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LIPN Gene Ichthyosis, lamellar type 4 NGS Genetic Test

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LIPN Gene Ichthyosis, lamellar type 4 NGS Genetic Test

Short Name: LIPN Gene Ichthyosis Type 4 NGS Test

Also known as: Lamellar Ichthyosis Type 4, LIPN-Related Ichthyosis, Autosomal Recessive Lamellar Ichthyosis 4

LIPN Gene Ichthyosis, lamellar type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose LIPN gene mutations causing lamellar ichthyosis type 4, enabling accurate identification, management, and genetic counseling for affected individuals and families.

Test Code
2419
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Consult with a genetic counselor or dermatologist. Provide clinical history and family pedigree if available.

Step 2

Laboratory Analysis

Sample collection via venipuncture for blood or using FTA card for one drop blood. Ensure proper labeling and handling.

Step 3

Report Delivery

Store samples as per instructions. Await report delivery in 3-4 weeks and schedule follow-up consultation.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Schedule a consultation with a dermatologist or geneticist. Discuss symptoms, family history, and obtain a referral for genetic testing.
2
During the Test:Sample collection is quick and minimally invasive. A blood sample is drawn or a drop of blood is placed on an FTA card.
3
After the Test:Wait for the report, which will be delivered online. Follow up with your healthcare provider to discuss results and management options.

About This Test

Who Should Get This Test

To diagnose LIPN gene mutations causing lamellar ichthyosis type 4, enabling accurate identification, management, and genetic counseling for affected individuals and families.

How to Prepare

  • Use sterile equipment for blood collection
  • Label samples correctly with patient details
  • Transport samples at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for LIPN gene mutations is essential for accurate diagnosis and management of lamellar ichthyosis type 4, helping to tailor treatment and provide genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Test results indicate the presence or absence of pathogenic variants in the LIPN gene. Positive results confirm diagnosis of lamellar ichthyosis type 4, while negative results may require further testing.
Positive: Pathogenic variants detected, confirming LIPN gene mutation
Negative: No pathogenic variants detected, but clinical correlation needed
Variant of uncertain significance: Requires additional family studies or functional analysis
⚠️ When to Consult a Doctor:

If symptoms of lamellar ichthyosis are present, such as persistent dry and scaly skin, or if there is a family history of the condition. Consult a dermatologist or geneticist for evaluation and testing.

Limitations

  • ⚠May not detect all possible mutations in the LIPN gene
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Emotional impact of genetic results
  • ●Potential for uncertain results requiring further testing

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Insufficient DNA quantity

Frequently Asked Questions

What is LIPN Gene Ichthyosis, Lamellar Type 4?
It is a rare genetic skin disorder caused by mutations in the LIPN gene, leading to dry, scaly, and thickened skin from birth.
What are the common symptoms?
Symptoms include widespread scaling, thickened skin, nail abnormalities, hair loss, and painful skin cracks.
How is this condition diagnosed?
Diagnosis involves a physical examination by a dermatologist and confirmation through NGS genetic testing to identify LIPN gene mutations.
What is NGS Genetic Testing?
Next-Generation Sequencing (NGS) is a advanced genetic test that analyzes multiple genes simultaneously for comprehensive mutation detection.
What is the cost of the test at DNA Labs India?
The test costs INR 20,000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
How long does it take to get the report?
Reports are typically delivered within 3 to 4 weeks after sample collection.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted.
Is fasting required for the test?
No, fasting is not required for this genetic test.
Can insurance cover the cost of testing?
Insurance coverage varies; it is advisable to check with your provider. DNA Labs India offers transparent pricing.
What should I do if I have a family history of ichthyosis?
Consult a dermatologist or geneticist for evaluation and consider genetic testing for early diagnosis and counseling.
How can I interpret the test results?
Results should be interpreted by a healthcare professional. Positive results confirm LIPN gene mutations, while negative results may require further investigation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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