Hemochromatosis HFE Full Gene Sequence Analysis Test
Short Name: HFE Gene Analysis
Also known as: HFE Gene Sequencing, Hemochromatosis Genetic Test
Hemochromatosis HFE Full Gene Sequence Analysis Test test available at DNA Labs India for ₹36,000. Uses Sanger Sequencing on Peripheral blood samples. Results in 4-6 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the Hemochromatosis HFE Full Gene Sequence Analysis is to detect mutations in the HFE gene that cause hereditary hemochromatosis. This test helps in confirming diagnosis, assessing risk in family members, guiding treatment decisions, and enabling genetic counseling to manage and prevent iron overload disorders.
- Test Code
- 3026
- Price
- ₹36,000
- Sample Type
- Peripheral blood
- Result Time
- 4-6 weeks
- Fasting Required
- No
- Method
- Sanger Sequencing
Sample Collection
Hemochromatosis HFE Full Gene Sequence Analysis requires a Doctor’s prescription. Prescription is not applicable for surgery, pregnancy cases, or individuals planning to travel abroad.
Method: Venipuncture
Laboratory Analysis
A blood sample is collected via venipuncture from a vein in the arm using standard aseptic techniques.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Keep the area clean and dry.
Timeline: 4-6 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Hemochromatosis HFE Full Gene Sequence Analysis is to detect mutations in the HFE gene that cause hereditary hemochromatosis. This test helps in confirming diagnosis, assessing risk in family members, guiding treatment decisions, and enabling genetic counseling to manage and prevent iron overload disorders.
How to Prepare
- Ensure proper patient identification
- Use an EDTA vacutainer (2ml) for sample collection
- Label the sample correctly with patient details
- Transport the sample in a cool pack to maintain stability
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"As an OB-GYN, I recommend genetic testing for hemochromatosis in patients with a family history or symptoms, as early intervention can prevent complications like liver disease and improve reproductive health outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume
- Incorrect container or labeling
- Sample older than stability period
Understanding Your Results
No mutations detected
Low risk of hereditary hemochromatosis; clinical correlation recommended if symptoms persist
Heterozygous C282Y mutation
Carrier status; may have mild iron overload risk, monitoring advised
Homozygous C282Y mutation
High risk for hemochromatosis; clinical evaluation and treatment like phlebotomy recommended
Other HFE mutations (e.g., H63D, S65C)
Variable risk; genetic counseling and follow-up testing may be needed
Consult a doctor if you experience symptoms of iron overload, have a family history of hemochromatosis, or if test results indicate mutations. Early consultation can guide management and prevent complications.
Limitations
- ⚠May not detect all rare or novel HFE mutations
- ⚠Requires genetic counseling for interpretation
- ⚠Results should be correlated with clinical findings
Risks & Considerations
- ●Minor bruising at the puncture site
- ●Rare risk of infection
- ●Fainting or dizziness during blood draw
Interfering Factors
- ●Hemolyzed blood sample
- ●Contaminated sample
- ●Recent blood transfusion
Compare With Similar Tests
| Test | Hemochromatosis HFE Full Gene Sequence Analysis | Serum Ferritin Test | Transferrin Saturation Test | Liver Biopsy | Genetic Counseling |
|---|---|---|---|---|---|
| Comparison | Hemochromatosis HFE Full Gene Sequence Analysis |
Frequently Asked Questions
What is hemochromatosis?
What is the HFE gene?
Why is the HFE Full Gene Sequence Analysis done?
How is the test performed?
What is the cost of the test in India?
Is home sample collection available?
How long does it take to get results?
Is fasting required for this test?
What are the risks of the test?
Can this test detect all hemochromatosis mutations?
Is the test covered by insurance?
What should I do if my test results are positive?
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