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LMNA Gene Hutchinson-Gilford progeria NGS Genetic Test

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LMNA Gene Hutchinson-Gilford progeria NGS Genetic Test

Short Name: LMNA Progeria NGS Test

Also known as: Progeria Genetic Test, LMNA Mutation Analysis, Hutchinson-Gilford Progeria Syndrome NGS Test

LMNA Gene Hutchinson-Gilford progeria NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the LMNA gene that cause Hutchinson-Gilford Progeria Syndrome, enabling early diagnosis and intervention.

Test Code
5783
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of family members affected with LMNA gene mutations.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or finger prick.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising and keep the area clean.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling to draw a pedigree chart of family members affected with LMNA gene mutations.
2
During the Test:The sample undergoes DNA extraction and NGS sequencing in the laboratory.
3
After the Test:Results are analyzed and a report is generated for review by a geneticist.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the LMNA gene that cause Hutchinson-Gilford Progeria Syndrome, enabling early diagnosis and intervention.

How to Prepare

  • Bring identification and prescription
  • Inform about any medications or health conditions
  • Follow any specific instructions from the genetic counselor

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for LMNA mutations is crucial for confirming progeria diagnosis and guiding management strategies."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml of blood or one drop on FTA card
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Blood samples stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the LMNA gene associated with Hutchinson-Gilford Progeria Syndrome.
Normal: No pathogenic variant detected, low risk for progeria
Abnormal: Pathogenic variant detected, confirmatory for progeria diagnosis
Variant of uncertain significance: Requires further testing and genetic counseling
⚠️ When to Consult a Doctor:

If genetic test results are abnormal or if symptoms of progeria are present, consult a geneticist or pediatrician.

Limitations

  • ⚠May not detect all types of LMNA mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Not a standalone diagnostic tool; clinical correlation needed

Risks & Considerations

  • ●Minimal risks from blood draw: bruising, infection, discomfort

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Technical errors in sequencing

Compare With Similar Tests

TestLMNA Gene Hutchinson-Gilford progeria NGS Genetic TestLMNA Gene Sanger SequencingWhole Exome SequencingProgeria Diagnostic Panel
ComparisonLMNA Gene Hutchinson-Gilford progeria NGS Genetic Test

Frequently Asked Questions

What is Hutchinson-Gilford Progeria Syndrome?
Hutchinson-Gilford Progeria Syndrome is a rare genetic disorder that causes rapid, premature aging in children, leading to a shortened lifespan.
What causes Hutchinson-Gilford Progeria Syndrome?
It is caused by a mutation in the LMNA gene, which produces lamin A protein essential for cell nucleus structure.
What are the common symptoms of progeria?
Symptoms include slow growth rate, baldness, prominent scalp veins, thin wrinkled skin, loss of body fat and muscle, stiff joints, high-pitched voice, and cardiovascular disease.
How is progeria diagnosed?
Diagnosis is based on physical symptoms and confirmed through genetic testing, such as NGS for LMNA gene mutations.
What is the LMNA gene and its role in progeria?
The LMNA gene encodes lamin A protein; mutations in this gene disrupt nuclear structure, leading to progeria symptoms.
What is NGS genetic testing?
Next Generation Sequencing (NGS) is a advanced genetic testing method that sequences DNA to detect mutations accurately.
How much does the LMNA Gene Progeria NGS Genetic Test cost?
The test costs INR 20000 at DNA Labs India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to receive the test results?
Results are typically available within 3 to 4 weeks.
What is the accuracy of the NGS genetic test for progeria?
NGS genetic testing is highly accurate for detecting LMNA gene mutations, but genetic counseling is recommended for interpretation.
Can Hutchinson-Gilford Progeria Syndrome be treated?
There is no cure, but early diagnosis can help manage symptoms and improve quality of life through supportive care.
Who should consider getting the LMNA Gene Progeria NGS Genetic Test?
Children with symptoms of premature aging or a family history of progeria should consider this test for early diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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