Immunohistochemistry CD21 Test
Short Name: IHC CD21 Test
Also known as: IHC CD21, CD21 Immunohistochemistry, Complement Receptor 2 Test
Immunohistochemistry CD21 Test test available at DNA Labs India for ₹3,000. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block samples. Results in Reports are typically available within 5 to 7 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To diagnose immune system disorders, confirm lymphoid follicles in tissue, and support the diagnosis of cancers like follicular dendritic cell sarcoma through detection of CD21 protein expression.
- Test Code
- 918
- Price
- ₹3,000
- Sample Type
- Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded block
- Result Time
- Reports are typically available within 5 to 7 days after sample collection.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide a copy of the histopathology report, site of biopsy, and clinical history to the laboratory.
Method: Biopsy collection
Laboratory Analysis
Standard biopsy procedure is performed by a healthcare professional, with tissue samples collected and preserved appropriately.
Report Delivery
Sample is fixed in 10% Formal-saline or embedded in paraffin for analysis; instructions for storage and transportation are followed.
Timeline: Reports are typically available within 5 to 7 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
To diagnose immune system disorders, confirm lymphoid follicles in tissue, and support the diagnosis of cancers like follicular dendritic cell sarcoma through detection of CD21 protein expression.
How to Prepare
- Ensure biopsy tissue is fresh and properly labeled
- Use 10% Formal-saline or formalin for fixation
- Ship at room temperature in a secure container
- Include histopathology report, biopsy site, and clinical history
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for evaluating immune system disorders and diagnosing conditions like follicular dendritic cell sarcoma, aiding in accurate cancer staging and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate sample size or quality
- Improper fixation or container
- Missing required clinical information
Understanding Your Results
Positive CD21 staining
Confirms presence of follicular dendritic cells or lymphoid follicles, supporting diagnosis of conditions like follicular dendritic cell sarcoma or immune disorders.
Action: Consult with an oncologist or immunologist for further evaluation and treatment planning.
Negative CD21 staining
Suggests absence of CD21 expression, which may indicate other pathological processes; correlation with clinical context is essential.
Action: Review with a specialist to determine alternative diagnoses or additional tests.
If you experience symptoms such as recurring infections, chronic fatigue, swollen lymph nodes, or unexplained weight loss, consult a healthcare provider promptly for evaluation and possible CD21 testing.
Limitations
- ⚠Cannot be used as a standalone diagnostic tool; must be correlated with clinical history and other tests
- ⚠Results may vary based on tissue type and biopsy site
- ⚠Limited to immunohistochemical detection; not quantitative for CD21 levels in blood
Risks & Considerations
- ●Biopsy-related risks such as infection, bleeding, or pain at the site
- ●Rare allergic reactions to fixatives
- ●Emotional distress from awaiting results
Interfering Factors
- ●Improper sample fixation or preservation
- ●Inadequate tissue quality or quantity
- ●Contamination during collection or processing
Compare With Similar Tests
| Test | Immunohistochemistry CD21 Test | Immunohistochemistry CD30 | Flow Cytometry | Bone Marrow Biopsy | Serum Immunoglobulins Test |
|---|---|---|---|---|---|
| Comparison | Immunohistochemistry CD21 Test |
Frequently Asked Questions
What is the Immunohistochemistry CD21 test?
Why is the CD21 test ordered?
What sample is required for this test?
Is fasting needed before the CD21 test?
How much does the CD21 test cost in India?
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