Hepatitis C Viral RNA Genotype 1 NS5a Drug Resistance Test
Short Name: HCV NS5a Drug Resistance Test
Also known as: HCV Genotype 1 NS5a Resistance Test, Hepatitis C Drug Resistance Panel, HCV NS5A Resistance Assay
Hepatitis C Viral RNA Genotype 1 NS5a Drug Resistance Test test available at DNA Labs India for ₹85,000. Uses Polymerase Chain Reaction (PCR), Sequencing on Plasma or Serum samples. Results in 2-3 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
To detect HCV genotype 1 and identify mutations in the NS5A gene associated with resistance to NS5A inhibitors (e.g., daclatasvir, ledipasvir, ombitasvir, elbasvir, velpatasvir) for guiding personalized Hepatitis C treatment.
- Test Code
- 726
- Price
- ₹85,000
- Sample Type
- Plasma or Serum
- Result Time
- 2-3 weeks from sample receipt
- Fasting Required
- No
- Method
- Polymerase Chain Reaction (PCR), Sequencing
Sample Collection
Ensure patient consents and completes Test Send Out Consent Form (Form 35). No specific preparation required.
Method: Venipuncture
Laboratory Analysis
Collect 2 mL of blood via venipuncture in appropriate tube (EDTA or SST).
Report Delivery
Separate plasma or serum aseptically within 8 hours of collection and ship refrigerated or frozen.
Timeline: 2-3 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
To detect HCV genotype 1 and identify mutations in the NS5A gene associated with resistance to NS5A inhibitors (e.g., daclatasvir, ledipasvir, ombitasvir, elbasvir, velpatasvir) for guiding personalized Hepatitis C treatment.
How to Prepare
- Use sterile technique
- Label sample correctly with patient details
- Transport at 2-8°C or frozen on dry ice
- Include completed consent form
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"This test is essential for personalizing HCV treatment, especially with NS5A inhibitors, to ensure efficacy and prevent treatment failure due to drug-resistant strains."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Inadequate sample volume
- Improper container or storage conditions
- Missing or incomplete consent form
Understanding Your Results
HCV Genotype 1 Detected, No NS5A Mutations
Patient likely responds to standard NS5A inhibitor regimens; treatment can proceed as planned.
HCV Genotype 1 Detected with NS5A Mutations
Resistance to certain NS5A inhibitors detected; alternative therapies or combination regimens may be required.
HCV Genotype 1 Not Detected
May indicate non-genotype 1 infection or undetectable virus levels; confirm with additional testing or clinical evaluation.
Consult an infectious disease specialist or hepatologist for interpretation of results and to develop an appropriate treatment plan.
Limitations
- ⚠May not detect all rare resistant variants
- ⚠Results are qualitative or semi-quantitative for resistance
- ⚠Requires accurate patient history for interpretation
- ⚠Not suitable for monitoring viral load
Risks & Considerations
- ●Minor bruising or pain at puncture site
- ●Rare risk of infection
- ●Fainting or dizziness during blood draw
Interfering Factors
- ●Hemolyzed or lipemic samples
- ●Recent blood transfusion or immunoglobulin therapy
- ●Anticoagulant therapy (if not specified)
- ●Improper sample storage or handling
Compare With Similar Tests
| Test | Hepatitis C Viral RNA Genotype 1 NS5a Drug Resistance Test | HCV RNA Quantitative PCR | Hepatitis C Antibody Test | Standard HCV Genotyping Test |
|---|---|---|---|---|
| Comparison | Hepatitis C Viral RNA Genotype 1 NS5a Drug Resistance Test | Measures viral load but not genotype or resistance; used for diagnosis and monitoring. | Detects past or present infection but not active virus or resistance; used for screening. | Identifies HCV genotype but not specific resistance mutations; less comprehensive for treatment guidance. |
Frequently Asked Questions
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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