KRAS Gene Noonan syndrome type 3 NGS Genetic Test
Short Name: KRAS Noonan NGS
Also known as: KRAS gene mutation test, Noonan syndrome type 3 genetic test, KRAS NGS panel
KRAS Gene Noonan syndrome type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm or rule out a diagnosis of Noonan syndrome type 3 by identifying pathogenic mutations in the KRAS gene. It is indicated for individuals with clinical features suggestive of Noonan syndrome, particularly when other RASopathies are considered. The test also aids in genetic counseling, reproductive planning, and early intervention for associated complications such as cardiac defects, growth issues, and cancer predisposition.
- Test Code
- 5869
- CPT Code
- 81408
- ICD Code
- Q87.1
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are delivered within 3 to 4 weeks from sample receipt.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting required. A genetic counseling session is recommended to discuss the test implications and family history. Please bring any previous medical records, echocardiogram reports, or genetic test results.
Method: Venipuncture or FTA card blood spot
Laboratory Analysis
A blood sample will be drawn by a trained phlebotomist. For FTA card, a few drops of blood will be placed on the card. The procedure is quick and minimally invasive.
Report Delivery
No special precautions. You may resume normal activities. The sample will be transported to the laboratory for analysis. Results will be available in 3-4 weeks.
Timeline: Reports are delivered within 3 to 4 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm or rule out a diagnosis of Noonan syndrome type 3 by identifying pathogenic mutations in the KRAS gene. It is indicated for individuals with clinical features suggestive of Noonan syndrome, particularly when other RASopathies are considered. The test also aids in genetic counseling, reproductive planning, and early intervention for associated complications such as cardiac defects, growth issues, and cancer predisposition.
How to Prepare
- Ensure the sample is collected in an EDTA tube (for blood) or on an FTA card
- For FTA card, allow the blood spot to air dry completely before sealing
- Label the sample with patient name, date of birth, and collection date
- Transport the sample at ambient temperature; avoid extreme heat or cold
- Do not freeze whole blood samples
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early genetic confirmation of KRAS-related Noonan syndrome enables timely surveillance for cardiac, growth, and cancer risks. This NGS test provides high sensitivity for mosaic and point mutations."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improper labeling or missing patient information
- Sample received after prolonged transit (>72 hours) without proper storage
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of Noonan syndrome type 3. Genetic counseling and family screening recommended.
Likely pathogenic variant detected
Highly suggestive of disease; further evidence may be needed. Clinical correlation essential.
Variant of uncertain significance (VUS)
Cannot confirm or exclude diagnosis. Additional testing of family members may help classify.
No pathogenic variant detected
Does not rule out Noonan syndrome; other genes may be involved. Consider broader RASopathy panel.
Consult a clinical geneticist or pediatrician if you or your child has features of Noonan syndrome, such as short stature, heart defects, or dysmorphic features. Also seek genetic counseling if there is a family history of the condition.
Limitations
- ⚠This test only analyzes the KRAS gene; mutations in other RASopathy genes will not be detected
- ⚠Large deletions/duplications may not be detected by standard NGS
- ⚠Variant of uncertain significance (VUS) may require additional family studies
- ⚠Regulatory regions and deep intronic variants are not covered
- ⚠Test does not assess methylation or imprinting defects
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of receiving a genetic diagnosis
- ●Potential for uncertain results (VUS) requiring further testing
Interfering Factors
- ●Poor DNA quality or quantity from sample
- ●Contamination during sample collection
- ●Presence of maternal cell contamination in prenatal samples
- ●Mosaic mutations may be below detection limit
- ●Recent blood transfusion may dilute patient DNA
Compare With Similar Tests
| Test | KRAS Gene Noonan syndrome type 3 NGS Genetic Test | KRAS Single Gene Sequencing | RASopathy NGS Panel | Chromosomal Microarray |
|---|---|---|---|---|
| Comparison | KRAS Gene Noonan syndrome type 3 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the KRAS Gene Noonan Syndrome Type 3 NGS Genetic Test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get the results?
Will I receive raw data files?
Is home sample collection available?
What does the test detect?
Can this test be done on children?
What is the difference between this test and a RASopathy panel?
Are there any risks associated with the test?
How should I prepare for the genetic counseling session?
What if the result is negative?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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