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LIM2 Gene Cataract, Cortical Pulverulent, Late-Onset NGS Genetic Test

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LIM2 Gene Cataract, Cortical Pulverulent, Late-Onset NGS Genetic Test

Short Name: LIM2 Gene Cataract NGS

Also known as: LIM2 gene cataract NGS test, Cortical pulverulent cataract genetic test, Lens intrinsic membrane protein 2 gene test

LIM2 Gene Cataract, Cortical Pulverulent, Late-Onset NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The NGS genetic test report is available within 3 to 4 weeks from receipt of the sample at the laboratory.. Free home collection in 300+ cities across India.

OphthalmologyAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect pathogenic variants in the LIM2 gene and confirm the genetic basis of cortical pulverulent late-onset cataract. The result helps guide ophthalmological management, supports surgical decisions, and provides information for genetic counselling of the patient and at-risk family members.

Test Code
3791
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
The NGS genetic test report is available within 3 to 4 weeks from receipt of the sample at the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. A pre-test genetic counselling session is recommended to draw a pedigree chart of family members affected with LIM2 gene cataract and to discuss the benefits and limitations of the test.

Method: Venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

A blood sample is collected by a trained phlebotomist from a vein in the arm. Alternatively, one drop of blood may be collected on an FTA card, or an already extracted DNA sample may be submitted.

Step 3

Report Delivery

You may resume normal activities immediately. The sample is transported to the laboratory, and the report will be delivered within 3 to 4 weeks.

Timeline: The NGS genetic test report is available within 3 to 4 weeks from receipt of the sample at the laboratory.

Patient Instructions

1
Before the Test:A genetic counselling session is recommended before testing to draw a three-generation family pedigree, understand test limitations, and provide informed consent. No fasting is required.
2
During the Test:A small blood sample is collected from the arm, or a blood spot is placed on an FTA card. The procedure is quick and causes minimal discomfort.
3
After the Test:You can resume normal activities immediately. The sample is sent to the laboratory, and the report along with raw data files will be shared within 3 to 4 weeks.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect pathogenic variants in the LIM2 gene and confirm the genetic basis of cortical pulverulent late-onset cataract. The result helps guide ophthalmological management, supports surgical decisions, and provides information for genetic counselling of the patient and at-risk family members.

How to Prepare

  • No fasting required
  • Valid identity proof may be required at the time of sample collection
  • A genetic counselling session is recommended before testing
  • For FTA card collection, follow the instructions for proper blood spot application

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Ophthalmology assessment combined with NGS genetic testing helps identify the genetic cause of cortical pulverulent cataract and supports clinical management, surgical planning, and family counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA blood collection tube or FTA card
Collection MethodVenipuncture or FTA card blood spot

Sample Stability

EDTA blood: 24 to 48 hours at 2-8°C
Extracted DNA: stable for several months at -20°C
FTA card blood spot: stable at ambient temperature for several weeks
Sample Rejection Criteria:
  • Clotted or haemolysed blood sample
  • Insufficient sample quantity
  • Mislabeled or unlabeled sample
  • Sample severely degraded due to extreme temperature exposure

Understanding Your Results

The genetic test report must be interpreted by a clinical geneticist in the context of the patient's clinical history, ophthalmological examination, and family pedigree. Genetic counselling is recommended before and after testing.
Positive: Detection of a pathogenic or likely pathogenic variant in the LIM2 gene confirms a genetic cause of cortical pulverulent cataract.
Negative: Absence of a detectable pathogenic variant in the LIM2 gene reduces the likelihood of LIM2-related cataract but does not exclude other genetic or acquired causes.
Variant of Uncertain Significance: Variants that are not clearly benign or pathogenic may require additional family testing and clinical correlation.
Incidental findings: If clinically relevant secondary findings are identified, they will be handled as per laboratory policy and discussed during genetic counselling.
⚠️ When to Consult a Doctor:

If you experience blurred vision, night vision difficulty, glare, double vision, colour changes, or if you have a family history of hereditary cataract, consult an ophthalmologist and a clinical genetics specialist to discuss whether genetic testing is appropriate.

Limitations

  • ⚠This NGS test is limited to the LIM2 gene and may not detect mutations in other genes associated with hereditary cataract
  • ⚠Large structural rearrangements, deep intronic variants, or copy number variants may not be reliably detected by this NGS method
  • ⚠A negative result does not exclude mutations in other genes or non-genetic causes of cataract
  • ⚠A Variant of Uncertain Significance (VUS) may require additional family segregation studies

Risks & Considerations

  • ●No significant medical risks are associated with this genetic test
  • ●Mild pain or bruising may occur at the blood collection site
  • ●Rare local infection or haematoma at the venipuncture site

Interfering Factors

  • ●Inadequate quantity or quality of DNA may compromise NGS analysis
  • ●Sample degradation due to improper storage or transport
  • ●Variants located outside the targeted LIM2 gene regions are not evaluated
  • ●Laboratory error or sample mix-up, although minimised by strict protocols

Frequently Asked Questions

What is the cost of the LIM2 gene cataract NGS genetic test in India?
The cost of the LIM2 gene cataract cortical pulverulent late-onset NGS genetic test at DNA Labs India is approximately Rs 20000.
What does a mutation in the LIM2 gene cause?
A mutation in the LIM2 gene can cause cortical pulverulent cataract by affecting lens intrinsic membrane protein 2, which is needed to maintain lens transparency.
What are the symptoms of LIM2 gene cataract?
Symptoms include blurred or hazy vision, difficulty seeing at night, sensitivity to glare, double vision, and fading or yellowing of colours.
Is fasting required before the LIM2 gene NGS genetic test?
No, fasting is not required for this genetic test.
What sample types are accepted for this test?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted sample types for this test.
How long will the LIM2 gene NGS genetic test report take?
The report is generally delivered within 3 to 4 weeks after the sample is received by the laboratory.
Who should consider this LIM2 gene cataract NGS test?
Patients with clinical features of cortical pulverulent cataract, a family history of hereditary cataract, or those who wish to confirm a suspected LIM2 gene mutation should consider this test.
Will I receive raw data files with this genetic test?
Yes, DNA Labs India provides Raw Data, FASTQ, and VCF files along with the conclusive clinical report for transparency.
Does a negative test result exclude all types of cataract?
No, a negative result only means no pathogenic variant was detected in the LIM2 gene. Other genetic and non-genetic causes of cataract remain possible.
Is genetic counselling necessary before this test?
Yes, a genetic counselling session is recommended before testing to draw a pedigree chart and discuss the implications of the results.
Can this test help in family planning decisions?
The test can identify inherited risk in the family, and the results should be discussed with a genetic counsellor for reproductive planning and family risk assessment.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings for this test across many cities in India.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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