Hains Mycobacterium Tuberculosis Second Line Drug Resistance Profile Test
Short Name: TB Second-Line Resistance Profile Test
Also known as: HAINS TB Second-Line Drug Resistance Test, Mycobacterium Tuberculosis Resistance Profile, TB Second-Line Drug Resistance Assay
Hains Mycobacterium Tuberculosis Second Line Drug Resistance Profile Test test available at DNA Labs India for ₹6,500. Uses PCR, Line probe assay on Sputum, bronchoalveolar lavages, bronchial aspirates, or cultured growth on appropriate media samples. Results in Results available by Friday if sample is submitted by Saturday 11 AM.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
To detect mutations conferring resistance to second-line anti-tuberculosis drugs, aiding in the diagnosis of drug-resistant TB and guiding personalized treatment plans.
- Test Code
- 693
- Price
- ₹6,500
- Sample Type
- Sputum, bronchoalveolar lavages, bronchial aspirates, or cultured growth on appropriate media
- Result Time
- Results available by Friday if sample is submitted by Saturday 11 AM.
- Fasting Required
- No
- Method
- PCR, Line probe assay
Sample Collection
No special preparation is required. Inform the healthcare provider about any medications or recent treatments.
Method: Sputum collection or bronchoscopic procedure
Laboratory Analysis
Collect a sputum sample in the morning or undergo bronchoscopy for lavage/aspirate under medical supervision.
Report Delivery
Ensure the sample is sealed properly and stored refrigerated until pickup for laboratory analysis.
Timeline: Results available by Friday if sample is submitted by Saturday 11 AM.
Patient Instructions
About This Test
Who Should Get This Test
To detect mutations conferring resistance to second-line anti-tuberculosis drugs, aiding in the diagnosis of drug-resistant TB and guiding personalized treatment plans.
How to Prepare
- Collect sputum in the provided sterile container
- Seal the container in the plastic bag to prevent leakage
- Store the sample refrigerated (2-8°C) until collection
- Label the container with patient details and date/time of collection
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"Early detection of second-line drug resistance in tuberculosis is critical for guiding effective treatment regimens and preventing the spread of multidrug-resistant strains."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Samples that are frozen
- Containers that are leaked or improperly sealed
- Specimens with insufficient volume
- Unlabeled or mislabeled samples
Understanding Your Results
Positive for resistance mutation
Likely resistance to the corresponding drug; consult infectious disease specialist for alternative treatment options.
Negative for all tested mutations
Susceptible to the second-line drugs tested; continue with standard regimens as advised.
Indeterminate or error
Repeat testing or use additional diagnostic methods; sample quality may be an issue.
Consult a doctor immediately if the test is positive for drug resistance, or if TB symptoms worsen or persist despite treatment. Also seek advice for treatment planning based on results.
Limitations
- ⚠Detects resistance only to specified second-line drugs; does not cover first-line drugs
- ⚠Requires laboratory expertise and specialized equipment
- ⚠May yield false negatives in samples with very low mycobacterial DNA
- ⚠Not a standalone diagnostic; must be used with clinical and other laboratory findings
Risks & Considerations
- ●Minimal risk from sputum collection; occasional discomfort
- ●Bronchoscopy, if performed, may involve risks like bleeding or infection
- ●No significant risks associated with the test procedure itself
Interfering Factors
- ●Contaminated or improperly collected samples
- ●Low bacterial load in the specimen
- ●Improper storage or transportation conditions
- ●Concurrent use of certain antibiotics may affect results
Compare With Similar Tests
| Test | Hains Mycobacterium Tuberculosis Second Line Drug Resistance Profile Test | GeneXpert MTB/RIF | TB Culture and Drug Susceptibility Testing (DST) | Line Probe Assay (e.g., GenoType MTBDRsl) | Chest X-ray |
|---|---|---|---|---|---|
| Comparison | Hains Mycobacterium Tuberculosis Second Line Drug Resistance Profile Test | Detects Mycobacterium tuberculosis and first-line rifampicin resistance; faster but limited to first-line drugs. | Gold standard for drug resistance profiling; slower (weeks) but comprehensive. | Similar molecular method for second-line resistance; HAINS is a specific technology variant. | Imaging test for TB diagnosis; does not assess drug resistance. |
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