GPR161 Gene Pituitary stalk interruption syndrome, GPR161 related NGS Genetic Test
Short Name: GPR161 Gene PSIS Test
Also known as: PSIS Genetic Test, GPR161 Mutation Analysis
GPR161 Gene Pituitary stalk interruption syndrome, GPR161 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the GPR161 Gene NGS Genetic Test is to identify mutations in the GPR161 gene that may cause Pituitary Stalk Interruption Syndrome, aiding in diagnosis and guiding treatment decisions for hormone deficiencies and related symptoms.
- Test Code
- 2211
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Obtain clinical history of the patient and conduct a genetic counselling session to draw a pedigree chart of family members affected with PSIS.
Method: Standard blood draw or FTA card collection
Laboratory Analysis
Collect blood sample via venipuncture or one drop on FTA card, following standard phlebotomy procedures.
Report Delivery
Label and transport the sample to the laboratory under ambient room temperature conditions for processing.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the GPR161 Gene NGS Genetic Test is to identify mutations in the GPR161 gene that may cause Pituitary Stalk Interruption Syndrome, aiding in diagnosis and guiding treatment decisions for hormone deficiencies and related symptoms.
How to Prepare
- Ensure proper patient identification and consent
- Use sterile collection tubes or FTA cards
- Avoid hemolysis during blood draw
- Store samples at room temperature before transport
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for GPR161 mutations is essential for confirming PSIS diagnosis and informing treatment strategies to manage hormone deficiencies and associated symptoms."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improperly labeled samples
- Contaminated samples
Understanding Your Results
Confirms diagnosis of GPR161-related PSIS; genetic counselling and hormone therapy may be recommended.
Result type: Positive for pathogenic variant
No mutations detected in GPR161; consider other genetic or non-genetic causes of symptoms.
Result type: Negative for pathogenic variant
Additional testing or family studies may be needed for clarification; monitor symptoms and retest if necessary.
Result type: Variant of uncertain significance (VUS)
Consult a doctor if you experience symptoms of PSIS such as growth delays, hormone deficiencies, or if there is a family history of the condition.
Limitations
- ⚠Test may not detect all genetic variants due to technical limitations
- ⚠Results should be interpreted in conjunction with clinical findings
- ⚠Variants of uncertain significance (VUS) may be identified
- ⚠Does not rule out other genetic or non-genetic causes of PSIS
Risks & Considerations
- ●Minimal physical risks from blood draw (e.g., bruising, infection)
- ●Psychological impact of genetic results
- ●Privacy concerns regarding genetic data
Interfering Factors
- ●Sample contamination
- ●Insufficient DNA quantity or quality
- ●Hemolyzed blood samples
- ●Recent blood transfusions
Compare With Similar Tests
| Test | GPR161 Gene Pituitary stalk interruption syndrome, GPR161 related NGS Genetic Test | Hormone Level Testing | MRI Brain | Karyotyping | Whole Exome Sequencing |
|---|---|---|---|---|---|
| Comparison | GPR161 Gene Pituitary stalk interruption syndrome, GPR161 related NGS Genetic Test | Measures hormone levels but does not identify genetic cause; complementary to genetic testing. | Visualizes pituitary anatomy but cannot detect genetic mutations; often used alongside genetic tests. | Analyzes chromosomes but not specific genes like GPR161; used for broader genetic disorders. | Analyzes multiple genes but is more expensive and time-consuming; targeted for PSIS when GPR161 test is negative. |
Frequently Asked Questions
What is GPR161 Gene Pituitary Stalk Interruption Syndrome?
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What is the GPR161-related NGS Genetic Test?
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