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LHB Gene Hypogonadotropic hypogonadism NGS Genetic Test

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LHB Gene Hypogonadotropic hypogonadism NGS Genetic Test

Short Name: LHB Gene HH NGS Test

Also known as: LHB Gene Test, Hypogonadotropic Hypogonadism Genetic Test, LH Beta Subunit Gene Test

LHB Gene Hypogonadotropic hypogonadism NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the LHB Gene Hypogonadotropic Hypogonadism NGS Genetic Test is to detect pathogenic mutations in the LHB gene that cause hypogonadotropic hypogonadism, aiding in accurate diagnosis, treatment planning, and genetic counseling for patients with symptoms of reproductive hormone deficiencies.

Test Code
5436
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree chart during genetic counseling.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or finger prick for FTA card. Ensure proper labeling and handling.

Step 3

Report Delivery

Apply pressure to the puncture site. Store samples as per instructions and transport to the lab promptly.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Undergo genetic counseling to discuss the test, provide clinical history, and draw a family pedigree chart. No fasting is required unless specified.
2
During the Test:A blood sample is collected from a vein or via a finger prick for FTA card. The procedure is quick and minimally invasive.
3
After the Test:Resume normal activities. Apply pressure to the collection site to prevent bruising. Results will be available in 3-4 weeks.

About This Test

Who Should Get This Test

The purpose of the LHB Gene Hypogonadotropic Hypogonadism NGS Genetic Test is to detect pathogenic mutations in the LHB gene that cause hypogonadotropic hypogonadism, aiding in accurate diagnosis, treatment planning, and genetic counseling for patients with symptoms of reproductive hormone deficiencies.

How to Prepare

  • Fast for 8-12 hours if specified, though not mandatory for this test
  • Avoid strenuous activity before sample collection
  • Inform the phlebotomist of any medications or recent procedures
  • Use sterile equipment and follow aseptic techniques

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS genetic test is essential for identifying LHB gene mutations causing hypogonadotropic hypogonadism, enabling targeted treatment and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Incorrect labeling or missing documentation
  • Contaminated samples

Understanding Your Results

Results from the LHB Gene NGS Genetic Test indicate the presence or absence of pathogenic mutations in the LHB gene. Positive results confirm a genetic cause for hypogonadotropic hypogonadism, while negative results suggest other etiologies may be involved.
📊

Negative

No pathogenic variants detected in the LHB gene. Consider other genetic or non-genetic causes of hypogonadotropic hypogonadism.

📊

Positive

Pathogenic variant(s) identified in the LHB gene, confirming a genetic diagnosis. Recommend genetic counseling and targeted treatment.

📊

Variant of Uncertain Significance (VUS)

A genetic variant was detected but its clinical significance is unknown. Further testing or family studies may be needed.

⚠️ When to Consult a Doctor:

Consult a healthcare professional if you experience symptoms of hypogonadotropic hypogonadism, such as delayed puberty, infertility, or sexual dysfunction, especially with a family history of the condition. After receiving test results, discuss them with a geneticist or endocrinologist for appropriate management.

Limitations

  • ⚠May not detect all genetic variants due to technical limitations
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other causes of hypogonadotropic hypogonadism
  • ⚠Turnaround time may vary based on sample quality

Risks & Considerations

  • ●Minor pain or bruising at the blood draw site
  • ●Rare risk of infection or fainting
  • ●No significant risks associated with genetic testing itself

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Recent blood transfusions
  • ●Improper sample storage

Frequently Asked Questions

What is the LHB Gene Hypogonadotropic Hypogonadism NGS Genetic Test?
This test uses next-generation sequencing to detect mutations in the LHB gene, which can cause hypogonadotropic hypogonadism, a condition leading to low sex hormones and reproductive issues.
Who should consider this test?
Individuals with symptoms like delayed puberty, infertility, or absent menstrual periods, especially with a family history of hypogonadotropic hypogonadism, should consider this test.
How is the test performed?
A blood sample or DNA extract is analyzed using NGS technology to sequence the LHB gene and identify any pathogenic mutations.
What is the cost of the test?
The test costs INR 20000.0, which includes home sample collection across India.
Is fasting required before the test?
No, fasting is not required for this genetic test, but follow any specific instructions from your healthcare provider.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do positive results mean?
Positive results indicate a pathogenic mutation in the LHB gene, confirming a genetic cause for hypogonadotropic hypogonadism. Genetic counseling is recommended.
What if the test is negative?
Negative results mean no pathogenic variants were detected in the LHB gene. Other genetic or non-genetic causes should be investigated.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
Can this test be used for prenatal diagnosis?
This test is primarily for diagnostic purposes in affected individuals. For prenatal testing, consult a genetic counselor for appropriate options.
What are the risks of the test?
The risks are minimal, mainly related to blood draw, such as slight pain or bruising. There are no significant risks from the genetic analysis itself.
How do I prepare for genetic counseling?
Gather your medical history and family pedigree information. A genetic counselor will guide you through the process and interpret results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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