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GIPC3 Gene Deafness, autosomal recessive type 15 NGS Genetic Test

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GIPC3 Gene Deafness, autosomal recessive type 15 NGS Genetic Test

Short Name: GIPC3 Deafness Type 15 Test

Also known as: DFNB15, Autosomal Recessive Deafness 15, GIPC3-related hearing loss

GIPC3 Gene Deafness, autosomal recessive type 15 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

🩺 Medically Reviewed By

Overview

Getting tested for GIPC3 gene mutations helps confirm a diagnosis of DFNB15, understand the genetic basis of hearing loss, assess carrier status for family members, and inform reproductive choices. It provides valuable insights for personalized healthcare and potential interventions.

Test Code
2322
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history of the patient and undergo a genetic counseling session to draw a pedigree chart of family members affected with hearing disorders. Ensure informed consent is obtained.

Method: Venipuncture or saliva collection

Step 2

Laboratory Analysis

A small sample of blood or saliva is collected non-invasively. For blood, venipuncture is performed; for saliva, a swab or container is used. The process is quick and typically painless.

Step 3

Report Delivery

The sample is labeled, stored at ambient room temperature, and transported to the laboratory for analysis. Follow any specific instructions from the healthcare provider.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide complete medical and family history. Genetic counseling is advised to understand implications.
2
During the Test:Sample collection is straightforward; no special procedures required.
3
After the Test:Results are delivered via online portal, email, or WhatsApp. Follow-up with a healthcare provider is recommended.

About This Test

Who Should Get This Test

Getting tested for GIPC3 gene mutations helps confirm a diagnosis of DFNB15, understand the genetic basis of hearing loss, assess carrier status for family members, and inform reproductive choices. It provides valuable insights for personalized healthcare and potential interventions.

How to Prepare

  • Fast for at least 4 hours before blood collection if specified
  • Avoid eating, drinking, or smoking 30 minutes prior to saliva collection
  • Ensure proper identification and consent forms are completed

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for GIPC3 mutations confirms DFNB15 diagnosis, aids in family planning, and guides management for hereditary hearing loss."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per requirement
ContainerEDTA tube for blood, sterile container for saliva
Collection MethodVenipuncture or saliva collection

Sample Stability

Blood: Stable at room temperature for 48 hours
Saliva: Stable at room temperature for 1 week if preserved
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or contaminated blood sample
  • Improperly labeled or stored samples

Understanding Your Results

Results indicate whether pathogenic mutations in the GIPC3 gene are present. A positive result confirms DFNB15 diagnosis, while a negative result may suggest other genetic or environmental causes of hearing loss.
Positive: Pathogenic variant detected – confirms DFNB15; genetic counseling recommended.
Negative: No pathogenic variants – does not rule out other genetic forms of deafness.
Variant of Uncertain Significance (VUS): Further testing or family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a genetic counselor or ENT specialist after receiving results, especially if positive, to discuss management, family planning, and potential interventions such as hearing aids or cochlear implants.

Limitations

  • Does not detect all genetic causes of deafness
  • May identify variants of uncertain significance (VUS)
  • Limited to mutations in the GIPC3 gene only

Risks & Considerations

  • Minor bruising or discomfort at blood collection site
  • Very low risk of infection
  • Potential psychological impact from results

Interfering Factors

  • Sample contamination
  • Degraded DNA quality
  • Improper sample collection or storage

Compare With Similar Tests

TestGIPC3 Gene Deafness, autosomal recessive type 15 NGS Genetic TestGJB2 Gene Deafness TestComprehensive Hearing Loss Panel
ComparisonGIPC3 Gene Deafness, autosomal recessive type 15 NGS Genetic Test

Frequently Asked Questions

What is the GIPC3 Gene Deafness test?
It is a genetic test that uses NGS technology to detect mutations in the GIPC3 gene, causing autosomal recessive deafness type 15 (DFNB15).
Who should consider this test?
Individuals with a family history of deafness, unexplained hearing loss, or balance problems, and those planning for a family with a history of DFNB15.
How is the test performed?
A small blood or saliva sample is collected and analyzed in a lab using next-generation sequencing to identify genetic mutations.
What does a positive result mean?
A positive result confirms a diagnosis of DFNB15, indicating the presence of pathogenic mutations in the GIPC3 gene.
What is the cost of the test?
The test costs INR 20,000 in India, which may include home collection and report delivery.
Is home sample collection available?
Yes, DNA Labs India offers free home collection across many cities in India for online bookings.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is the test covered by insurance?
Generally, genetic tests are not covered by standard insurance schemes in India; check with your provider for specific policies.
What are the symptoms of DFNB15?
Symptoms include mild to severe hearing loss, which may progress over time, and sometimes balance issues.
Can this test detect other causes of deafness?
No, it specifically targets mutations in the GIPC3 gene; other genetic or environmental causes require different tests.
Is genetic counseling recommended?
Yes, genetic counseling before and after testing helps understand results, implications, and family planning.
What should I do after receiving the results?
Consult a healthcare provider or genetic counselor to discuss management options, such as hearing aids, cochlear implants, or family planning.
Is this test suitable for newborns?
Yes, the test can be performed on individuals of all ages, including newborns, to detect early signs of genetic hearing loss.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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Your medical data is protected under Indian law.

Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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