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LMNA Gene Lipodystrophy type 2, familial partial NGS Genetic Test

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LMNA Gene Lipodystrophy type 2, familial partial NGS Genetic Test

Also known as: Familial Partial Lipodystrophy Type 2, Dunnigan Syndrome

LMNA Gene Lipodystrophy type 2, familial partial NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)All Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the LMNA gene associated with familial partial lipodystrophy type 2, aiding in diagnosis, family screening, and management planning.

Test Code
2130
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide detailed clinical history and family pedigree. Genetic counseling session recommended.

Method: Venipuncture or DNA Extraction

Step 2

Laboratory Analysis

Blood draw or DNA extraction as per standard procedure.

Step 3

Report Delivery

Sample sent to lab for NGS analysis. Reports in 3-4 weeks.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Provide detailed clinical history and family pedigree. Genetic counseling session recommended.
2
During the Test:Sample collection as per instructions.
3
After the Test:Wait for report and follow up with physician.

About This Test

Who Should Get This Test

To identify mutations in the LMNA gene associated with familial partial lipodystrophy type 2, aiding in diagnosis, family screening, and management planning.

How to Prepare

  • Ensure proper sample labeling
  • Avoid hemolysis for blood samples
  • Store FTA card at room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for LMNA mutations can guide management of lipodystrophy and associated metabolic complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture or DNA Extraction

Sample Stability

Blood: 24 hours at room temperature
FTA Card: Stable at room temperature
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Incorrect sample type

Understanding Your Results

Genetic test results should be interpreted by a qualified geneticist in the context of clinical findings and family history.
Positive: Pathogenic LMNA mutation detected, confirming diagnosis
Negative: No mutation detected, but clinical suspicion remains, consider other tests
Variant of Uncertain Significance (VUS): Further evaluation needed
⚠️ When to Consult a Doctor:

Consult a geneticist or endocrinologist if symptoms of lipodystrophy are present or if there is a family history.

Limitations

  • ⚠May not detect all types of LMNA mutations
  • ⚠Requires genetic counseling for interpretation

Risks & Considerations

  • ●Bruising at puncture site
  • ●Infection risk (very low)

Interfering Factors

  • ●Sample degradation
  • ●Insufficient DNA quantity

Frequently Asked Questions

What is LMNA Gene Lipodystrophy Type 2?
LMNA Gene Lipodystrophy Type 2 is a rare genetic disorder caused by mutations in the LMNA gene, leading to abnormal fat distribution and metabolic complications such as insulin resistance and diabetes.
What are the symptoms of LMNA Gene Lipodystrophy Type 2?
Symptoms include loss of subcutaneous fat from limbs, buttocks, and trunk; fat accumulation in face, neck, and abdomen; insulin resistance, diabetes, high triglycerides, hypertension, and polycystic ovary syndrome in females.
How is LMNA Gene Lipodystrophy Type 2 diagnosed?
Diagnosis is based on clinical features, family history, and genetic testing. A physical exam, blood tests, and NGS genetic test to identify LMNA mutations are used.
What is the NGS Genetic Test for LMNA Gene?
Next-Generation Sequencing (NGS) is a genetic test that analyzes the LMNA gene to detect mutations associated with familial partial lipodystrophy type 2.
What is the cost of NGS Genetic Test in India?
The cost of NGS Genetic Test for LMNA Gene Lipodystrophy Type 2 in India is approximately INR 20,000, with home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across major cities in India.
What is the turnaround time for the test?
Reports are delivered within 3 to 4 weeks after sample collection.
Who should get tested for LMNA Gene Lipodystrophy Type 2?
Individuals with symptoms like abnormal fat distribution, insulin resistance, diabetes, or a family history of lipodystrophy should consider testing.
What are the treatment options after diagnosis?
Treatment focuses on managing symptoms, such as using medications for diabetes and high lipids, lifestyle changes, and regular monitoring by a healthcare team.
Is the test covered by insurance?
Coverage depends on the insurance provider; it is not typically covered under government schemes like PMJAY or CGHS, but check with your insurer.
How accurate is the NGS Genetic Test?
NGS is highly accurate for detecting LMNA mutations, but results should be interpreted by a geneticist alongside clinical findings.
Can the test detect all mutations in the LMNA gene?
The test may not detect all types of mutations, such as large deletions or deep intronic variants, and genetic counseling is recommended for interpretation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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