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DNA Labs India

KISS1 Gene Hypogonadotropic hypogonadism NGS Genetic Test

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KISS1 Gene Hypogonadotropic hypogonadism NGS Genetic Test

Short Name: KISS1 HH NGS Test

Also known as: KISS1 gene mutation-related hypogonadism, KISS1-related hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism type 6

KISS1 Gene Hypogonadotropic hypogonadism NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose KISS1 gene mutations causing hypogonadotropic hypogonadism, enabling early intervention, family planning, and genetic counseling.

Test Code
5533
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Inform the lab about any medications or medical conditions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:No specific preparation required. Inform the lab about any medications or medical conditions.
2
During the Test:A blood sample will be drawn from a vein in your arm by a trained phlebotomist.
3
After the Test:Apply pressure to the puncture site to stop bleeding. Resume normal activities immediately.

About This Test

Who Should Get This Test

To diagnose KISS1 gene mutations causing hypogonadotropic hypogonadism, enabling early intervention, family planning, and genetic counseling.

How to Prepare

  • No fasting required for this test
  • Wear loose clothing for easy access
  • Bring identification and prescription if available

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is crucial for diagnosing genetic causes of hypogonadotropic hypogonadism, enabling targeted treatment and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml of blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood samples stable for 48 hours at room temperature
FTA cards stable for years when stored properly
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Incorrect labeling or documentation

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the KISS1 gene.
Normal: No pathogenic variants detected, suggesting no genetic cause from KISS1 gene
Abnormal: Pathogenic variant detected, indicating a genetic basis for hypogonadotropic hypogonadism
⚠️ When to Consult a Doctor:

If symptoms of hypogonadotropic hypogonadism are present, such as delayed puberty or infertility, or if there is a family history of the disorder.

Limitations

  • ⚠May not detect all types of genetic mutations
  • ⚠Results require interpretation by a genetic counselor
  • ⚠Not a standalone diagnostic tool; clinical correlation is needed

Risks & Considerations

  • ●Minor bruising at the puncture site
  • ●Rare risk of infection

Interfering Factors

  • ●Poor sample quality
  • ●Contamination
  • ●Technical errors during sequencing

Frequently Asked Questions

What is the KISS1 Gene Hypogonadotropic Hypogonadism NGS Genetic Test?
It is a genetic test that uses Next Generation Sequencing to detect mutations in the KISS1 gene, which can cause hypogonadotropic hypogonadism, a disorder affecting puberty and reproductive function.
How is the test performed?
A blood sample is collected and analyzed using NGS technology to sequence the KISS1 gene for any mutations.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with home sample collection available.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What are the symptoms of KISS1 gene-related hypogonadotropic hypogonadism?
Symptoms include delayed puberty, infertility, low sex hormone levels, decreased sex drive, erectile dysfunction, and osteoporosis.
Who should consider this test?
Individuals with symptoms of hypogonadotropic hypogonadism, a family history of the disorder, or those seeking genetic counseling for reproductive issues.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the KISS1 gene, suggesting a genetic cause for hypogonadotropic hypogonadism.
Is genetic counseling provided?
Yes, genetic counseling is recommended before and after testing to understand results and implications.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw, but serious complications are rare.
How accurate is the NGS technology?
NGS is highly accurate for detecting genetic mutations, but results should be interpreted in clinical context.
Can this test be used for family planning?
Yes, it helps identify genetic risks, enabling informed family planning decisions and carrier testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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