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DNA Labs India

HLA DSA-SAB Class II IgG Antibodies with C1q Screen Test

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HLA DSA-SAB Class II IgG Antibodies with C1q Screen Test

Also known as: HLA DSA-SAB Class II Antibody Test, C1q Screen for HLA Antibodies

HLA DSA-SAB Class II IgG Antibodies with C1q Screen Test test available at DNA Labs India for ₹40,000. Uses Luminex X-Map Technology on Serum samples. Results in 10-12 days. Free home collection in 300+ cities across India.

Immunological AssayAdults🏠 Home Collection

✍️ Written By

Overview

This assay is used for the detection of pre and post transplantation HLA antibodies in Solid Organ Transplant recipients and in unmatched Bone Marrow Transplants. It detects antibodies against HLA antigens including HLA-DRB1, DQA1, DQB1, DPA1, and DPB1. Additionally, C1q distinguishes complement binding antibodies from non-complement binding antibodies, aiding in risk stratification for rejection.

Test Code
811
Price
₹40,000
Sample Type
Serum
Result Time
10-12 days
Fasting Required
No
Method
Luminex X-Map Technology
Step 1

Sample Collection

Provide clinical history and donor HLA typing reports if available. No fasting required.

Method: Venipuncture

Step 2

Laboratory Analysis

A small blood sample is drawn from a vein in the arm.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 10-12 days

Patient Instructions

1
Before the Test:No special preparation needed. Provide necessary clinical documents.
2
During the Test:Blood sample collection via venipuncture; quick and minimally invasive.
3
After the Test:Mild soreness at the puncture site may occur. Results will be shared via preferred method.

About This Test

Who Should Get This Test

This assay is used for the detection of pre and post transplantation HLA antibodies in Solid Organ Transplant recipients and in unmatched Bone Marrow Transplants. It detects antibodies against HLA antigens including HLA-DRB1, DQA1, DQB1, DPA1, and DPB1. Additionally, C1q distinguishes complement binding antibodies from non-complement binding antibodies, aiding in risk stratification for rejection.

How to Prepare

  • Provide brief clinical history
  • Submit HLA typing report of donor/donors if pre or post transplantation sample
  • Ensure sample is collected in SST tube

Doctor's Notes

"This test is critical for assessing compatibility and monitoring rejection in transplant patients. Early detection of complement-binding antibodies can guide treatment to improve graft survival."

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (1 mL min.)
ContainerSST (Serum Separator Tube)
Collection MethodVenipuncture

Sample Stability

Room Temperature: 6 hours
Refrigerator: 72 hours
Frozen: 1 week
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect sample type

Understanding Your Results

Results indicate the presence and specificity of HLA antibodies. Positive results suggest increased risk of rejection, especially if complement-binding.
Negative result: Low risk of antibody-mediated rejection
Positive result: Higher risk; further evaluation needed
C1q positive: Indicates complement-binding antibodies with higher rejection potential
Consult transplant team for management based on titer and clinical context
⚠️ When to Consult a Doctor:

If you experience symptoms like fever, pain over the transplant site, decreased urine output, swelling, shortness of breath, high blood pressure, abdominal pain, nausea, or vomiting after a transplant, seek immediate medical attention.

Limitations

  • ⚠May not detect all antibody subclasses
  • ⚠Results should be interpreted with clinical context
  • ⚠False negatives possible in low-titer cases

Risks & Considerations

  • ●Minor bruising or pain at puncture site
  • ●Rare risk of infection or dizziness

Interfering Factors

  • ●Hemolyzed or lipemic samples
  • ●Recent blood transfusions
  • ●Immunosuppressive therapy may affect antibody levels

Frequently Asked Questions

What is the HLA DSA-SAB Class II IgG Antibodies with C1q Screen test?
It is a blood test that detects donor-specific antibodies against HLA Class II antigens and identifies complement-binding antibodies, helping assess transplant rejection risk.
Why is this test important for transplant patients?
It helps evaluate compatibility before transplant and monitor for rejection after, guiding treatment to improve graft survival.
What is the cost of this test at DNA Labs India?
The test costs INR 40,000, and home sample collection is available across India.
Is this test covered by insurance?
No, it is not typically covered by insurance; patients usually pay out of pocket.
How is the test performed?
A blood sample is drawn from your arm and analyzed using Luminex X-Map technology in the laboratory.
What are the symptoms of transplant rejection that this test helps diagnose?
Symptoms include fever, pain over the transplant site, decreased urine output, swelling, shortness of breath, high blood pressure, abdominal pain, nausea, and vomiting.
How long does it take to get results?
Results are available within 10-12 days after sample collection.
What sample is required for the test?
2 mL of serum from a blood sample collected in an SST tube.
Do I need to fast before the test?
No, fasting is not required for this test.
What is the significance of the C1q screen?
The C1q screen distinguishes complement-binding antibodies, which are more likely to cause rejection, from non-complement-binding ones.
Can this test be done after a transplant?
Yes, it is used both before and after transplantation to monitor antibody levels and rejection risk.
Where is this test available?
DNA Labs India offers this test with free home sample collection in numerous cities across India, including Mumbai, Delhi, Bangalore, and more.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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