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DNA Labs India

KRT6B Gene Pachyonychia congenita type 4 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

KRT6B Gene Pachyonychia congenita type 4 NGS Genetic Test

Short Name: KRT6B PC Type 4 NGS Test

Also known as: PC type 4, KRT6B-related pachyonychia congenita, Pachyonychia congenita type IV

KRT6B Gene Pachyonychia congenita type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the KRT6B gene for accurate diagnosis of Pachyonychia congenita type 4, enabling personalized treatment and management strategies.

Test Code
5101
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

Clinical history of patient and genetic counseling session to draw a pedigree chart of affected family members.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

Your sample is analyzed using NGS (Next-Generation Sequencing) in our laboratory.

Step 3

Report Delivery

A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Blood or saliva sample collection for NGS analysis.
3
After the Test:Results interpretation and follow-up counseling.

About This Test

Who Should Get This Test

To identify mutations in the KRT6B gene for accurate diagnosis of Pachyonychia congenita type 4, enabling personalized treatment and management strategies.

How to Prepare

  • Provide a blood sample or saliva as per lab instructions
  • Ensure proper labeling and handling of sample

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for KRT6B mutations is essential for confirming diagnosis and enabling targeted management strategies for patients with Pachyonychia congenita type 4."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or saliva collection

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed blood sample
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the KRT6B gene.
📊

Positive for KRT6B mutation

Confirms diagnosis of Pachyonychia congenita type 4; genetic counseling recommended.

📊

Negative for KRT6B mutation

No pathogenic variant detected; consider other genetic causes or clinical evaluation.

⚠️ When to Consult a Doctor:

If you experience symptoms such as thickened nails, blistering, or calluses, or if there is a family history of pachyonychia congenita.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Requires genetic counseling for interpretation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA

Frequently Asked Questions

What is Pachyonychia congenita type 4?
Pachyonychia congenita type 4 is a rare genetic disorder caused by mutations in the KRT6B gene, leading to symptoms like thickened nails, blistering, and calluses.
What causes Pachyonychia congenita type 4?
It is caused by mutations in the KRT6B gene, which provides instructions for making keratin 6b protein essential for skin, nail, and hair development.
What are the symptoms of KRT6B gene mutation?
Symptoms include thickened nails, blistering, calluses on hands and feet, painful cysts, dental problems, difficulty walking, hoarseness, and swallowing difficulties.
How is the KRT6B Gene Test performed?
The test uses next-generation sequencing (NGS) to analyze a blood or saliva sample for mutations in the KRT6B gene.
What is the cost of the KRT6B Gene Test in India?
The cost is approximately INR 20,000 at DNA Labs India, with free home sample collection available.
Is home sample collection available for this test?
Yes, free home sample collection is available for online bookings across many cities in India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What should I do before taking the genetic test?
A genetic counseling session is recommended to discuss clinical history and draw a family pedigree chart.
Can this test be used for prenatal diagnosis?
This test is primarily for diagnostic purposes; prenatal testing may require specialized genetic counseling and different approaches.
What are the risks associated with the test?
Risks are minimal, such as bruising or infection from blood draw, but overall safe.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting gene mutations, but interpretation should be done by a genetic specialist.
What happens if the test is positive?
A positive result confirms diagnosis, and genetic counseling will guide management, treatment options, and family planning.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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