Hereditary Persistence of Fetal Hemoglobin (HPFH) Test
Short Name: HPFH Test
Also known as: HPFH, Fetal Hemoglobin Persistence, Persistent Fetal Hemoglobin
Hereditary Persistence of Fetal Hemoglobin (HPFH) Test test available at DNA Labs India for ₹6,000. Uses End Point PCR on Amniotic fluid / Chorionic villi / Cord blood samples. Results in Results are typically available within 7-8 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the HPFH test is to diagnose Hereditary Persistence of Fetal Hemoglobin by measuring fetal hemoglobin levels and confirming genetic mutations, aiding in the management of hemoglobin disorders and genetic counseling.
- Test Code
- 3030
- Price
- ₹6,000
- Sample Type
- Amniotic fluid / Chorionic villi / Cord blood
- Result Time
- Results are typically available within 7-8 days after sample collection.
- Fasting Required
- No
- Method
- End Point PCR
Sample Collection
No specific preparation required, but inform the healthcare provider about any medications or recent transfusions.
Method: Venipuncture or specialized collection based on sample type
Laboratory Analysis
Sample collection via venipuncture or specialized procedure for amniotic fluid, chorionic villi, or cord blood, performed by a trained professional.
Report Delivery
Apply pressure to the collection site to prevent bleeding. Resume normal activities unless advised otherwise.
Timeline: Results are typically available within 7-8 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the HPFH test is to diagnose Hereditary Persistence of Fetal Hemoglobin by measuring fetal hemoglobin levels and confirming genetic mutations, aiding in the management of hemoglobin disorders and genetic counseling.
How to Prepare
- Ensure sample is collected in the appropriate sterile container
- Label the sample correctly with patient details
- Transport the sample as per guidelines to maintain stability
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"HPFH testing is essential for diagnosing hemoglobin disorders, especially in families with a history of blood disorders or unexplained anemia, to guide appropriate management and genetic counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample hemolysis or clotting
- Incorrect sample type or container
- Insufficient sample volume
- Improper labeling or transport conditions
Understanding Your Results
HbF level >1%
Suggestive of HPFH; genetic testing recommended for confirmation.
Action: Consult a geneticist or hematologist for further evaluation and counseling.
HbF level within normal range (<1%)
Unlikely HPFH; consider other causes of symptoms.
Action: Discuss with a physician for alternative diagnoses.
Consult a doctor if you have a family history of hemoglobin disorders, experience unexplained anemia or jaundice, or if test results are abnormal for proper diagnosis and management.
Limitations
- ⚠Cannot distinguish between HPFH and other hemoglobin disorders without genetic confirmation
- ⚠May not detect all genetic variants associated with HPFH
- ⚠Results should be interpreted in clinical context by a healthcare professional
Risks & Considerations
- ●Minimal risk from blood draw, such as slight pain, bruising, or infection at the collection site
- ●For amniotic fluid or chorionic villi collection, risks include miscarriage or infection, though rare
Interfering Factors
- ●Recent blood transfusions may affect HbF levels
- ●Certain medications or treatments influencing hemoglobin production
- ●Sample hemolysis or improper storage
Compare With Similar Tests
| Test | Hereditary Persistence of Fetal Hemoglobin (HPFH) | Hemoglobin Electrophoresis | Sickle Cell Solubility Test |
|---|---|---|---|
| Comparison | Hereditary Persistence of Fetal Hemoglobin (HPFH) | Identifies different hemoglobin types but may not specifically diagnose HPFH without genetic testing. | Detects sickle cell disease but not HPFH; used for screening hemoglobin disorders. |
Frequently Asked Questions
What is Hereditary Persistence of Fetal Hemoglobin (HPFH)?
What are the symptoms of HPFH?
How is HPFH diagnosed?
What is the cost of the HPFH test at DNA Labs India?
Is the HPFH test covered by insurance?
How long does it take to get HPFH test results?
Is home sample collection available for the HPFH test?
What samples are required for the HPFH test?
Are there any risks associated with the HPFH test?
How accurate is the HPFH test?
Can HPFH be treated?
Who should get tested for HPFH?
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