Immunohistochemistry DNAJB9 Test
Short Name: IHC DNAJB9 Test
Also known as: DNAJB9 Immunohistochemistry, IHC for DNAJB9, DNAJB9 Protein Staining
Immunohistochemistry DNAJB9 Test test available at DNA Labs India for ₹2,106. Uses Immunohistochemistry on Tissue sample in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block samples. Results in Sample processing: Daily by 6 pm; Report delivery: 5 days for block, 5 days for tissue biopsy, 7 days for large complex tissues.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of the Immunohistochemistry DNAJB9 test is to identify DNAJB9 protein expression in tissue samples, primarily for diagnosing Fibrillary glomerulonephritis (FGN) and supporting research in cancer detection. It helps nephrologists differentiate FGN from other glomerular diseases, guiding treatment decisions and patient prognosis.
- Test Code
- 992
- Price
- ₹2,106
- Sample Type
- Tissue sample in 10% Formal-saline or Formalin fixed paraffin embedded (FFPE) block
- Result Time
- Sample processing: Daily by 6 pm; Report delivery: 5 days for block, 5 days for tissue biopsy, 7 days for large complex tissues.
- Fasting Required
- No
- Method
- Immunohistochemistry
Sample Collection
Provide complete clinical history and histopathology reports. Ensure biopsy site is prepared as per medical guidelines.
Method: Biopsy procedure
Laboratory Analysis
Tissue biopsy is performed by a healthcare professional under sterile conditions. Sample is placed in formal-saline or fixed as FFPE block.
Report Delivery
Sample is labeled correctly and shipped at room temperature to the laboratory. Avoid delays to prevent degradation.
Timeline: Sample processing: Daily by 6 pm; Report delivery: 5 days for block, 5 days for tissue biopsy, 7 days for large complex tissues.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Immunohistochemistry DNAJB9 test is to identify DNAJB9 protein expression in tissue samples, primarily for diagnosing Fibrillary glomerulonephritis (FGN) and supporting research in cancer detection. It helps nephrologists differentiate FGN from other glomerular diseases, guiding treatment decisions and patient prognosis.
How to Prepare
- Collect tissue biopsy from the affected area, typically kidney for FGN diagnosis
- Place sample in 10% formal-saline or prepare as FFPE block
- Ship at room temperature with proper packaging
- Include a copy of histopathology report, biopsy site details, and clinical history
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The DNAJB9 test is crucial for accurately diagnosing Fibrillary glomerulonephritis, a rare kidney disease with limited treatment options. Early detection through IHC can guide management and improve patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient or degraded tissue sample
- Missing clinical information or histopathology report
- Incorrect sample container or fixation method
- Sample received after stability period
Understanding Your Results
Negative
No DNAJB9 expression detected, making FGN less likely but not ruling out other kidney diseases.
Weak Positive
Low DNAJB9 expression; may require correlation with clinical findings for diagnosis.
Moderate Positive
Moderate DNAJB9 expression; suggestive of FGN or other conditions with fibrillar deposits.
Strong Positive
High DNAJB9 expression; strongly indicative of Fibrillary glomerulonephritis (FGN).
Consult a nephrologist if test results are positive, especially with symptoms like proteinuria, hematuria, or declining kidney function. Also, seek advice for further management if negative but clinical suspicion remains.
Limitations
- ⚠This test is qualitative and may not quantify protein levels precisely
- ⚠Results should be correlated with clinical history and other diagnostic tests
- ⚠False positives or negatives can occur due to sample quality issues
- ⚠Limited availability in remote areas without advanced laboratory facilities
Risks & Considerations
- ●Biopsy-related risks: bleeding, infection, or pain at the site
- ●Allergic reactions to anesthesia or staining reagents
- ●Inconclusive results requiring repeat testing
Interfering Factors
- ●Inadequate tissue fixation or preservation
- ●Use of incorrect antibodies or staining protocols
- ●Contamination or degradation of tissue sample
- ●Technical errors during immunohistochemical processing
Compare With Similar Tests
| Test | Immunohistochemistry DNAJB9 Test | Renal Biopsy | Serum Creatinine Test | Immunofluorescence Microscopy | Urinalysis | Other IHC Panels |
|---|---|---|---|---|---|---|
| Comparison | Immunohistochemistry DNAJB9 Test | DNAJB9 IHC is a specific staining technique applied to renal biopsy samples for FGN diagnosis, while renal biopsy involves overall tissue examination. | Serum creatinine assesses kidney function, whereas DNAJB9 IHC identifies molecular markers in tissue for precise disease diagnosis. | Both are histopathological techniques, but IHC for DNAJB9 uses antibody-based staining for specific protein detection, unlike general immunofluorescence. | Urinalysis evaluates urine for abnormalities, while DNAJB9 IHC provides direct tissue-level evidence of kidney disease. | DNAJB9 IHC is specific for FGN, whereas other IHC panels may target different proteins for various cancer or disease diagnoses. |
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