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DNA Labs India

Kardiogen Polygenic Risk Score Test

DNA Labs India | ISO 9001:2015 Certified

Kardiogen Polygenic Risk Score Test

Short Name: Kardiogen PRS

Also known as: CAD-PRS, Kardiogen Risk Score, Heart Polygenic Risk Test

Kardiogen Polygenic Risk Score Test test available at DNA Labs India for ₹20,000. Uses Array-based Whole Genome Genotyping, Custom Bioinformatics Pipeline on EDTA Blood samples. Results in Results are typically available within 3-4 weeks. You will receive a detailed report with your Kardiogen Risk Score, decile placement, and interpretation.. Free home collection in 300+ cities across India.

Polygenic Risk ScoreAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The primary purpose of the Kardiogen Polygenic Risk Score Test is to identify individuals at elevated genetic risk for Coronary Artery Disease (CAD) before clinical symptoms appear. This allows for early intervention and personalized prevention, potentially reducing the incidence of heart attacks and other cardiovascular events. The test is designed for healthy adults who want to understand their genetic predisposition and take proactive steps to mitigate risk.

Test Code
6456
CPT Code
81425
ICD Code
Z13.6
Price
₹20,000
Sample Type
EDTA Blood
Result Time
Results are typically available within 3-4 weeks. You will receive a detailed report with your Kardiogen Risk Score, decile placement, and interpretation.
Fasting Required
No
Method
Array-based Whole Genome Genotyping, Custom Bioinformatics Pipeline
Step 1

Sample Collection

No special preparation is required. Maintain normal hydration and avoid strenuous exercise immediately before sample collection.

Method: Venipuncture

Step 2

Laboratory Analysis

A standard blood draw will be performed by a trained phlebotomist. The procedure takes less than 5 minutes.

Step 3

Report Delivery

You may resume normal activities immediately. A small bruise may appear at the puncture site, which is normal.

Timeline: Results are typically available within 3-4 weeks. You will receive a detailed report with your Kardiogen Risk Score, decile placement, and interpretation.

Patient Instructions

1
Before the Test:No special preparation is required. You can eat and drink normally.
2
During the Test:A blood sample is drawn from a vein in your arm. The process is quick and routine.
3
After the Test:You can resume all normal activities immediately. Your sample will be sent to our ISO-certified laboratory for analysis.

About This Test

Who Should Get This Test

The primary purpose of the Kardiogen Polygenic Risk Score Test is to identify individuals at elevated genetic risk for Coronary Artery Disease (CAD) before clinical symptoms appear. This allows for early intervention and personalized prevention, potentially reducing the incidence of heart attacks and other cardiovascular events. The test is designed for healthy adults who want to understand their genetic predisposition and take proactive steps to mitigate risk.

How to Prepare

  • Ensure the EDTA vacutainer is properly labeled with your name and date of birth
  • Sample must be transported to the laboratory within 24 hours of collection
  • Keep the sample at room temperature (15-25°C) during transport

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test provides a critical layer of risk assessment beyond traditional factors. Early identification of high polygenic risk allows for aggressive preventive therapy, potentially reducing the burden of CAD in our population."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeEDTA Blood
Sample Volume2 mL
ContainerEDTA Vacutainer
Collection MethodVenipuncture

Sample Stability

Whole blood in EDTA: 24 hours at room temperature
Whole blood in EDTA: 7 days at 2-8°C
Extracted DNA: stable for years at -20°C
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Incorrect anticoagulant tube
  • Sample received after 7 days of collection
  • Improper labeling

Understanding Your Results

Your Kardiogen Risk Score (KRS) is reported as an odds ratio compared to the general South Asian population. A score of 1.00 indicates average risk, while higher scores indicate increased genetic susceptibility.
📊

Your genetic risk for CAD is similar to the general population. Continue standard preventive measures.

Recommendation: Maintain a heart-healthy lifestyle and regular checkups.

📊

Your genetic risk is moderately elevated. Consider enhanced screening and lifestyle modifications.

Recommendation: Discuss with your cardiologist about lipid panel and blood pressure monitoring.

📊

Your genetic risk is significantly elevated (up to 3.08 times the population average). Aggressive prevention is recommended.

Recommendation: Work with a cardiologist to consider statin therapy and intensive lifestyle changes.

⚠️ When to Consult a Doctor:

If your Kardiogen Risk Score falls in the Moderate or High risk category, it is strongly recommended to consult with a cardiologist for a comprehensive risk assessment and personalized prevention plan.

Limitations

  • ⚠This is a risk assessment, not a diagnostic test for CAD
  • ⚠Does not detect rare monogenic forms of heart disease
  • ⚠Risk estimates are based on population averages; individual outcomes may vary
  • ⚠Not intended for individuals with known CAD or acute coronary syndrome

Risks & Considerations

  • ●Minimal risk of bruising or infection at the puncture site
  • ●Psychological impact of learning about genetic risk
  • ●Potential for incidental findings (not applicable for this test)

Interfering Factors

  • ●Recent blood transfusion (may dilute DNA)
  • ●Active hematological malignancy (may alter DNA composition)
  • ●Insufficient sample volume or improper storage

Compare With Similar Tests

TestKardiogen Polygenic Risk Score TestLipid ProfileCAC ScoreFramingham Risk Score
ComparisonKardiogen Polygenic Risk Score Test

Frequently Asked Questions

What exactly is a Polygenic Risk Score (PRS)?
A Polygenic Risk Score calculates the combined, overlapping effects of a massive network of minor genetic variations across your genome. Unlike single-gene tests for monogenic conditions, PRS evaluates common, highly integrated conditions where thousands of tiny genetic switches shape your overall physiological susceptibility.
Does this test mean I am definitively going to get heart disease?
Absolutely not. This is a predictive screening test, not a diagnostic verdict. Scoring in 'Average' or 'High' risk highlights your baseline genetic probability. Diet, weight, stress, blood pressure, and fitness play massive roles in whether those genes manifest as illness.
How do I interpret my explicit Odds-Ratio?
Your odds ratio acts as a mathematical multiplier against the population baseline. An 'Average' bracket yields an odds ratio ? 1.00 (typical risk). A 'High' risk bracket yields an odds ratio of 3.08, meaning roughly three times more likely to develop CAD than the population benchmark.
Can I share these results with my physician?
Yes, and you are strongly urged to do so. While your genetic score cannot be altered, clinical risk factors (LDL cholesterol, blood pressure) are highly malleable via medical interventions, statins, and lifestyle modifications curated by a cardiologist.
How accurate is the modeling for individuals of Asian descent?
This is a standout attribute. The Kardiogen algorithm is thoroughly optimized and validated using DNA Labs India's South Asian study cohort, ensuring predictive metrics are highly relevant to South Asian genetic architectures.
What is the cost of the Kardiogen test?
The all-inclusive price is ?20,000, which covers the genetic analysis, comprehensive report, and pre- and post-test genetic counseling.
Is home sample collection available?
Yes, we offer free home sample collection across 300+ cities in India. A trained phlebotomist will visit your location at your convenience.
How long does it take to get results?
The turnaround time is 3-4 weeks from the date of sample receipt at the laboratory.
What type of sample is required?
A simple EDTA blood sample is required. No fasting is needed.
Is this test suitable for people with existing heart disease?
No, this test is designed for healthy individuals without known CAD. If you have existing heart disease, please consult your cardiologist for appropriate management.
Will my insurance cover this test?
Most insurance plans do not cover preventive genetic tests. However, you may check with your provider for possible reimbursement under preventive care benefits.
What is the scientific basis of this test?
The test leverages a multi-ethnic risk model developed by Harvard Medical School and published in Nature Medicine, and is validated on a South Asian cohort of 2,963 individuals for local accuracy.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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