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HLA DSA-SAB Class I IgG Antibodies with C1q Screen Test

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HLA DSA-SAB Class I IgG Antibodies with C1q Screen Test

Short Name: HLA DSA-SAB Class I C1q Test

Also known as: HLA Antibody Test, Donor-Specific Antibody Test, C1q Screen Test

HLA DSA-SAB Class I IgG Antibodies with C1q Screen Test test available at DNA Labs India for ₹38,610. Uses Flow Cytometry, Luminex X-Map technology on Serum samples. Results in 10-12 days from sample collection. Free home collection in 300+ cities across India.

Flow Cytometry🏠 Home Collection

Overview

To detect donor-specific antibodies against HLA Class I antigens in transplant patients, aiding in the diagnosis and management of antibody-mediated rejection.

Test Code
795
Price
₹38,610
Sample Type
Serum
Result Time
10-12 days from sample collection
Fasting Required
No
Method
Flow Cytometry, Luminex X-Map technology
Step 1

Sample Collection

Provide brief clinical history and HLA typing report of the donor if the sample is for pre or post transplantation evaluation.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard venipuncture procedure to collect 2 mL of blood.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding.

Timeline: 10-12 days from sample collection

Patient Instructions

1
Before the Test:Inform the doctor about any medications or recent transfusions. Provide donor HLA typing if available.
2
During the Test:A blood sample will be drawn from a vein in your arm.
3
After the Test:You can resume normal activities immediately after the blood draw.

About This Test

Who Should Get This Test

To detect donor-specific antibodies against HLA Class I antigens in transplant patients, aiding in the diagnosis and management of antibody-mediated rejection.

How to Prepare

  • No fasting required
  • Ensure proper labeling of the sample
  • Ship sample refrigerated or frozen as specified

Doctor's Notes

"This test is essential for early detection of donor-specific antibodies to prevent transplant rejection and guide immunosuppressive therapy."

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (1 mL min.)
ContainerSST (Serum Separator Tube)
Collection MethodVenipuncture

Sample Stability

Room Temperature6 hours
Refrigerator72 hours
Frozen1 week
Sample Rejection Criteria:
  • Insufficient sample volume
  • Improperly stored or shipped samples
  • Missing donor information when required

Understanding Your Results

Results indicate the presence or absence of donor-specific HLA antibodies and their complement-binding capability.
Positive for HLA antibodies: May indicate risk of rejection
Negative for HLA antibodies: Lower risk of antibody-mediated rejection
Positive C1q binding: Antibodies can activate complement, increasing rejection risk
Consult with a transplant specialist for comprehensive interpretation
⚠️ When to Consult a Doctor:

If test results are positive or if symptoms of rejection such as fever, decreased urine output, or graft dysfunction occur.

Limitations

  • Cannot distinguish between HLA and non-HLA antibodies without additional testing
  • May require correlation with clinical history
  • Test sensitivity may vary based on assay conditions

Risks & Considerations

  • Minimal risk: slight pain or bruising at the puncture site
  • Rare: infection or dizziness

Interfering Factors

  • Hemolyzed or lipemic samples
  • Recent blood transfusions
  • Presence of other cross-reactive antibodies

Compare With Similar Tests

TestHLA DSA-SAB Class I IgG Antibodies with C1q Screen Test
ComparisonHLA DSA-SAB Class I IgG Antibodies with C1q Screen TestDetects antibodies against Class II HLA antigensMeasures overall sensitization level

Frequently Asked Questions

What is the HLA DSA-SAB Class I IgG Antibodies with C1q Screen Test?
This test detects donor-specific antibodies against HLA Class I antigens in transplant patients, including their complement-binding capability, to assess rejection risk.
Why is this test recommended for transplant patients?
It is recommended to monitor for antibody-mediated rejection, which can lead to graft failure if not detected and managed early.
How is the test performed?
A blood sample is collected and analyzed using flow cytometry and Luminex X-Map technology to identify HLA antibodies and C1q binding.
What does a positive result mean?
A positive result indicates the presence of donor-specific antibodies, which may require closer monitoring or adjusted immunosuppressive therapy.
What is the cost of the test at DNA Labs India?
The cost is INR 38610.0, with free home sample collection available across India.
How long does it take to get the results?
Results are typically available within 10-12 days after sample collection.
Is fasting required before the test?
No, fasting is not required for this test.
Can the test be done at home?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What are the symptoms that may indicate the need for this test?
Symptoms like fever, fatigue, nausea, vomiting, or abdominal pain in transplant patients may suggest antibody-mediated rejection.
How accurate is the test?
The test is highly sensitive and specific, using advanced techniques to reliably detect HLA antibodies and C1q binding.
What is the difference between this test and other HLA antibody tests?
This test includes C1q binding assessment, distinguishing complement-activating antibodies from non-complement-binding ones, which is critical for rejection risk evaluation.
Who should interpret the test results?
Results should be interpreted by a transplant specialist, such as a nephrologist or hematologist, in conjunction with clinical history and other diagnostics.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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