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DNA Labs India

GLIS3 Gene Diabetes mellitus, neonatal NGS Genetic Test

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GLIS3 Gene Diabetes mellitus, neonatal NGS Genetic Test

Short Name: GLIS3 Neonatal Diabetes NGS Test

Also known as: GLIS3 gene test for neonatal diabetes, Neonatal diabetes genetic panel, GLIS3 mutation analysis

GLIS3 Gene Diabetes mellitus, neonatal NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestNeonatal🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations or alterations in the GLIS3 gene that may cause neonatal diabetes mellitus, enabling early diagnosis, targeted treatment, and genetic counseling for families.

Test Code
4669
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart. No specific fasting required unless advised by physician.

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or using FTA card for one drop of blood. Minimal discomfort expected.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history and draw a pedigree chart. Provide clinical history of the patient.
2
During the Test:Blood sample collection via venipuncture or FTA card. The process is quick and minimally invasive.
3
After the Test:Sample sent for NGS analysis. Reports delivered in 3-4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

To detect mutations or alterations in the GLIS3 gene that may cause neonatal diabetes mellitus, enabling early diagnosis, targeted treatment, and genetic counseling for families.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile collection tubes or FTA cards
  • Label samples accurately with patient details
  • Transport samples at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS test is essential for identifying genetic causes of neonatal diabetes, allowing for targeted treatment and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Sample Stability

Blood or DNA
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed samples
  • Incorrect labeling or missing patient information

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the GLIS3 gene. Positive results suggest a genetic predisposition to neonatal diabetes, while negative results may require further testing if clinical suspicion remains.
📊

Positive for GLIS3 mutation

Confirms genetic cause of neonatal diabetes; recommend genetic counseling and targeted management.

📊

Negative for GLIS3 mutation

No pathogenic variants detected; consider other genetic or environmental factors. Clinical correlation advised.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarity.

⚠️ When to Consult a Doctor:

Consult a doctor if test results are positive, if symptoms persist despite negative results, or for guidance on treatment and family planning.

Limitations

  • ⚠May not detect all types of GLIS3 mutations
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other genetic or environmental causes of diabetes

Risks & Considerations

  • ●Minimal risk from blood draw, such as slight pain or bruising
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results requiring further investigation

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Technical errors in NGS sequencing

Frequently Asked Questions

What is the GLIS3 gene?
The GLIS3 gene is a protein-coding gene that regulates insulin-producing beta cells in the pancreas, crucial for glucose homeostasis.
How is neonatal diabetes diagnosed?
Diagnosis involves clinical symptoms, blood glucose tests, and genetic testing like the GLIS3 NGS test to identify mutations.
What does the NGS Genetic Test involve?
It analyzes DNA from blood or extracted samples using Next-Generation Sequencing to detect mutations in the GLIS3 gene.
Is the test painful?
The test involves a blood draw, which may cause minimal discomfort, but it is generally well-tolerated.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What if the test is positive?
A positive result indicates a genetic mutation linked to neonatal diabetes; genetic counseling and targeted treatment are recommended.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
Is genetic counseling included?
Yes, a genetic counseling session is part of the pre-test information to draw a family pedigree chart.
What are the risks of the test?
Risks are minimal, including slight pain from blood draw and potential psychological impact of results.
How accurate is the test?
The NGS test is highly accurate and reliable for detecting GLIS3 gene mutations, but results should be correlated clinically.
Is the test covered by insurance?
Coverage depends on the insurance provider; it is not typically covered under government schemes like PMJAY or CGHS.
How do I prepare for the test?
Provide clinical history, undergo genetic counseling, and ensure proper sample collection. No fasting is required unless specified.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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