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HLA Hypersensitivity to Abacavir (B*57:01) Test

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HLA Hypersensitivity to Abacavir (B*57:01) Test

Short Name: HLA-B*57:01 Test

Also known as: HLA-B*57:01 Genotyping, Abacavir Hypersensitivity Test, HLA Hypersensitivity Test

HLA Hypersensitivity to Abacavir (B*57:01) Test test available at DNA Labs India for ₹8,000. Uses Polymerase Chain Reaction (PCR), DNA Sequencing on Whole blood or Buccal swab samples. Results in 10-12 days. Free home collection in 300+ cities across India.

Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To determine if an individual carries the HLA-B*57:01 allele, indicating a risk for hypersensitivity to Abacavir, thereby guiding safer treatment decisions for HIV patients.

Test Code
812
Price
₹8,000
Sample Type
Whole blood or Buccal swab
Result Time
10-12 days
Fasting Required
No
Method
Polymerase Chain Reaction (PCR), DNA Sequencing
Step 1

Sample Collection

No special preparation required. Inform healthcare provider about any medications or medical conditions.

Method: Venipuncture or buccal swab

Step 2

Laboratory Analysis

Blood drawn from vein or buccal swab collected from inside the cheek.

Step 3

Report Delivery

Apply pressure to the puncture site if blood drawn. Resume normal activities.

Timeline: 10-12 days

Patient Instructions

1
Before the Test:No fasting required. Discuss any concerns with your doctor.
2
During the Test:A simple blood draw or cheek swab; takes a few minutes.
3
After the Test:No downtime. Resume normal activities.

About This Test

Who Should Get This Test

To determine if an individual carries the HLA-B*57:01 allele, indicating a risk for hypersensitivity to Abacavir, thereby guiding safer treatment decisions for HIV patients.

How to Prepare

  • Ensure proper identification
  • Use aseptic technique
  • Label sample correctly
  • Transport as per stability guidelines

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Testing for HLA-B*57:01 is standard of care before initiating Abacavir to avoid potentially life-threatening hypersensitivity reactions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or Buccal swab
Sample Volume4 mL or 6 mL for blood; swab for buccal
ContainerEDTA tube, ACD tube, or sterile container
Collection MethodVenipuncture or buccal swab

Sample Stability

Room Temperature: Not stable
Refrigerator: 96 hours
Frozen: Not recommended
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient volume
  • Improperly labeled sample
  • Contaminated swab

Understanding Your Results

The presence of the HLA-B*57:01 allele indicates a high risk for hypersensitivity to Abacavir.
📊

HLA-B*57:01 Detected

High risk for Abacavir hypersensitivity. Avoid Abacavir and use alternative HIV medications.

📊

HLA-B*57:01 Not Detected

Low risk, but hypersensitivity cannot be entirely ruled out. Monitor for symptoms during treatment.

⚠️ When to Consult a Doctor:

If you experience symptoms like fever, rash, or respiratory issues after taking Abacavir, consult your doctor immediately.

Limitations

  • ⚠A negative result does not completely rule out hypersensitivity to Abacavir
  • ⚠Does not detect other drug hypersensitivities
  • ⚠Limited to HLA-B*57:01 allele only
  • ⚠Results should be interpreted in clinical context

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Infection risk (very low)
  • ●Allergic reaction to swab material (rare)

Interfering Factors

  • ●Sample contamination
  • ●Improper storage conditions
  • ●Recent blood transfusion
  • ●Genetic variants not covered by the test

Compare With Similar Tests

TestHLA Hypersensitivity to Abacavir (B*57:01) TestHLA-A*31:01 Test for Carbamazepine HypersensitivityHLA-B*15:02 Test for Carbamazepine Hypersensitivity
ComparisonHLA Hypersensitivity to Abacavir (B*57:01) Test

Frequently Asked Questions

What is the HLA Hypersensitivity to Abacavir (B*57:01) Test?
It is a genetic test that checks for the HLA-B*57:01 allele, which indicates a higher risk of hypersensitivity reactions to Abacavir, an HIV medication.
Why is this test necessary before taking Abacavir?
To prevent severe allergic reactions that can be life-threatening, ensuring safer treatment for HIV patients.
What are the symptoms of Abacavir hypersensitivity?
Symptoms include fever, rash, nausea, vomiting, abdominal pain, shortness of breath, cough, and swollen glands. Severe cases can lead to anaphylaxis.
How is the test performed?
A blood sample or buccal swab is collected and analyzed using PCR and sequencing to detect the HLA-B*57:01 gene.
What is the cost of the test in India?
The test costs INR 8000 at DNA Labs India, with home collection available in many cities.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India.
How long does it take to receive the results?
Results are typically available within 10-12 days.
What should I do if the test is positive?
If positive, avoid Abacavir and consult your doctor for alternative HIV medications.
Can a negative test result guarantee no hypersensitivity?
No, a negative result reduces the risk but does not eliminate it entirely. Clinical monitoring is still recommended.
Are there any risks associated with the test?
The test itself has minimal risks, such as slight bruising from blood draw or rare allergic reactions to swab materials.
Is the test covered by insurance?
Coverage varies; it is advisable to check with your insurance provider. DNA Labs India offers the test at a discounted price.
Who should consider taking this test?
All HIV-positive patients before starting Abacavir therapy, and those with a history of drug hypersensitivity.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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