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GRIP1 Gene Fraser syndrome NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

GRIP1 Gene Fraser syndrome NGS Genetic Test

Short Name: GRIP1 Fraser Syndrome NGS Test

Also known as: Fraser Syndrome Genetic Test, GRIP1 Mutation Analysis, Fraser Syndrome NGS Test

GRIP1 Gene Fraser syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestPediatrics🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Fraser syndrome by identifying pathogenic mutations in the GRIP1 gene using Next-Generation Sequencing technology.

Test Code
5747
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide detailed clinical history and undergo genetic counseling to draw a pedigree chart.

Method: Venipuncture or saliva collection

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or saliva sample as per instructions.

Step 3

Report Delivery

Sample is processed and sent to the laboratory for NGS analysis.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Genetic counseling recommended to understand the implications of testing.
2
During the Test:Sample collection and laboratory processing for NGS.
3
After the Test:Results interpretation by a geneticist and follow-up counseling.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Fraser syndrome by identifying pathogenic mutations in the GRIP1 gene using Next-Generation Sequencing technology.

How to Prepare

  • Use sterile equipment for blood collection
  • For saliva, follow kit instructions
  • Label samples correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for Fraser syndrome is crucial for management and family planning. This NGS test provides accurate results for informed decision-making."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube for blood
Collection MethodVenipuncture or saliva collection

Sample Stability

Blood samples stable for 7 days at room temperature
Extracted DNA stable for longer periods at -20°C
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Incorrectly labeled samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the GRIP1 gene associated with Fraser syndrome.
Normal: No pathogenic variants detected – Fraser syndrome unlikely
Abnormal: Pathogenic variants detected – Consistent with Fraser syndrome diagnosis
Variant of uncertain significance – Further testing or clinical correlation needed
⚠️ When to Consult a Doctor:

If symptoms of Fraser syndrome are present, or if there is a family history of the disorder, consult a geneticist or obstetrician-gynecologist for evaluation and testing.

Limitations

  • ⚠May not detect all types of mutations in the GRIP1 gene
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw (bruising, infection)
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results requiring further testing

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Hemolyzed blood samples

Compare With Similar Tests

TestGRIP1 Gene Fraser syndrome NGS Genetic TestWhole Exome SequencingTargeted Gene PanelChromosomal Microarray
ComparisonGRIP1 Gene Fraser syndrome NGS Genetic TestMore comprehensive but higher costFocused on specific genes, may miss other causesDetects chromosomal abnormalities, not point mutations

Frequently Asked Questions

What is Fraser syndrome?
Fraser syndrome is a rare genetic disorder that affects the development of eyes, ears, nose, and limbs, caused by mutations in the GRIP1 gene.
What are the symptoms of Fraser syndrome?
Symptoms include eye abnormalities like missing eyelids, ear malformations, nose defects such as cleft palate, and limb abnormalities like webbed fingers.
How is Fraser syndrome diagnosed?
Diagnosis involves physical examination for characteristic features and genetic testing to confirm mutations in the GRIP1 gene.
What is the GRIP1 gene?
The GRIP1 gene is responsible for producing a protein involved in embryonic development; mutations in this gene cause Fraser syndrome.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a high-throughput DNA sequencing technology that can detect mutations in multiple genes simultaneously with high accuracy.
How accurate is the GRIP1 gene NGS test?
The test has high accuracy and specificity for detecting mutations in the GRIP1 gene, but results should be interpreted by a geneticist.
What is the cost of the test?
The GRIP1 Gene Fraser Syndrome NGS Genetic Test costs INR 20,000 at DNA Labs India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the test results mean?
Results indicate whether pathogenic mutations in the GRIP1 gene are detected, which can confirm or rule out Fraser syndrome.
Is genetic counseling necessary before testing?
Yes, genetic counseling is recommended to understand the test implications, results, and family planning options.
Can this test be used for prenatal diagnosis?
Yes, if there is a family history, prenatal testing may be possible, but consult a genetic counselor for options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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