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GJB3 Gene Deafness, autosomal recessive NGS Genetic Test

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GJB3 Gene Deafness, autosomal recessive NGS Genetic Test

Short Name: GJB3 Deafness Test

Also known as: GJB3 gene mutation test, Autosomal recessive deafness genetic test

GJB3 Gene Deafness, autosomal recessive NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-generation sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the GJB3 gene that cause autosomal recessive deafness, enabling early diagnosis, treatment planning, and genetic counseling.

Test Code
2317
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-generation sequencing (NGS)
Step 1

Sample Collection

Provide clinical history of the patient and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Blood draw

Step 2

Laboratory Analysis

Blood sample or extracted DNA is collected via standard venipuncture or using a FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Keep the sample at ambient room temperature.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history assessment are required before testing.
2
During the Test:NGS technology analyzes the GJB3 gene for mutations from the provided sample.
3
After the Test:Results are available in 3 to 4 weeks. Genetic counseling is recommended for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the GJB3 gene that cause autosomal recessive deafness, enabling early diagnosis, treatment planning, and genetic counseling.

How to Prepare

  • Fasting not required
  • Use sterile equipment
  • Label sample correctly
  • Transport sample at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for GJB3 gene deafness aids in accurate diagnosis, management, and genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the GJB3 gene associated with autosomal recessive deafness.
📊

Negative

No pathogenic variants detected in GJB3 gene

Action: Consult a geneticist for further evaluation if symptoms persist

📊

Positive

Pathogenic variant(s) identified in GJB3 gene

Action: Seek genetic counseling and consider family screening

⚠️ When to Consult a Doctor:

If you experience symptoms of hearing loss, have a family history of deafness, or if the test result is positive.

Limitations

  • ⚠Detects only known mutations in the GJB3 gene
  • ⚠May not identify all genetic causes of deafness
  • ⚠Requires genetic counseling for interpretation

Risks & Considerations

  • ●Bruising at the blood draw site
  • ●Rare risk of infection
  • ●Minimal discomfort during sample collection

Interfering Factors

  • ●Poor sample quality
  • ●Contamination
  • ●Improper storage

Frequently Asked Questions

What is GJB3 gene deafness?
GJB3 gene deafness is an autosomal recessive genetic disorder caused by mutations in the GJB3 gene, leading to hearing loss.
How is GJB3 gene deafness inherited?
It is inherited in an autosomal recessive pattern, meaning both parents must carry a mutated gene for a child to be affected.
What are the symptoms of GJB3 gene deafness?
Symptoms include difficulty hearing, delayed speech, tinnitus, sensitivity to loud noises, and trouble hearing in noisy environments.
How is GJB3 gene deafness diagnosed?
Diagnosis involves hearing tests like audiometry and genetic testing such as NGS to analyze the GJB3 gene for mutations.
What is NGS genetic testing?
Next-generation sequencing (NGS) is a high-throughput method used to sequence DNA and identify genetic variants like those in the GJB3 gene.
What is the cost of the GJB3 gene deafness test in India?
The cost at DNA Labs India is INR 20000, which includes home sample collection and comprehensive reporting.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted.
Do I need to fast before the test?
No, fasting is not required for this genetic test.
Can this test detect all causes of deafness?
No, it specifically detects mutations in the GJB3 gene. Other genetic or non-genetic causes may require different tests.
What should I do if I test positive?
If positive, consult a geneticist for counseling, discuss management options, and consider family screening.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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