GCK Gene Maturity-onset diabetes of the young type 2 NGS Genetic Test
Short Name: GCK MODY Type 2 Genetic Test
Also known as: GCK Gene Sequencing, MODY2 Genetic Test, Glucokinase Gene Test
GCK Gene Maturity-onset diabetes of the young type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the GCK gene for definitive diagnosis of Maturity-onset diabetes of the young type 2 (MODY2). It helps differentiate MODY2 from other diabetes types, guides treatment decisions, and enables family screening for hereditary risk.
- Test Code
- 2145
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt
- Fasting Required
- Yes (8 hours)
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Patient should provide clinical history and undergo genetic counseling. Fasting for 8-12 hours may be required as per physician advice.
Method: Venipuncture or finger-prick
Laboratory Analysis
Blood sample is collected via venipuncture or finger-prick onto an FTA card. Ensure proper labeling and handling.
Report Delivery
Sample is transported to the lab at ambient temperature. Results are available online after 3-4 weeks.
Timeline: 3 to 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the GCK gene for definitive diagnosis of Maturity-onset diabetes of the young type 2 (MODY2). It helps differentiate MODY2 from other diabetes types, guides treatment decisions, and enables family screening for hereditary risk.
How to Prepare
- Fast for 8-12 hours before blood draw if specified
- Avoid strenuous activity prior to collection
- Ensure sample is collected in a sterile environment
- Label sample correctly with patient details
- Store at room temperature and ship promptly
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for MODY type 2 provides a definitive diagnosis, enabling personalized treatment and informing family screening for hereditary diabetes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample hemolysis or contamination
- Insufficient sample volume
- Incorrect sample type or labeling
- Sample stored at improper temperature
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of MODY type 2. Genetic counseling recommended for family screening.
Variant of uncertain significance (VUS)
Further testing or family studies may be needed. Clinical follow-up advised.
No pathogenic variant detected
MODY2 unlikely, but other causes of diabetes should be considered.
Consult a geneticist or endocrinologist immediately after receiving a positive result or if VUS is found, for tailored management and family counseling.
Limitations
- ⚠May not detect all types of genetic variations, such as large deletions or insertions
- ⚠Results are interpretive and require clinical correlation
- ⚠Genetic heterogeneity: MODY2 is caused solely by GCK mutations, but other genes may be involved in similar phenotypes
- ⚠Variant of uncertain significance (VUS) may be identified, requiring further evaluation
Risks & Considerations
- ●Minor bruising or discomfort at blood draw site
- ●Very low risk of infection
- ●Emotional impact of genetic results requiring counseling support
Interfering Factors
- ●Hemolyzed or lipemic blood samples
- ●Contaminated or insufficient DNA extraction
- ●Recent blood transfusions affecting DNA analysis
- ●Sample degradation due to improper storage or transport
Compare With Similar Tests
| Test | GCK Gene Maturity-onset diabetes of the young type 2 NGS Genetic Test | HNF1A Gene MODY3 NGS Test | HNF4A Gene MODY1 NGS Test | Insulin Antibody Test | Fasting Blood Glucose Test |
|---|---|---|---|---|---|
| Comparison | GCK Gene Maturity-onset diabetes of the young type 2 NGS Genetic Test |
Frequently Asked Questions
What is MODY type 2?
Who should consider the GCK gene genetic test?
How is the test performed?
What sample is required?
Is fasting required for the test?
How long does it take to get results?
What does a positive result mean?
What if the result is negative?
Are there any risks to the test?
Is the test covered by insurance?
Can the test be done at home?
How accurate is the test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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