Liquid Bx. Cell Free KRAS Test
Short Name: Liquid Bx KRAS
Also known as: Cell-Free KRAS Mutation Test, Liquid Biopsy KRAS, ctDNA KRAS
Liquid Bx. Cell Free KRAS Test test available at DNA Labs India for ₹18,000. Uses Droplet Digital PCR on Peripheral Blood samples. Results in Results are typically available within 5-7 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Liquid Bx Cell Free KRAS test is to detect mutations in the KRAS gene from circulating tumor DNA in the blood. This helps in the early diagnosis of cancers, particularly colorectal, lung, and pancreatic cancers, and aids in selecting appropriate targeted therapies. It is also used to monitor treatment response and detect minimal residual disease or recurrence.
- Test Code
- 6115
- CPT Code
- 81479
- ICD Code
- Z12.9
- Price
- ₹18,000
- Sample Type
- Peripheral Blood
- Result Time
- Results are typically available within 5-7 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Droplet Digital PCR
Sample Collection
No special preparation is required. However, it is recommended to inform your doctor about any medications you are taking. A doctor's prescription is mandatory for this test.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist. The procedure is quick and minimally painful.
Report Delivery
You can resume your normal activities immediately. There are no restrictions after the test.
Timeline: Results are typically available within 5-7 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Liquid Bx Cell Free KRAS test is to detect mutations in the KRAS gene from circulating tumor DNA in the blood. This helps in the early diagnosis of cancers, particularly colorectal, lung, and pancreatic cancers, and aids in selecting appropriate targeted therapies. It is also used to monitor treatment response and detect minimal residual disease or recurrence.
How to Prepare
- Use Streck tube for blood collection
- Mix the blood gently by inverting the tube 8-10 times
- Do not centrifuge or freeze the sample
- Transport the sample to the laboratory within 24 hours at room temperature
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Liquid biopsy for KRAS mutations is a minimally invasive alternative to tissue biopsy, enabling real-time monitoring of tumor genetics and guiding targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Sample collected in EDTA tube instead of Streck tube
- Insufficient blood volume
- Sample received after more than 72 hours at room temperature
- Improper labeling or missing prescription
Understanding Your Results
No KRAS mutation detected
No evidence of KRAS-mutated tumor DNA in the blood. This may indicate absence of cancer or low ctDNA levels. Clinical correlation is advised.
KRAS mutation detected (e.g., G12D)
Presence of a KRAS mutation suggests the tumor may be resistant to EGFR inhibitors (e.g., cetuximab, panitumumab). Targeted therapy options may be limited; consider alternative treatments.
Consult your oncologist if you have symptoms such as unexplained weight loss, persistent cough, blood in stool or urine, or a family history of cancer. Also, discuss the results of this test with your doctor to understand their implications for your treatment plan.
Limitations
- ⚠Liquid biopsy may not detect all KRAS mutations due to low ctDNA concentration
- ⚠Results should be correlated with clinical and radiological findings
- ⚠Not a standalone diagnostic tool; tissue biopsy may still be required for initial diagnosis
- ⚠May not be covered by all insurance plans
- ⚠Requires a doctor's prescription
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection
- ●No radiation exposure
Interfering Factors
- ●Hemolysis or improper sample handling may degrade cell-free DNA
- ●Recent chemotherapy or radiation may reduce ctDNA levels
- ●Low tumor burden may lead to false-negative results
- ●Clonal hematopoiesis of indeterminate potential (CHIP) may cause false positives
- ●Sample collection in non-Streck tubes may affect DNA stability
Compare With Similar Tests
| Test | Liquid Bx. Cell Free KRAS | Liquid Bx Cell Free KRAS | Tissue Biopsy KRAS |
|---|---|---|---|
| Comparison | Liquid Bx. Cell Free KRAS |
Frequently Asked Questions
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