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GPR101 Gene Acromegaly, predisposition to, due to germline GPR101 mutation NGS Genetic Test

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GPR101 Gene Acromegaly, predisposition to, due to germline GPR101 mutation NGS Genetic Test

Short Name: GPR101 Acromegaly Genetic Test

Also known as: GPR101 mutation test for acromegaly, Acromegaly predisposition genetic test, GPR101 gene sequencing test

GPR101 Gene Acromegaly, predisposition to, due to germline GPR101 mutation NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the GPR101 Gene Acromegaly NGS Genetic Test is to identify germline mutations in the GPR101 gene that predispose individuals to acromegaly. This test helps in confirming a genetic diagnosis, assessing risk for family members, guiding personalized treatment strategies, and facilitating genetic counseling for affected families.

Test Code
5362
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree information during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture or a drop of blood on an FTA card. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling to discuss family history and test implications. No fasting or special preparation is required.
2
During the Test:A small blood sample is drawn from a vein in the arm. The procedure takes a few minutes and is performed by a trained phlebotomist.
3
After the Test:You may experience minor bruising at the puncture site. Results will be available in 3-4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of the GPR101 Gene Acromegaly NGS Genetic Test is to identify germline mutations in the GPR101 gene that predispose individuals to acromegaly. This test helps in confirming a genetic diagnosis, assessing risk for family members, guiding personalized treatment strategies, and facilitating genetic counseling for affected families.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile collection equipment
  • Label samples correctly with patient details
  • Transport samples at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for GPR101 mutations is essential for early diagnosis and management of familial acromegaly. Consult an endocrinologist for comprehensive care and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL of blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect labeling or missing information
  • Sample contaminated or degraded

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the GPR101 gene. A positive result confirms genetic predisposition to acromegaly, while a negative result suggests no detectable mutation, though clinical correlation is essential.
📊

Positive for GPR101 mutation

Confirms genetic predisposition to acromegaly. Recommend clinical evaluation, monitoring, and genetic counseling for family members.

📊

Negative for GPR101 mutation

No pathogenic variant detected. Acromegaly may be due to other causes. Further clinical investigation is advised.

📊

Variant of uncertain significance (VUS)

A genetic variant was found, but its clinical significance is unclear. Repeat testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of acromegaly, have a family history of the condition, or receive a positive genetic test result. Early diagnosis and management can prevent complications.

Limitations

  • ⚠Test may not detect all possible mutations in the GPR101 gene
  • ⚠Results require interpretation by a geneticist or endocrinologist
  • ⚠Genetic counseling is recommended before and after testing
  • ⚠Test does not rule out other causes of acromegaly

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising, infection, or dizziness
  • ●Psychological impact of genetic results; genetic counseling recommended

Interfering Factors

  • ●Sample contamination
  • ●Improper sample storage or handling
  • ●Hemolyzed blood sample
  • ●Insufficient DNA quantity

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ComparisonGPR101 Gene Acromegaly, predisposition to, due to germline GPR101 mutation NGS Genetic Test

Frequently Asked Questions

What is acromegaly?
Acromegaly is a rare hormonal disorder where the pituitary gland produces excess growth hormone, leading to abnormal growth of bones and tissues, often in hands, feet, and face.
What is the GPR101 gene?
The GPR101 gene, located on the X chromosome, encodes a receptor involved in regulating growth hormone release. Mutations in this gene can predispose individuals to acromegaly.
Who should consider this genetic test?
Individuals with symptoms of acromegaly, a family history of the condition, or those diagnosed with acromegaly seeking genetic confirmation should consider this test.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) to analyze the entire GPR101 gene from a blood or DNA sample, identifying any mutations.
What does a positive result mean?
A positive result confirms a germline mutation in the GPR101 gene, indicating a genetic predisposition to acromegaly. Genetic counseling and clinical follow-up are recommended.
What if the test is negative?
A negative result means no pathogenic mutation was detected in the GPR101 gene. Acromegaly may still be present due to other causes, so further evaluation is advised.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort or bruising, but it is generally not painful.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What is the cost of the test?
The test costs INR 20,000, which includes sample collection, analysis, and report generation.
Can this test be used for prenatal diagnosis?
This test is designed for postnatal diagnosis. For prenatal concerns, consult a genetic counselor for appropriate testing options.
Is genetic counseling included?
Yes, a genetic counseling session is included to draw a pedigree chart and discuss results and implications.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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