Insulin Antibodies Highly Sensitive Test
Short Name: IAHS Test
Also known as: IAHS Test, Insulin Autoantibody Test, IAA Test, Insulin Antibody Radioimmunoassay
Insulin Antibodies Highly Sensitive Test test available at DNA Labs India for ₹15,000. Uses Radioimmunoassay (RIA) on Serum samples. Results in Sample must be submitted by the 7th of the month. Reports are available within 2-3 weeks after the reference laboratory receives the sample. Reports are delivered via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The Insulin Antibodies Highly Sensitive Test is used to detect the presence of insulin autoantibodies in the blood. This test serves several clinical purposes: it helps assess lower titers of autoantibody in patients with diabetes, detects insulin autoantibody in patients who are prediabetic, and identifies autoantibody in patients with other autoimmune disorders. When combined with GAD-65 and ICA-512 antibody measurements, it provides a highly sensitive means to assess risk and predict the onset of Type 1 diabetes. The test is also useful in evaluating insulin autoimmune syndrome (Hirata disease) and differentiating between Type 1 and Type 2 diabetes in ambiguous clinical presentations.
- Test Code
- 1115
- CPT Code
- 86341
- ICD Code
- E10.9
- Price
- ₹15,000
- Sample Type
- Serum
- Result Time
- Sample must be submitted by the 7th of the month. Reports are available within 2-3 weeks after the reference laboratory receives the sample. Reports are delivered via online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Radioimmunoassay (RIA)
Sample Collection
A duly filled Test Send Out Consent Form (Form 35) is mandatory prior to sample collection. No specific fasting is required, but follow any instructions provided by your referring physician. Inform your doctor about any insulin therapy, immunosuppressive medications, or recent vaccinations that may affect results.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw approximately 2 mL of blood from a vein in your arm using standard venipuncture technique. The blood will be collected into a Red Top (No Additive) tube. Do not use SST gel barrier tubes for this test. The procedure typically takes 5-10 minutes.
Report Delivery
Serum must be separated from the clot within 1 hour of collection. The separated serum should be shipped refrigerated (2-8°C) or frozen. Apply gentle pressure to the puncture site with a cotton ball for 3-5 minutes to stop bleeding. You may resume normal activities immediately after sample collection.
Timeline: Sample must be submitted by the 7th of the month. Reports are available within 2-3 weeks after the reference laboratory receives the sample. Reports are delivered via online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The Insulin Antibodies Highly Sensitive Test is used to detect the presence of insulin autoantibodies in the blood. This test serves several clinical purposes: it helps assess lower titers of autoantibody in patients with diabetes, detects insulin autoantibody in patients who are prediabetic, and identifies autoantibody in patients with other autoimmune disorders. When combined with GAD-65 and ICA-512 antibody measurements, it provides a highly sensitive means to assess risk and predict the onset of Type 1 diabetes. The test is also useful in evaluating insulin autoimmune syndrome (Hirata disease) and differentiating between Type 1 and Type 2 diabetes in ambiguous clinical presentations.
How to Prepare
- Duly filled Test Send Out Consent Form (Form 35) is mandatory
- Collect 2 mL (1 mL minimum) of blood in a Red Top (No Additive) tube
- Do NOT use SST gel barrier tubes
- Separate serum from clot within 1 hour of collection
- Ship sample refrigerated (2-8°C) or frozen
- Sample must reach the reference laboratory by the 7th of the month
- Ensure proper labeling with patient name, date, and sample ID
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"The Insulin Antibodies Highly Sensitive test is a valuable tool in the early risk stratification of Type 1 diabetes, particularly when interpreted alongside GAD-65 and ICA-512 antibody panels. Detection of insulin autoantibodies in presymptomatic individuals allows for closer metabolic monitoring and timely intervention. I recommend this test for patients with a family history of autoimmune diabetes, those with unexplained glycemic variability, or individuals undergoing insulin therapy where immune-mediated insulin resistance is suspected. Early identification of insulin autoantibodies can significantly alter clinical management and improve long-term patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected in SST gel barrier tubes
- Serum not separated within 1 hour of collection
- Hemolyzed or grossly lipemic samples
- Missing or incomplete Test Send Out Consent Form (Form 35)
- Insufficient sample volume (less than 1 mL serum)
- Sample received at room temperature beyond 8 hours of collection
Understanding Your Results
Negative — No significant insulin autoantibodies detected. Low risk of autoimmune diabetes, though clinical correlation is advised.
Range: Less than 0.4 U/mL
Equivocal — Borderline levels detected. Repeat testing and correlation with other autoimmune markers (GAD-65, ICA-512) is recommended.
Range: 0.4 - 1.0 U/mL
Positive — Significant insulin autoantibodies detected. Suggests autoimmune activity against pancreatic beta cells, consistent with Type 1 diabetes risk or insulin autoimmune syndrome. Further clinical evaluation is necessary.
Range: Greater than 1.0 U/mL
Consult your endocrinologist or diabetologist if your IAHS test result is positive or equivocal, if you are experiencing symptoms such as frequent urination, excessive thirst, unexplained weight loss, fatigue, or blurred vision, or if you have a family history of Type 1 diabetes or other autoimmune conditions. Early consultation allows for timely monitoring and intervention.
Limitations
- ⚠This is a send-out test; results require 2-3 weeks after sample receipt at the reference laboratory
- ⚠Insulin antibody levels alone are not diagnostic and must be interpreted alongside clinical findings and other autoimmune markers
- ⚠A negative result does not completely exclude autoimmune diabetes
- ⚠The test may not distinguish between autoantibodies and antibodies formed due to exogenous insulin therapy
- ⚠Results may vary between laboratories due to differences in RIA assay kits and methodologies
Risks & Considerations
- ●Minor bruising or swelling at the blood draw site
- ●Slight discomfort or pain during needle insertion
- ●Very rare risk of fainting or dizziness during venipuncture
- ●Minimal risk of infection at the puncture site
Interfering Factors
- ●Recent insulin therapy may affect results due to exogenous insulin antibodies
- ●Use of SST gel barrier tubes can interfere with sample integrity
- ●Sample not separated within 1 hour of collection may yield inaccurate results
- ●Hemolyzed or lipemic samples may affect assay performance
- ●Immunosuppressive medications may lower antibody titers
Compare With Similar Tests
| Test | Insulin Antibodies Highly Sensitive Test | GAD-65 Antibodies Test | ICA-512 (IA-2) Antibodies Test | Fasting Insulin Test |
|---|---|---|---|---|
| Comparison | Insulin Antibodies Highly Sensitive Test |
Frequently Asked Questions
What is the Insulin Antibodies Highly Sensitive Test?
Why is the IAHS test important?
Who should get the Insulin Antibodies Highly Sensitive Test?
Is fasting required for the IAHS test?
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What does a positive IAHS test result mean?
What is the cost of the Insulin Antibodies Highly Sensitive Test in India?
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Can the IAHS test diagnose Type 1 diabetes on its own?
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Reference Laboratory Services
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