KRT16 Gene Palmoplantar keratoderma, nonepidermolytic, focal NGS Genetic Test
Short Name: KRT16 PPK NGS Test
Also known as: Focal PPK, KRT16-related keratoderma, Nonepidermolytic focal palmoplantar keratoderma
KRT16 Gene Palmoplantar keratoderma, nonepidermolytic, focal NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm a diagnosis of KRT16 Gene Palmoplantar Keratoderma by identifying mutations in the KRT16 gene, enabling appropriate medical management and genetic counseling.
- Test Code
- 5102
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. Provide clinical history and family pedigree as advised.
Method: Venipuncture or finger-prick
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist using standard venipuncture or finger-prick methods.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless otherwise directed.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm a diagnosis of KRT16 Gene Palmoplantar Keratoderma by identifying mutations in the KRT16 gene, enabling appropriate medical management and genetic counseling.
How to Prepare
- Ensure sample is collected in a sterile environment
- Label the sample correctly with patient details
- Transport the sample to the lab within the specified stability period
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for KRT16 mutations can aid in accurate diagnosis and guide management strategies for palmoplantar keratoderma, especially in families with a history of the condition."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improper labeling or documentation
Understanding Your Results
Positive for pathogenic mutation
Confirms diagnosis of KRT16-related palmoplantar keratoderma. Genetic counseling recommended.
Negative for pathogenic mutation
No mutations detected in the KRT16 gene. Consider other genetic or non-genetic causes.
Variant of uncertain significance
Further testing or family studies may be needed for clarification.
Consult a dermatologist or geneticist if you experience symptoms such as thickened skin on palms and soles, or if you have a family history of the condition, for appropriate testing and management.
Limitations
- ⚠May not detect all possible mutations in the KRT16 gene
- ⚠Results require interpretation by a genetic specialist
- ⚠Test does not assess for other genetic conditions unless specified
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Very low risk of infection or bleeding
- ●Emotional impact of genetic results; counseling is advised
Interfering Factors
- ●Poor sample quality or insufficient DNA
- ●Contamination during sample collection or processing
- ●Recent blood transfusions may affect DNA analysis
Compare With Similar Tests
| Test | KRT16 Gene Palmoplantar keratoderma, nonepidermolytic, focal NGS Genetic Test | KRT17 Gene Pachyonychia Congenita NGS Test | LORICRIN Gene Vohwinkel Syndrome NGS Test | GJB2 Gene Hearing Loss NGS Test | COL7A1 Gene Epidermolysis Bullosa NGS Test |
|---|---|---|---|---|---|
| Comparison | KRT16 Gene Palmoplantar keratoderma, nonepidermolytic, focal NGS Genetic Test |
Frequently Asked Questions
What is KRT16 Gene Palmoplantar Keratoderma?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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