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LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic Test

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LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic Test

Short Name: LAMA5 Gene FSGS NGS Test

Also known as: LAMA5 Gene Test for FSGS, FSGS Genetic Panel, Laminin Alpha-5 Mutation Analysis

LAMA5 Gene Focal segmental glomerulosclerosis, LAMA5 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the LAMA5 gene associated with Focal Segmental Glomerulosclerosis, enabling early diagnosis, personalized treatment, and family risk assessment.

Test Code
5394
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree chart during genetic counseling.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or one drop on FTA card by trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site. Store sample as per instructions for stability.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling to discuss test implications and draw a family pedigree chart.
2
During the Test:Sample collection and processing in the laboratory using NGS technology.
3
After the Test:Report generation and delivery; follow-up with healthcare provider for result discussion.

About This Test

Who Should Get This Test

To identify mutations in the LAMA5 gene associated with Focal Segmental Glomerulosclerosis, enabling early diagnosis, personalized treatment, and family risk assessment.

How to Prepare

  • Ensure proper identification of patient
  • Use sterile collection tubes
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for LAMA5 mutations can aid in early diagnosis, personalized treatment, and family counseling for FSGS patients."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA Card

Sample Stability

Room TemperatureUp to 48 hours for blood; FTA card stable for longer
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient volume
  • Improper labeling
  • Contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the LAMA5 gene. A positive result suggests a genetic predisposition to FSGS, while a negative result does not exclude other causes.
📊

Pathogenic variant detected

Confirms genetic basis for FSGS; consider family screening and tailored management.

📊

No pathogenic variant detected

LAMA5 mutations unlikely; evaluate other genetic or non-genetic factors.

📊

Variant of uncertain significance

Further testing or clinical correlation needed.

⚠️ When to Consult a Doctor:

Consult a nephrologist if symptoms persist, worsen, or if genetic counseling is needed for family planning.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other causes of FSGS

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection, or discomfort

Interfering Factors

  • ●Poor sample quality
  • ●Contaminated DNA
  • ●Hemolyzed blood samples

Frequently Asked Questions

What is the LAMA5 Gene FSGS NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to identify mutations in the LAMA5 gene associated with Focal Segmental Glomerulosclerosis.
Why is this test recommended?
It is recommended for patients with symptoms of FSGS, family history of kidney disease, or unexplained proteinuria to identify a genetic cause.
What sample is required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
What is the cost of the test?
The test costs INR 20,000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities.
What do the results mean?
A positive result indicates a mutation in the LAMA5 gene linked to FSGS, while a negative result suggests no such mutation. Genetic counseling is advised.
Can this test diagnose FSGS definitively?
It identifies genetic mutations but should be correlated with clinical findings and other tests for diagnosis.
Are there any risks associated with the test?
The test involves a standard blood draw with minimal risks like bruising or infection.
How should I prepare for the test?
No special preparation is needed, but provide your clinical history and family pedigree during genetic counseling.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. DNA Labs India offers transparent pricing and reports.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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