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LOXL1 Gene Exfoliation Syndrome, Susceptibility to NGS Genetic Test

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LOXL1 Gene Exfoliation Syndrome, Susceptibility to NGS Genetic Test

Short Name: LOXL1 NGS Genetic Test

Also known as: LOXL1 Genetic Test, Exfoliation Syndrome DNA Test, XFS Susceptibility Test

LOXL1 Gene Exfoliation Syndrome, Susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the LOXL1 Gene Exfoliation Syndrome NGS Genetic Test is to identify specific genetic variants in the LOXL1 gene that confer increased susceptibility to exfoliation syndrome and subsequent glaucoma. This test aids in risk assessment, early detection, and personalized management for individuals at risk.

Test Code
1480
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history and genetic counseling session recommended. No fasting required. Ensure proper identification and consent.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

Standard blood draw procedure using aseptic technique. Alternatively, use FTA card for drop blood.

Step 3

Report Delivery

Label samples correctly and transport at ambient room temperature. Process within stability window.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and family history assessment. No specific preparation required.
2
During the Test:Blood sample collection takes about 10-15 minutes.
3
After the Test:Resume normal activities. Monitor for any collection site reactions.

About This Test

Who Should Get This Test

The purpose of the LOXL1 Gene Exfoliation Syndrome NGS Genetic Test is to identify specific genetic variants in the LOXL1 gene that confer increased susceptibility to exfoliation syndrome and subsequent glaucoma. This test aids in risk assessment, early detection, and personalized management for individuals at risk.

How to Prepare

  • Collect blood in EDTA tube or apply one drop to FTA card
  • Ensure patient comfort and hygiene
  • Label samples with patient details
  • Avoid hemolysis during collection

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for LOXL1 variants can aid in proactive monitoring and management of exfoliation syndrome, potentially preventing glaucoma-related vision loss."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood in EDTA: stable for 48 hours at room temperature
FTA card: stable for weeks at room temperature if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrect labeling
  • Insufficient sample volume
  • Contaminated samples

Understanding Your Results

Results indicate the presence or absence of LOXL1 gene variants associated with exfoliation syndrome susceptibility. Positive results suggest increased genetic risk, requiring clinical evaluation and monitoring.
📊

Negative

No pathogenic LOXL1 variants detected. Standard risk for exfoliation syndrome based on genetics.

📊

Positive for risk variants

Increased genetic susceptibility to exfoliation syndrome. Recommend regular eye exams and monitoring by an ophthalmologist.

📊

Variant of uncertain significance

Further clinical correlation and possibly additional testing may be needed.

⚠️ When to Consult a Doctor:

Consult an ophthalmologist if genetic test is positive, symptoms like blurred vision or halos appear, or if there is a family history of glaucoma. Genetic counseling is advised for result interpretation.

Limitations

  • ⚠Genetic risk does not guarantee disease development
  • ⚠May not detect all rare variants
  • ⚠Results require clinical correlation
  • ⚠Predictive value varies by population

Risks & Considerations

  • ●Minor bruising or soreness at blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Hemolyzed blood samples
  • ●Incorrect sample collection or storage

Frequently Asked Questions

What is exfoliation syndrome?
Exfoliation syndrome is an eye disorder where abnormal fibrillar deposits accumulate in ocular tissues, increasing the risk of glaucoma and vision loss.
What is the LOXL1 gene?
The LOXL1 gene produces an enzyme involved in maintaining the extracellular matrix in the eye. Variants in this gene are linked to increased susceptibility to exfoliation syndrome.
Who should consider the LOXL1 genetic test?
Individuals with a family history of exfoliation syndrome or glaucoma, or those with symptoms like increased eye pressure or blurred vision.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) to analyze the LOXL1 gene from a blood sample or extracted DNA.
What does a positive result mean?
A positive result indicates genetic susceptibility to exfoliation syndrome, suggesting increased risk but not certainty of developing the condition. Regular eye monitoring is recommended.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort or bruising, but it is generally not painful.
How accurate is the genetic test?
The test is highly accurate for detecting known LOXL1 variants using advanced NGS technology, but results should be interpreted clinically.
What is the cost of the test?
The LOXL1 Gene Exfoliation Syndrome NGS Genetic Test costs INR 20,000 at DNA Labs India, inclusive of home collection and reporting.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for this test when booked online.
Can this test prevent glaucoma?
The test itself does not prevent glaucoma, but it identifies genetic risk, enabling early monitoring and intervention to manage exfoliation syndrome effectively.
Do I need genetic counseling?
Genetic counseling is recommended before and after testing to understand implications, interpret results, and plan follow-up care.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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