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LEP Gene Obesity due to leptin deficiency NGS Genetic Test

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LEP Gene Obesity due to leptin deficiency NGS Genetic Test

Short Name: LEP Gene NGS Test

Also known as: Leptin Deficiency Genetic Test, LEP Gene Mutation Test, Obesity Genetic Test

LEP Gene Obesity due to leptin deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To detect mutations in the LEP gene that cause leptin deficiency and associated obesity, aiding in diagnosis and management.

Test Code
2631
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree.

Method: Venipuncture or saliva collection

Step 2

Laboratory Analysis

Blood draw or saliva collection performed by trained phlebotomist.

Step 3

Report Delivery

Apply pressure to puncture site. Store sample as instructed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Provide informed consent and clinical history.
2
During the Test:Sample collection procedure.
3
After the Test:Wait for results and follow-up consultation.

About This Test

Who Should Get This Test

To detect mutations in the LEP gene that cause leptin deficiency and associated obesity, aiding in diagnosis and management.

How to Prepare

  • Use sterile equipment
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This genetic test is essential for identifying leptin deficiency, a rare cause of obesity, especially in pediatric cases."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 ml blood or equivalent
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or saliva collection

Sample Stability

Blood: 48 hours at room temperature
DNA: Stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient volume
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the LEP gene.
📊

Positive

Pathogenic mutation detected, indicating leptin deficiency

📊

Negative

No mutations found, other causes should be considered

📊

Variant of uncertain significance

Requires further evaluation and genetic counseling

⚠️ When to Consult a Doctor:

If symptoms persist or genetic test is positive, consult an endocrinologist or geneticist.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Results require clinical correlation
  • ⚠Limited to LEP gene analysis

Risks & Considerations

  • ●Minimal risk from blood draw
  • ●Bruising or infection at puncture site

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample type

Frequently Asked Questions

What is the LEP Gene Obesity due to Leptin Deficiency NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to analyze the LEP gene for mutations causing leptin deficiency and obesity.
Why is this test important?
It helps diagnose a rare genetic condition that leads to severe obesity, enabling targeted treatment and management.
Who should get this test?
Individuals with symptoms like rapid weight gain in infancy, increased appetite, or family history of genetic obesity.
How is the test performed?
A blood or saliva sample is collected and analyzed using NGS technology to detect LEP gene mutations.
What is the cost of the test?
The cost is INR 20000, which includes sample collection, analysis, and report generation.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
What do the results mean?
Results indicate if pathogenic mutations are present, suggesting leptin deficiency, or if no mutations are found.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but serious complications are rare.
Can this test be used for prenatal diagnosis?
This test is typically for postnatal diagnosis; consult a geneticist for prenatal options.
What is leptin deficiency?
Leptin deficiency is a condition where the body does not produce enough leptin hormone, leading to uncontrolled appetite and obesity.
How is obesity due to leptin deficiency treated?
Treatment may include leptin replacement therapy, dietary management, and medical supervision under an endocrinologist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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