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KRT85 Gene Ectodermal dysplasia type 4, hair/nail type NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

KRT85 Gene Ectodermal dysplasia type 4, hair/nail type NGS Genetic Test

Short Name: KRT85 Ectodermal Dysplasia Type 4 Test

Also known as: Ectodermal dysplasia type 4, Hair/nail type ectodermal dysplasia, KRT85-related ectodermal dysplasia

KRT85 Gene Ectodermal dysplasia type 4, hair/nail type NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect pathogenic mutations in the KRT85 gene associated with ectodermal dysplasia type 4, hair/nail type, for diagnostic and counseling purposes.

Test Code
4904
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Provide clinical history and family pedigree.

Method: Venipuncture or finger-prick for FTA card

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling recommended to understand implications.
2
During the Test:Sample collection and processing in the lab.
3
After the Test:Report generation and counseling on results.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the KRT85 gene associated with ectodermal dysplasia type 4, hair/nail type, for diagnostic and counseling purposes.

How to Prepare

  • Ensure proper identification
  • Use sterile equipment
  • Label samples correctly

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is essential for confirming diagnosis in patients with suspected ectodermal dysplasia, enabling targeted management and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for NGS
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick for FTA card

Sample Stability

Room temperature24 hours
Refrigerated7 days
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the KRT85 gene. Positive results confirm diagnosis, while negative results may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of ectodermal dysplasia type 4

📊

No pathogenic variant detected

Unlikely to have KRT85-related disorder, but clinical correlation needed

📊

Variant of uncertain significance

Further testing or family studies recommended

⚠️ When to Consult a Doctor:

If you experience symptoms like sparse hair, brittle nails, or have a family history of ectodermal dysplasia, consult a geneticist or dermatologist for evaluation.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Variants of uncertain significance may be reported
  • ⚠Does not rule out other genetic disorders

Risks & Considerations

  • ●Minimal risk from blood draw
  • ●Possible bruising or infection at puncture site

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Technical errors in sequencing

Compare With Similar Tests

TestKRT85 Gene Ectodermal dysplasia type 4, hair/nail type NGS Genetic TestSanger SequencingWhole Exome Sequencing
ComparisonKRT85 Gene Ectodermal dysplasia type 4, hair/nail type NGS Genetic Test

Frequently Asked Questions

What is KRT85 Gene Ectodermal Dysplasia Type 4?
It is a rare genetic disorder caused by mutations in the KRT85 gene, affecting hair and nails, characterized by sparse hair, brittle nails, and skin abnormalities.
What are the symptoms of this disorder?
Symptoms include sparse or absent hair, brittle or malformed nails, and skin abnormalities such as dryness or scaling.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) technology to analyze the KRT85 gene for mutations from a blood or DNA sample.
What sample is required for the test?
A blood sample, extracted DNA, or one drop of blood on an FTA card is required.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What does a positive result mean?
A positive result confirms the presence of a pathogenic mutation in the KRT85 gene, diagnosing ectodermal dysplasia type 4.
What if the result is negative?
A negative result means no pathogenic variants were detected, but clinical correlation and further testing may be needed if symptoms persist.
Can this test be used for prenatal diagnosis?
This test is primarily for postnatal diagnosis; prenatal testing may require specialized genetic counseling and alternative methods.
Is genetic counseling recommended?
Yes, genetic counseling is recommended before and after testing to understand implications, inheritance patterns, and management options.
How accurate is the NGS genetic test?
NGS technology provides high accuracy for detecting mutations, but limitations exist, such as not detecting all variant types or reporting variants of uncertain significance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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