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KARS1 Gene Deafness, autosomal recessive type 89 NGS Genetic Test

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KARS1 Gene Deafness, autosomal recessive type 89 NGS Genetic Test

Short Name: KARS1 Gene Deafness Test

Also known as: KARS1-related deafness, Autosomal recessive deafness 89

KARS1 Gene Deafness, autosomal recessive type 89 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the KARS1 gene that cause autosomal recessive deafness type 89, enabling accurate diagnosis, informed treatment decisions, genetic counseling, and family risk assessment.

Test Code
4753
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

Consult with a genetic counselor to discuss family history and test implications. No fasting required.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm or a saliva sample collected using a kit. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history, risks, and benefits of testing.
2
During the Test:Sample collection via blood draw or saliva, followed by DNA extraction and NGS analysis in the laboratory.
3
After the Test:Review of results by a medical geneticist and genetic counselor, with report delivery in 3-4 weeks.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the KARS1 gene that cause autosomal recessive deafness type 89, enabling accurate diagnosis, informed treatment decisions, genetic counseling, and family risk assessment.

How to Prepare

  • Ensure proper identification of the patient
  • Use sterile collection tubes
  • Label samples accurately
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for KARS1 gene mutations is crucial for early diagnosis and management of autosomal recessive deafness, aiding in family planning and treatment decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva collection

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the KARS1 gene. Positive results confirm genetic deafness, while negative results may require further testing.
Positive: Pathogenic variant detected, confirming KARS1 gene deafness
Negative: No pathogenic variants found, but clinical correlation needed
Variant of uncertain significance: Requires further evaluation and genetic counseling
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of hearing loss, have a family history of deafness, or receive a positive genetic test result for management and counseling.

Limitations

  • ⚠May not detect all genetic variants or non-coding mutations
  • ⚠Results require interpretation by a genetic counselor
  • ⚠Does not rule out other causes of deafness

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Insufficient sample volume
  • ●Recent blood transfusion may affect results

Compare With Similar Tests

TestKARS1 Gene Deafness, autosomal recessive type 89 NGS Genetic TestGJB2 Gene Deafness TestSLC26A4 Gene Deafness TestTMC1 Gene Deafness TestOTOF Gene Deafness TestComprehensive Deafness Panel
ComparisonKARS1 Gene Deafness, autosomal recessive type 89 NGS Genetic Test

Frequently Asked Questions

What is KARS1 gene deafness?
KARS1 gene deafness is a rare autosomal recessive condition caused by mutations in the KARS1 gene, leading to hearing loss due to impaired protein synthesis essential for auditory function.
How is KARS1 gene deafness inherited?
It is inherited in an autosomal recessive pattern, meaning both parents must carry a mutated gene for a child to be affected.
What are the symptoms of KARS1 gene deafness?
Symptoms include hearing loss (mild to profound), tinnitus, difficulty understanding speech in noise, trouble hearing high-pitched sounds, and delayed language development in children.
How is KARS1 gene deafness diagnosed?
Diagnosis involves clinical evaluation by an audiologist and genetic testing using NGS to detect mutations in the KARS1 gene.
What is the cost of the KARS1 gene deafness test in India?
The test costs INR 20000 at DNA Labs India, with free home sample collection available across India.
Is genetic testing for KARS1 gene deafness covered by insurance?
Genetic testing is not always covered by insurance; it is advisable to check with your provider. DNA Labs India offers financial assistance options.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What sample is required for the test?
The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across numerous cities in India.
What if the test result is positive?
A positive result confirms KARS1 gene deafness; genetic counseling is recommended to discuss management, family planning, and support options.
Can KARS1 gene deafness be prevented?
As a genetic condition, it cannot be prevented, but early diagnosis through testing can aid in management and informed decision-making.
Where can I get the KARS1 gene deafness test done?
You can book the test at DNA Labs India, which provides services across India with home collection and walk-in options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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