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KISS1R Gene Hypogonadotropic hypogonadism NGS Genetic Test

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KISS1R Gene Hypogonadotropic hypogonadism NGS Genetic Test

Short Name: KISS1R Gene HH NGS Test

Also known as: KISS1R Gene Test, HH Genetic Test, Hypogonadotropic Hypogonadism NGS Test, KISS1R Mutation Analysis

KISS1R Gene Hypogonadotropic hypogonadism NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the KISS1R gene that cause hypogonadotropic hypogonadism, aiding in diagnosis, treatment planning, and genetic counseling.

Test Code
5435
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with hypogonadotropic hypogonadism.

Method: Venipuncture or FTA card spotting

Step 2

Laboratory Analysis

Standard blood draw or FTA card collection procedure performed by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site; monitor for any adverse reactions.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor, provide clinical history, and ensure no recent blood transfusions.
2
During the Test:Blood sample collection via venipuncture or FTA card; minimal discomfort.
3
After the Test:Resume normal activities; monitor puncture site for bleeding or bruising.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the KISS1R gene that cause hypogonadotropic hypogonadism, aiding in diagnosis, treatment planning, and genetic counseling.

How to Prepare

  • Provide detailed clinical history
  • Attend genetic counseling session
  • Ensure sample is collected in appropriate container
  • Label sample correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for identifying KISS1R gene mutations in patients with hypogonadotropic hypogonadism, enabling targeted treatment and genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood or equivalent DNA
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card spotting

Sample Stability

Room TemperatureUp to 48 hours for blood; FTA cards stable for years
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the KISS1R gene. Positive results confirm a genetic cause for hypogonadotropic hypogonadism, while negative results may require further genetic testing.
📊

No pathogenic variants detected

Normal; no KISS1R gene mutations identified. Consider other genetic or non-genetic causes.

📊

Pathogenic variants detected

Abnormal; confirms KISS1R gene-related hypogonadotropic hypogonadism. Genetic counseling and targeted treatment recommended.

⚠️ When to Consult a Doctor:

If experiencing symptoms of hypogonadotropic hypogonadism, such as delayed puberty or infertility, or if there is a family history of the condition.

Limitations

  • ⚠Test may not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Limited to KISS1R gene mutations only

Risks & Considerations

  • ●Minor bruising or pain at puncture site
  • ●Rare risk of infection
  • ●Emotional impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Recent blood transfusions

Frequently Asked Questions

What is the KISS1R Gene Hypogonadotropic Hypogonadism NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to identify mutations in the KISS1R gene, which can cause hypogonadotropic hypogonadism, a condition affecting reproductive hormone production.
Who should consider getting this test?
Individuals with symptoms of hypogonadotropic hypogonadism, such as delayed puberty, infertility, or sexual dysfunction, and those with a family history of the condition.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to detect mutations in the KISS1R gene.
What is the cost of the test?
The test costs INR 20000 in India, with home sample collection available at no extra charge.
Is the test covered by health insurance?
It is typically covered by health insurance, but coverage may vary. Check with your insurance provider for details.
How long does it take to get results?
Results are usually available within 3 to 4 weeks after sample collection.
What are the symptoms of hypogonadotropic hypogonadism?
Symptoms include delayed puberty, decreased muscle mass, reduced body hair, small testes in males, and lack of breast development or irregular periods in females.
How is hypogonadotropic hypogonadism diagnosed?
Diagnosis involves physical exams, blood tests for hormone levels, imaging studies, and genetic testing like this NGS test.
What is the role of the KISS1R gene?
The KISS1R gene produces the Kisspeptin receptor, which regulates GnRH production. Mutations can disrupt this process, leading to hypogonadotropic hypogonadism.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What should I do before getting tested?
Provide clinical history, attend a genetic counseling session, and ensure no recent blood transfusions that might affect results.
How accurate is the test?
NGS technology provides high accuracy for detecting genetic mutations, but results should be interpreted in conjunction with clinical findings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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