LAMC1 Gene Pelvic organ prolapse, LAMC1 related NGS Genetic Test
Short Name: LAMC1 NGS POP
Also known as: LAMC1 Gene Sequencing, Pelvic Organ Prolapse Genetic Test, LAMC1 Mutation Analysis
LAMC1 Gene Pelvic organ prolapse, LAMC1 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect mutations in the LAMC1 gene that are associated with an increased risk of pelvic organ prolapse. It is intended for women with a family history of POP, early-onset POP, or recurrent prolapse after surgical repair. Genetic testing can confirm a hereditary component, inform reproductive decisions, and guide clinical management.
- Test Code
- 5896
- CPT Code
- 81479
- ICD Code
- N81.9
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before the test to discuss implications and family history.
Method: Venipuncture or FTA card blood spot
Laboratory Analysis
Blood sample is collected by a trained phlebotomist. For FTA card, a few drops of blood are placed on the card and allowed to dry.
Report Delivery
No restrictions. You can resume normal activities immediately.
Timeline: Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect mutations in the LAMC1 gene that are associated with an increased risk of pelvic organ prolapse. It is intended for women with a family history of POP, early-onset POP, or recurrent prolapse after surgical repair. Genetic testing can confirm a hereditary component, inform reproductive decisions, and guide clinical management.
How to Prepare
- Ensure the sample is labeled correctly with patient ID.
- For FTA card, allow blood spots to dry completely before packaging.
- Transport samples at ambient temperature.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Pelvic organ prolapse is multifactorial; genetic testing for LAMC1 mutations can help identify women at risk, enabling early intervention and family counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient blood volume
- Improperly labeled sample
- Sample received after prolonged transit without proper storage
Understanding Your Results
Positive (Pathogenic variant)
Confirms a genetic predisposition to pelvic organ prolapse. Recommend regular pelvic floor assessments and preventive measures.
Action: Consult a gynecologist and genetic counselor for management and family planning.
Negative (No pathogenic variant)
No genetic cause found in LAMC1. Pelvic organ prolapse may still occur due to other factors.
Action: Continue routine gynecological care and lifestyle modifications.
Variant of Uncertain Significance (VUS)
A genetic variant was found but its clinical significance is unknown.
Action: Further testing of family members may help clarify the variant's role.
Consult your healthcare provider if you experience symptoms such as pelvic pressure, a bulge in the vagina, urinary incontinence, or discomfort during intercourse. Also, if you have a family history of pelvic organ prolapse, discuss genetic testing options.
Limitations
- ⚠This test only analyzes the LAMC1 gene; other genetic causes of POP are not evaluated.
- ⚠A negative result does not rule out pelvic organ prolapse due to non-genetic factors.
- ⚠Variants of uncertain significance (VUS) may be reported; further family studies may be needed.
- ⚠This test is not intended for prenatal diagnosis.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic results
- ●Potential for incidental findings
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Recent blood transfusion (within 2 weeks)
- ●Bone marrow transplantation
- ●Insufficient sample quantity
Compare With Similar Tests
| Test | LAMC1 Gene Pelvic organ prolapse, LAMC1 related NGS Genetic Test | Whole Exome Sequencing (WES) | Targeted LAMC1 Single Gene Test | Pelvic Floor Disorder Panel |
|---|---|---|---|---|
| Comparison | LAMC1 Gene Pelvic organ prolapse, LAMC1 related NGS Genetic Test |
Frequently Asked Questions
What is the cost of the LAMC1 gene pelvic organ prolapse NGS genetic test?
What is the LAMC1 gene and how is it related to pelvic organ prolapse?
Who should consider this genetic test?
What sample is required for the test?
Do I need to fast before the test?
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Is home sample collection available?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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