Hi-C Sequencing Data Analysis Test
Short Name: Hi-C Sequencing Analysis
Also known as: Hi-C Data Analysis, Chromatin Conformation Analysis, 3D Genome Sequencing Analysis
Hi-C Sequencing Data Analysis Test test available at DNA Labs India for ₹50,000. Uses Hi-C Sequencing, Bioinformatics Analysis on Extracted DNA samples. Results in Reports are typically available within 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of Hi-C sequencing data analysis is to map the 3D architecture of the genome and detect structural variants that may underlie genetic disorders. It helps in identifying chromosomal rearrangements, gene fusions, and other aberrations that affect gene expression and disease pathogenesis.
- Test Code
- 6404
- CPT Code
- 81479
- ICD Code
- Z13.89
- Price
- ₹50,000
- Sample Type
- Extracted DNA
- Result Time
- Reports are typically available within 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Hi-C Sequencing, Bioinformatics Analysis
Sample Collection
No special preparation required. However, if blood sample is being collected, inform your doctor about any medications you are taking.
Method: Blood or tissue sample for DNA extraction
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. For tissue samples, a biopsy procedure will be performed by a healthcare professional.
Report Delivery
You can resume normal activities immediately. The sample will be sent to the laboratory for DNA extraction and Hi-C sequencing.
Timeline: Reports are typically available within 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of Hi-C sequencing data analysis is to map the 3D architecture of the genome and detect structural variants that may underlie genetic disorders. It helps in identifying chromosomal rearrangements, gene fusions, and other aberrations that affect gene expression and disease pathogenesis.
How to Prepare
- Ensure the sample is labeled correctly with patient details
- Use EDTA or citrate tube for blood collection
- For extracted DNA, provide concentration and purity information
- Transport samples at 2-8°C if shipping
- Avoid repeated freeze-thaw cycles
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Hi-C sequencing provides a unique view of the 3D genome, enabling detection of structural variants that may be missed by conventional methods. This analysis is particularly valuable for patients with undiagnosed genetic conditions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood samples
- Insufficient DNA quantity (< 1 µg)
- DNA with A260/A280 < 1.8
- Samples not labeled or with incomplete requisition form
Understanding Your Results
No significant structural variants detected
No pathogenic chromosomal rearrangements identified; consider other genetic testing if clinical suspicion remains.
Pathogenic translocation detected
May explain clinical features; genetic counseling recommended for recurrence risk assessment.
Gene fusion identified
May have therapeutic implications, especially in oncology; consult with oncologist for targeted therapy options.
Altered TAD boundaries
May disrupt gene regulation; further functional studies may be needed.
Consult a genetic counselor or healthcare provider if you have a family history of genetic disorders, or if you or your child exhibit symptoms such as developmental delays, intellectual disability, birth defects, unexplained seizures, or autism spectrum disorder.
Limitations
- ⚠May not detect all types of mutations (e.g., point mutations)
- ⚠Requires high-quality DNA and sufficient sequencing depth
- ⚠Interpretation may be limited by reference genome completeness
- ⚠Not a substitute for clinical diagnosis; results should be correlated with phenotype
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●No significant risks associated with the test itself
Interfering Factors
- ●Poor DNA quality or degradation
- ●Insufficient DNA quantity
- ●Contamination with RNA or proteins
- ●Incomplete cross-linking during sample preparation
- ●Sequencing errors or low coverage
Compare With Similar Tests
| Test | Hi-C Sequencing Data Analysis | Karyotyping | Chromosomal Microarray (CMA) | Whole Genome Sequencing (WGS) |
|---|---|---|---|---|
| Comparison | Hi-C Sequencing Data Analysis |
Frequently Asked Questions
What is Hi-C sequencing data analysis?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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