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LAMB3 Gene Epidermolysis bullosa, junctional, non-Herlitz type NGS Genetic Test

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LAMB3 Gene Epidermolysis bullosa, junctional, non-Herlitz type NGS Genetic Test

Short Name: LAMB3 Gene EB Test

Also known as: Junctional Epidermolysis Bullosa Non-Herlitz Type, LAMB3-Related Epidermolysis Bullosa

LAMB3 Gene Epidermolysis bullosa, junctional, non-Herlitz type NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the LAMB3 gene for accurate diagnosis of junctional epidermolysis bullosa non-Herlitz type, aiding in prognosis and management.

Test Code
2405
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Genetic counseling recommended. Provide clinical history and family pedigree for accurate assessment.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected by a trained phlebotomist under aseptic conditions.

Step 3

Report Delivery

Sample transported to the lab for DNA extraction and sequencing analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule genetic counseling and provide detailed medical and family history.
2
During the Test:Blood sample collection is quick and minimally invasive.
3
After the Test:Wait for the report in 3-4 weeks; consult a doctor for interpretation and next steps.

About This Test

Who Should Get This Test

To identify mutations in the LAMB3 gene for accurate diagnosis of junctional epidermolysis bullosa non-Herlitz type, aiding in prognosis and management.

How to Prepare

  • Ensure proper labeling with patient details
  • Use sterile collection equipment
  • Avoid hemolysis during blood draw

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for LAMB3 mutations is essential for accurate diagnosis of junctional EB non-Herlitz type, enabling tailored management and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA Tube
Collection MethodVenipuncture

Sample Stability

Room Temperature24 hours
Refrigerated7 days
Sample Rejection Criteria:
  • Hemolyzed sample
  • Improperly labeled sample
  • Contaminated sample
  • Insufficient volume

Understanding Your Results

Results indicate the presence or absence of mutations in the LAMB3 gene associated with junctional EB non-Herlitz type.
📊

Pathogenic variant detected

Confirms diagnosis of LAMB3-related junctional EB non-Herlitz type

📊

No pathogenic variant detected

Does not rule out other forms of EB or genetic causes; further testing may be needed

⚠️ When to Consult a Doctor:

If you experience unexplained skin blistering, scarring, or have a family history of epidermolysis bullosa, consult a dermatologist or geneticist promptly.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires interpretation by a geneticist
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or discomfort

Interfering Factors

  • ●Contaminated DNA sample
  • ●Hemolyzed blood sample
  • ●Insufficient sample volume

Compare With Similar Tests

TestLAMB3 Gene Epidermolysis bullosa, junctional, non-Herlitz type NGS Genetic Test
ComparisonLAMB3 Gene Epidermolysis bullosa, junctional, non-Herlitz type NGS Genetic Test

Frequently Asked Questions

What is the LAMB3 Gene Epidermolysis Bullosa Test?
It is a genetic test using next-generation sequencing to detect mutations in the LAMB3 gene, which causes junctional EB non-Herlitz type.
What are the symptoms of junctional EB non-Herlitz type?
Symptoms include skin blistering, scarring, open sores, and potentially difficulty swallowing or breathing if mucous membranes are affected.
How is the test performed?
The test analyzes a blood or DNA sample using NGS technology to sequence the LAMB3 gene for mutations.
What is the cost of the test in India?
The test costs INR 20000 at DNA Labs India, with potential discounts for online bookings.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is fasting required for the test?
No, fasting is not required for this genetic test.
Can the test be done at home?
Yes, DNA Labs India offers free home sample collection in many cities across India.
What if the test result is positive?
A positive result confirms LAMB3-related junctional EB non-Herlitz type, and you should consult a geneticist for management and counseling.
Is genetic counseling necessary before testing?
Yes, genetic counseling is recommended to understand the test implications and draw a family pedigree.
How accurate is the NGS genetic test?
NGS technology provides high accuracy in detecting mutations, but results should be interpreted by a healthcare professional.
Are there any risks associated with the test?
The test involves minimal risks, such as bruising from the blood draw.
Where can I get this test done?
DNA Labs India provides this test with home collection available in numerous cities, including Mumbai, Delhi, Bangalore, and more.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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