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DNA Labs India

HGF Gene Deafness, autosomal recessive type 39 NGS Genetic Test

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HGF Gene Deafness, autosomal recessive type 39 NGS Genetic Test

Short Name: HGF Gene Deafness NGS Test

Also known as: DFNB39 Deafness, HGF Gene Deafness

HGF Gene Deafness, autosomal recessive type 39 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose DFNB39 deafness caused by mutations in the HGF gene through advanced genetic sequencing, facilitating early intervention and genetic counseling.

Test Code
4733
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide detailed clinical and family history. No special preparation required unless specified.

Method: Venipuncture for blood sample or saliva collection

Step 2

Laboratory Analysis

Blood sample will be drawn by a trained phlebotomist using standard venipuncture techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Avoid strenuous activity for a few hours.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Provide clinical history and family pedigree. Genetic counseling is recommended prior to testing.
2
During the Test:Sample collection and processing in the laboratory using NGS technology.
3
After the Test:Results reviewed by a geneticist and reported with interpretation. Follow-up counseling advised.

About This Test

Who Should Get This Test

To diagnose DFNB39 deafness caused by mutations in the HGF gene through advanced genetic sequencing, facilitating early intervention and genetic counseling.

How to Prepare

  • Ensure sample is properly labeled
  • Avoid hemolysis during blood draw
  • Follow instructions for FTA card if used

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of DFNB39 deafness allows for timely intervention, genetic counseling, and informed family planning for at-risk individuals."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture for blood sample or saliva collection

Sample Stability

Blood samples stable at room temperature for 24 hours
Extracted DNA stable for longer periods when stored properly
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Incorrectly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of mutations in the HGF gene associated with DFNB39 deafness.
Positive result: Mutation detected, indicating risk for DFNB39 deafness and need for genetic counseling
Negative result: No mutation detected, but does not rule out other genetic causes of deafness
Variant of uncertain significance: Requires further testing and clinical correlation
⚠️ When to Consult a Doctor:

If you have a family history of deafness, experience progressive hearing loss, or receive a positive genetic test result, consult a geneticist or ENT specialist for further evaluation and management.

Limitations

  • ⚠May not detect all types of mutations (e.g., large deletions)
  • ⚠Requires genetic counseling for interpretation
  • ⚠Not a diagnostic tool for all forms of deafness

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●DNA degradation
  • ●Sample contamination
  • ●Insufficient sample volume

Compare With Similar Tests

TestHGF Gene Deafness, autosomal recessive type 39 NGS Genetic TestGJB2 Gene SequencingSLC26A4 Gene TestOTOF Gene TestComprehensive Hearing Loss Panel
ComparisonHGF Gene Deafness, autosomal recessive type 39 NGS Genetic Test

Frequently Asked Questions

What is the HGF Gene Deafness NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the HGF gene associated with autosomal recessive deafness type 39 (DFNB39).
Who should consider taking this test?
Individuals with progressive hearing loss, family history of deafness, or symptoms suggestive of DFNB39 deafness should consider this test.
How is the test performed?
A blood or saliva sample is collected and analyzed in the lab using NGS technology to identify HGF gene mutations.
What is the cost of the test?
The test costs INR 20,000, which includes home sample collection across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to get results?
Results are typically available within 3-4 weeks after sample collection.
What does a positive result mean?
A positive result indicates the presence of a mutation in the HGF gene, suggesting a risk for DFNB39 deafness and the need for genetic counseling.
Can this test detect all types of deafness?
No, this test specifically targets mutations in the HGF gene. Other genetic causes may require different tests.
Is genetic counseling recommended?
Yes, genetic counseling is highly recommended before and after testing to understand results and implications.
What are the symptoms of DFNB39 deafness?
Symptoms include progressive hearing loss, difficulty understanding speech in noisy environments, tinnitus, and difficulty localizing sounds.
How accurate is the test?
The test uses advanced NGS technology for high accuracy, but results should be interpreted by a qualified geneticist.
What should I do after receiving the results?
Consult a healthcare professional or geneticist for further evaluation, management options, and family planning advice.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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