GCK Gene Hyperinsulinemic hypoglycemia type 3 NGS Genetic Test
Short Name: GCK HH3 NGS Test
Also known as: HH3 Genetic Test, GCK Mutation Analysis, GCK Gene Sequencing, Hyperinsulinemic Hypoglycemia Type 3 DNA Test
GCK Gene Hyperinsulinemic hypoglycemia type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the GCK Gene HH3 NGS Genetic Test is to identify mutations in the GCK gene responsible for Hyperinsulinemic Hypoglycemia Type 3. This confirms diagnosis, guides treatment decisions, aids in family planning through genetic counseling, and helps in monitoring asymptomatic carriers. It is essential for differentiating HH3 from other causes of hypoglycemia and enabling personalized medical care.
- Test Code
- 2086
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks from sample receipt
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
Ensure genetic counseling session is completed and pedigree chart is drawn. No special dietary preparation required.
Method: Venipuncture or finger prick
Laboratory Analysis
Blood sample collected via venipuncture or finger prick under sterile conditions.
Report Delivery
Sample labeled and transported at ambient temperature to the laboratory. Monitor for any discomfort.
Timeline: 3 to 4 Weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the GCK Gene HH3 NGS Genetic Test is to identify mutations in the GCK gene responsible for Hyperinsulinemic Hypoglycemia Type 3. This confirms diagnosis, guides treatment decisions, aids in family planning through genetic counseling, and helps in monitoring asymptomatic carriers. It is essential for differentiating HH3 from other causes of hypoglycemia and enabling personalized medical care.
How to Prepare
- Use EDTA tube for blood samples
- For FTA card, apply one drop of blood and air dry
- Store at room temperature until shipment
- Avoid freezing or heating the sample
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for GCK gene mutations is crucial for managing HH3, as it guides personalized treatment and family counseling. Always consult a geneticist for interpretation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Clotted blood sample
- Improperly labeled samples
- Contaminated or degraded samples
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of Hyperinsulinemic Hypoglycemia Type 3. Recommend treatment and family screening.
Likely pathogenic variant detected
Strong evidence for HH3. Suggest clinical correlation and genetic counseling.
Variant of uncertain significance (VUS)
Insufficient evidence for pathogenicity. Recommend follow-up testing and monitoring.
Likely benign or benign variant
Unlikely to cause HH3. Consider other diagnostic tests.
No pathogenic variants detected
HH3 not identified via this test. Clinical symptoms may warrant further investigation.
Consult a geneticist or endocrinologist if symptoms of hypoglycemia persist, if a pathogenic variant is detected, or for family planning advice. Seek immediate medical help for severe hypoglycemic episodes like seizures or loss of consciousness.
Limitations
- ⚠May not detect all possible GCK gene mutations
- ⚠Results should be interpreted in clinical context
- ⚠Variants of uncertain significance (VUS) may require further investigation
- ⚠Does not rule out other genetic or non-genetic causes of hypoglycemia
Risks & Considerations
- ●Minor pain or bruising at blood draw site
- ●Very low risk of infection
- ●No significant health risks from the test itself
Interfering Factors
- ●Degraded or contaminated DNA sample
- ●Hemolyzed blood sample
- ●Recent blood transfusion within 120 days
- ●Presence of inhibitors in sample
Compare With Similar Tests
| Test | GCK Gene Hyperinsulinemic hypoglycemia type 3 NGS Genetic Test | Fasting Blood Glucose Test | Insulin Level Measurement | Sanger Sequencing for GCK | Whole Exome Sequencing |
|---|---|---|---|---|---|
| Comparison | GCK Gene Hyperinsulinemic hypoglycemia type 3 NGS Genetic Test |
Frequently Asked Questions
What is Hyperinsulinemic Hypoglycemia Type 3 (HH3)?
What are the common symptoms of HH3?
How is HH3 diagnosed?
What is the GCK Gene HH3 NGS Genetic Test?
How much does the GCK Gene HH3 NGS Genetic Test cost in India?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get results?
Is home sample collection available?
What should I do if my test result is positive?
Are there any risks associated with this test?
How accurate is the NGS genetic test for HH3?
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