. | Histopathology requires invasive biopsy and may not identify species. Molecular test offers species-specific identification. |
Frequently Asked Questions
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