HNF1A Gene Maturity-onset diabetes of the young type 3 NGS Genetic Test
Short Name: HNF1A MODY3 NGS Test
Also known as: HNF1A Gene Test, MODY3 Genetic Test, MODY Type 3 NGS Test
HNF1A Gene Maturity-onset diabetes of the young type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3-4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect mutations in the HNF1A gene to confirm a diagnosis of Maturity-onset diabetes of the young type 3 (MODY3), enabling personalized treatment, family risk assessment, and appropriate management to prevent diabetes-related complications.
- Test Code
- 2150
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are typically available within 3-4 weeks after sample collection.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Provide clinical history of the patient and undergo a genetic counseling session to draw a pedigree chart of family members affected with MODY3.
Method: Blood draw or Saliva collection
Laboratory Analysis
Sample collection via blood draw or saliva as per standard protocol in a sterile environment.
Report Delivery
Apply pressure to the puncture site for blood collection; store the sample as per laboratory guidelines for transport.
Timeline: Results are typically available within 3-4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect mutations in the HNF1A gene to confirm a diagnosis of Maturity-onset diabetes of the young type 3 (MODY3), enabling personalized treatment, family risk assessment, and appropriate management to prevent diabetes-related complications.
How to Prepare
- Bring clinical history and family medical records
- Ensure proper identification and labeling of the sample
- Follow any specific preparation instructions from the healthcare provider
- Consider genetic counseling before or after the test
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Genetic testing for MODY3 can guide personalized treatment plans, inform family screening, and improve long-term diabetes management outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic blood sample
- Insufficient sample volume
- Improperly labeled or contaminated sample
- Sample received without proper documentation
Understanding Your Results
Positive (Pathogenic Variant Detected)
Confirms diagnosis of MODY3; enables targeted treatment and family screening.
Negative (No Pathogenic Variant)
No mutation in HNF1A gene; consider other genetic tests if clinical suspicion remains.
Variant of Uncertain Significance
Further evaluation and family studies recommended; may not be diagnostic.
Consult a geneticist or endocrinologist if the test is positive for mutation to discuss management options, or if negative but symptoms persist for further diagnostic workup.
Limitations
- ⚠May not detect all possible mutations in the HNF1A gene
- ⚠Results may include variants of uncertain significance
- ⚠Cannot rule out other genetic causes of diabetes
- ⚠Interpretation requires clinical correlation and genetic counseling
Risks & Considerations
- ●Minimal risk from blood draw, such as slight pain or bruising
- ●Potential psychological impact of genetic results
- ●Risk of variants of uncertain significance causing anxiety
Interfering Factors
- ●Sample degradation or contamination
- ●Improper sample collection or storage
- ●Hemolyzed blood sample
- ●Previous blood transfusions (for DNA-based tests)
Compare With Similar Tests
| Test | HNF1A Gene Maturity-onset diabetes of the young type 3 NGS Genetic Test | ||||
|---|---|---|---|---|---|
| Comparison | HNF1A Gene Maturity-onset diabetes of the young type 3 NGS Genetic Test | GCK test identifies mutations in the GCK gene causing MODY2, which has milder symptoms and often requires no treatment. | HNF4A test detects mutations causing MODY1, which may have similar symptoms but different treatment responses. | Insulin gene test is for neonatal diabetes, not typically for MODY3. | NGS can analyze multiple genes simultaneously, while Sanger sequencing is targeted but may miss other variants. |
Frequently Asked Questions
What is the HNF1A Gene MODY3 NGS Genetic Test?
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