Immunoglobulin IgG CSF Test
Short Name: IgG CSF Test
Also known as: CSF IgG Test, Lumbar Puncture IgG Test, Cerebrospinal Fluid Immunoglobulin G Test
Immunoglobulin IgG CSF Test test available at DNA Labs India for ₹1,615. Uses Nephelometry on Cerebrospinal Fluid (CSF) samples. Results in Next day after sample collection, provided sample is received by 4 pm Mon-Sat.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
To measure IgG levels in cerebrospinal fluid for diagnosing neurological disorders, including multiple sclerosis, neurosyphilis, and autoimmune conditions, by comparing CSF and blood IgG concentrations.
- Test Code
- 871
- Price
- ₹1,615
- Sample Type
- Cerebrospinal Fluid (CSF)
- Result Time
- Next day after sample collection, provided sample is received by 4 pm Mon-Sat.
- Fasting Required
- No
- Method
- Nephelometry
Sample Collection
No special preparation required. Inform your doctor about any medications or health conditions.
Method: Lumbar puncture or spinal tap
Laboratory Analysis
The procedure involves a lumbar puncture, where a needle is inserted into the lower back to collect CSF. Local anesthesia is used to minimize discomfort.
Report Delivery
You may experience mild headache or back pain. Rest and hydration are recommended. Avoid strenuous activities for 24 hours.
Timeline: Next day after sample collection, provided sample is received by 4 pm Mon-Sat.
Patient Instructions
About This Test
Who Should Get This Test
To measure IgG levels in cerebrospinal fluid for diagnosing neurological disorders, including multiple sclerosis, neurosyphilis, and autoimmune conditions, by comparing CSF and blood IgG concentrations.
How to Prepare
- Sample must be collected in a sterile screw-capped container
- Ship refrigerated or frozen to maintain stability
- Minimum volume 1 mL, ideal 2 mL
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"This test is crucial for evaluating inflammatory and autoimmune conditions affecting the central nervous system, helping to guide treatment decisions in disorders like multiple sclerosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Contaminated or hemolyzed sample
- Improper labeling or storage
Understanding Your Results
Elevated CSF IgG with high index
May indicate multiple sclerosis, neurosyphilis, or autoimmune encephalitis
Normal CSF IgG
Less likely for inflammatory neurological disorders
Elevated CSF IgG with normal index
Could be due to systemic inflammation or blood-brain barrier disruption
If you experience persistent neurological symptoms such as balance issues, vision changes, or cognitive decline, or if test results are abnormal, consult a neurologist for further evaluation.
Limitations
- ⚠Not diagnostic alone; requires clinical correlation
- ⚠Results may be affected by other inflammatory conditions
- ⚠Limited to central nervous system evaluation
Risks & Considerations
- ●Mild headache or backache
- ●Rare risk of infection or bleeding
- ●Possible nerve irritation
Interfering Factors
- ●Hemolysis in the CSF sample
- ●Recent blood transfusion or immunotherapy
- ●Contamination during collection
Compare With Similar Tests
| Test | Immunoglobulin IgG CSF Test | Oligoclonal Bands Test | CSF Protein Test | MRI Brain | Evoked Potentials Test |
|---|---|---|---|---|---|
| Comparison | Immunoglobulin IgG CSF Test | Detects specific antibody patterns in CSF for multiple sclerosis diagnosis | Measures total protein levels, which may be elevated in inflammation | Imaging test to visualize structural changes in the brain | Assesses nerve pathway function, often used alongside CSF tests |
Frequently Asked Questions
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