HRAS Gene Costello syndrome NGS Genetic Test
Short Name: HRAS Gene Test
Also known as: Costello Syndrome Genetic Test, HRAS Mutation Analysis, RASopathy Genetic Test
HRAS Gene Costello syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the HRAS Gene Costello Syndrome NGS Genetic Test is to identify pathogenic mutations in the HRAS gene that cause Costello syndrome. This test aids in definitive diagnosis, differential diagnosis from other RASopathies, and informs clinical management, including surveillance for cancer and cardiac issues. It also supports genetic counseling for recurrence risk assessment in families.
- Test Code
- 5733
- Price
- ₹20,000
- Sample Type
- Blood, Extracted DNA, or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Provide clinical history of the patient and undergo a genetic counseling session to draw a pedigree chart of family members affected with Costello syndrome or related conditions.
Method: Venipuncture for blood samples
Laboratory Analysis
A blood sample will be collected via venipuncture, or an extracted DNA sample or FTA card with one drop of blood can be used.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store the sample as per instructions and transport to the lab promptly.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the HRAS Gene Costello Syndrome NGS Genetic Test is to identify pathogenic mutations in the HRAS gene that cause Costello syndrome. This test aids in definitive diagnosis, differential diagnosis from other RASopathies, and informs clinical management, including surveillance for cancer and cardiac issues. It also supports genetic counseling for recurrence risk assessment in families.
How to Prepare
- Ensure proper identification of the patient
- Use sterile collection tubes
- Label samples accurately with patient details
- Follow standard phlebotomy procedures
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic diagnosis of Costello syndrome allows for timely intervention and management of associated health risks. Genetic counseling is recommended for affected families to understand inheritance patterns and recurrence risks."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improper labeling or documentation
Understanding Your Results
Positive for pathogenic HRAS mutation
Confirms diagnosis of Costello syndrome. Recommend clinical management, cancer surveillance, and genetic counseling.
Negative for pathogenic HRAS mutation
Costello syndrome is unlikely, but consider other genetic disorders if symptoms persist. Further testing may be needed.
Variant of uncertain significance (VUS)
A genetic variant was found, but its clinical significance is unknown. Repeat testing or family studies may be recommended.
Consult a doctor or genetic counselor if the test is positive, if symptoms of Costello syndrome are present, or if there is a family history of the disorder. Also, seek advice for management of associated health issues.
Limitations
- ⚠May not detect all types of HRAS mutations, such as large deletions or duplications
- ⚠Variants of uncertain significance (VUS) may be identified, requiring further evaluation
- ⚠Does not rule out other genetic disorders with overlapping symptoms
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Psychological impact of genetic results may require counseling
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
- ●Recent blood transfusions may affect results
Frequently Asked Questions
What is Costello syndrome?
How is Costello syndrome diagnosed?
What does the HRAS Gene NGS Test involve?
Who should consider this test?
What is the cost of the test?
How long does it take to get results?
Is home sample collection available?
What if the test result is positive?
Can the test rule out Costello syndrome?
Are there any risks associated with the test?
What is the significance of raw data and VCF files?
How can I prepare for the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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