Haptoglobin Genotyping Test
Short Name: Hp Genotyping
Also known as: Hp Genotyping Test, Haptoglobin Polymorphism Test, Haptoglobin Gene Test, Hp 1/2 Genotyping, Haptoglobin Phenotype Test
Haptoglobin Genotyping Test test available at DNA Labs India for ₹6,500. Uses Polymerase Chain Reaction (PCR) on Whole Blood samples. Results in Sample accepted on Tuesday or Saturday (by 11:00 AM). Reports available within 8 working days from the date of sample receipt at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The Haptoglobin Genotyping Test is performed to determine an individual's haptoglobin genotype, which provides valuable information about cardiovascular disease risk, susceptibility to oxidative stress-related complications, and potential disease associations. This test is used for risk stratification in patients with diabetes, those with a family history of coronary artery disease, and individuals undergoing comprehensive genetic health assessments. Identifying the Hp genotype enables physicians to implement personalized preventive strategies and targeted monitoring.
- Test Code
- 692
- CPT Code
- 81250
- ICD Code
- D58.2
- Price
- ₹6,500
- Sample Type
- Whole Blood
- Result Time
- Sample accepted on Tuesday or Saturday (by 11:00 AM). Reports available within 8 working days from the date of sample receipt at the laboratory.
- Fasting Required
- No
- Method
- Polymerase Chain Reaction (PCR)
Sample Collection
No special preparation, fasting, or dietary restrictions are required before sample collection. Inform your physician about any recent blood transfusions, bone marrow transplants, or current medications. Carry a valid doctor's prescription or referral for the test.
Method: Venipuncture
Laboratory Analysis
A qualified phlebotomist will collect approximately 4 mL of venous blood from a vein in your arm using standard venipuncture technique. The blood will be drawn into a Lavender top (EDTA) tube. The procedure typically takes less than 5 minutes and involves minimal discomfort, similar to a routine blood draw.
Report Delivery
After blood collection, gentle pressure will be applied to the puncture site with a cotton ball or gauze for a few minutes. You may resume normal activities immediately. There are no post-collection restrictions. The sample will be transported to the laboratory under refrigerated conditions. Reports will be available within 8 days through the online portal, email, or WhatsApp.
Timeline: Sample accepted on Tuesday or Saturday (by 11:00 AM). Reports available within 8 working days from the date of sample receipt at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The Haptoglobin Genotyping Test is performed to determine an individual's haptoglobin genotype, which provides valuable information about cardiovascular disease risk, susceptibility to oxidative stress-related complications, and potential disease associations. This test is used for risk stratification in patients with diabetes, those with a family history of coronary artery disease, and individuals undergoing comprehensive genetic health assessments. Identifying the Hp genotype enables physicians to implement personalized preventive strategies and targeted monitoring.
How to Prepare
- Ensure the sample is collected in a Lavender top (EDTA) tube only
- A minimum of 2 mL and a recommended volume of 4 mL of whole blood is required
- Ship the sample under refrigerated conditions (2-8°C). Do NOT freeze the sample
- Label the sample correctly with patient details, date, and time of collection
- Inform the laboratory of any recent blood transfusions or bone marrow transplant history
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Haptoglobin genotyping is an increasingly valuable tool in preventive medicine. The Hp 2-2 genotype has been consistently associated with increased oxidative stress and a higher risk of cardiovascular complications, particularly in individuals with diabetes mellitus. Identifying a patient's haptoglobin genotype allows clinicians to implement targeted preventive strategies, including more aggressive cardiovascular risk factor management in Hp 2-2 carriers. I recommend this test for patients with a strong family history of coronary artery disease, those with existing diabetes, or individuals seeking comprehensive genetic risk assessment as part of a preventive health evaluation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received in a non-EDTA tube or incorrect container
- Sample volume less than 2 mL
- Frozen or hemolyzed samples
- Sample older than 1 week from collection date
- Improperly labeled or unlabeled samples
Understanding Your Results
The Hp 1-1 genotype is considered the most favorable in terms of haptoglobin function. It produces small, dimeric haptoglobin with superior hemoglobin-binding and antioxidant capacity. Individuals with this genotype generally have a lower baseline risk of cardiovascular complications, even in the presence of diabetes.
The Hp 2-1 genotype is heterozygous and produces intermediate-sized multimeric haptoglobin. Functional capacity is moderate, placing these individuals at an intermediate level of risk for oxidative stress-related complications. Clinical management should be guided by overall cardiovascular risk profile.
The Hp 2-2 genotype produces large, cyclic multimeric haptoglobin with reduced hemoglobin clearance efficiency and lower antioxidant protection. Research has demonstrated that Hp 2-2 carriers with diabetes mellitus face a significantly increased risk of myocardial infarction, stroke, and cardiovascular mortality. More aggressive cardiovascular risk factor management is recommended for these individuals.
Consult your physician or genetic counselor after receiving your Haptoglobin Genotyping Test results. If you carry the Hp 2-2 genotype, particularly if you have diabetes or a family history of cardiovascular disease, discuss a comprehensive cardiovascular risk management plan with your doctor. Early identification of elevated genetic risk allows for proactive lifestyle modifications and, where appropriate, pharmacological interventions to reduce disease risk.
Limitations
- ⚠This test identifies common haptoglobin genotypes but does not detect rare or novel HP gene variants
- ⚠Genotype determination does not equate to disease diagnosis; clinical correlation is essential
- ⚠The test does not measure serum haptoglobin protein levels, which require separate biochemical testing
- ⚠Results should be interpreted in conjunction with other clinical and laboratory findings by a qualified healthcare provider
- ⚠This test does not assess other genetic or environmental risk factors for cardiovascular disease
Risks & Considerations
- ●Minimal risk associated with a standard venipuncture blood draw
- ●Possible mild bruising or soreness at the puncture site, which resolves within 1-2 days
- ●Rare risk of slight dizziness or lightheadedness during blood collection
- ●No significant procedural risks; the test uses a non-invasive blood sample method
Interfering Factors
- ●Recent blood transfusion within the past 3 months may affect genotyping accuracy
- ●Bone marrow transplant recipients may show donor genotype instead of native genotype
- ●Sample hemolysis or improper storage may compromise DNA extraction quality
- ●Contamination of the blood sample during collection or transport may lead to inconclusive results
Compare With Similar Tests
| Test | Haptoglobin Genotyping Test | Serum Haptoglobin Level | Cardiac Risk Markers Panel | Direct-to-Consumer Genetic Panels |
|---|---|---|---|---|
| Comparison | Haptoglobin Genotyping Test | Serum haptoglobin measures the protein quantity in blood and is used to detect hemolysis. Haptoglobin genotyping determines the genetic variant (Hp 1-1, 2-1, 2-2), which affects protein function and disease risk. Both tests complement each other but serve different clinical purposes. | A cardiac risk panel measures biomarkers like lipid profile, hs-CRP, and homocysteine. Haptoglobin genotyping provides genetic-level risk information. Combining both gives a more complete cardiovascular risk assessment picture. | Broad genetic panels may include haptoglobin variants among hundreds of SNPs but may lack clinical-grade accuracy for this specific gene. Dedicated haptoglobin genotyping via targeted PCR offers higher accuracy and clinical validation for Hp polymorphism detection. |
Frequently Asked Questions
What is the Haptoglobin Genotyping Test?
What is the cost of the Haptoglobin Genotyping Test at DNA Labs India?
Is fasting required before the Haptoglobin Genotyping Test?
What do the different haptoglobin genotypes mean?
Why is haptoglobin genotyping important for diabetic patients?
How is the Haptoglobin Genotyping Test performed?
How long does it take to get the Haptoglobin Genotyping Test results?
Is home sample collection available for the Haptoglobin Genotyping Test?
Can recent blood transfusions affect the Haptoglobin Genotyping Test results?
Is the Haptoglobin Genotyping Test the same as the serum haptoglobin test?
Can the Haptoglobin Genotyping Test diagnose cardiovascular disease?
Does the haptoglobin genotype change over time?
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