Manganese 24 Hour Urine Test
Short Name: Mn 24hr Urine
Also known as: Mn 24-Hour Urine Test, Urine Manganese Test, 24-Hour Urine Manganese, Manganese Excretion Test, Mn Urine Assay
Manganese 24 Hour Urine Test test available at DNA Labs India for ₹3,500. Uses ICP-MS (Inductively Coupled Plasma Mass Spectrometry) on 24-Hour Urine samples. Results in Sample collected daily; report available next working day after sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
This test is used to measure manganese levels in urine collected over a 24-hour period. It helps diagnose manganese toxicity from occupational or environmental exposure, monitor manganese levels in patients on long-term parenteral nutrition, evaluate manganese deficiency, and guide clinical management in patients with neurological symptoms potentially linked to manganese imbalance.
- Test Code
- 1210
- CPT Code
- 83785
- ICD Code
- R79.89
- Price
- ₹3,500
- Sample Type
- 24-Hour Urine
- Result Time
- Sample collected daily; report available next working day after sample receipt
- Fasting Required
- No
- Method
- ICP-MS (Inductively Coupled Plasma Mass Spectrometry)
Sample Collection
Refrain from taking vitamins, mineral, or herbal supplements for one week prior to specimen collection. If Gadolinium or Iodine-containing contrast media has been administered, wait at least 96 hours before collecting the specimen. Use only the acid-washed (metal-free) container kit provided. Use powderless gloves during specimen collection.
Method: 24-hour urine collection in acid-washed (metal-free) container; powderless gloves must be used during collection
Laboratory Analysis
Begin the 24-hour urine collection by discarding the first morning urine. Collect all subsequent urine over the next 24 hours, including the first urine of the final day. Mix the collected urine thoroughly. Transfer a 10 mL aliquot to the vial provided in the kit. Measure and record the total 24-hour urine volume on the vial and the test request form.
Report Delivery
Ship the specimen refrigerated or frozen. Ensure the sample container is properly labeled and sealed to prevent contamination or leakage.
Timeline: Sample collected daily; report available next working day after sample receipt
Patient Instructions
About This Test
Who Should Get This Test
This test is used to measure manganese levels in urine collected over a 24-hour period. It helps diagnose manganese toxicity from occupational or environmental exposure, monitor manganese levels in patients on long-term parenteral nutrition, evaluate manganese deficiency, and guide clinical management in patients with neurological symptoms potentially linked to manganese imbalance.
How to Prepare
- Obtain the acid-washed (metal-free) collection kit from the laboratory
- Discard the first morning urine on day 1; begin collecting all urine from that point forward
- Collect all urine for the next 24 hours, including the first morning urine on day 2
- Mix the entire 24-hour urine sample thoroughly
- Measure and record the total 24-hour urine volume on the container and test request form
- Transfer a 10 mL aliquot to the vial provided in the kit using powderless gloves
- Refrigerate the sample during the entire collection period
- Ship the specimen refrigerated or frozen to the laboratory
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The Manganese 24 Hour Urine Test is a valuable tool for assessing chronic manganese exposure, particularly in occupational and industrial settings. Unlike spot urine samples, a 24-hour collection provides a more accurate reflection of the body's total manganese excretion, helping clinicians evaluate both toxicity and deficiency states. This test is especially relevant for patients on long-term parenteral nutrition, welders, miners, and individuals with neurological symptoms that may be linked to environmental manganese exposure. Results should always be interpreted alongside clinical history, dietary intake, serum manganese levels, and imaging findings when appropriate."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Specimen collected in non-metal-free or non-acid-washed containers
- Contaminated specimen (visible metal particles or improper handling)
- Specimen collected within 96 hours of Gadolinium or Iodine contrast media administration
- Patient did not refrain from vitamin, mineral, or herbal supplements for one week prior to collection
- Incomplete 24-hour urine collection (missing intervals or significant volume loss)
- Specimen not shipped under proper temperature conditions (refrigerated or frozen)
Understanding Your Results
Manganese levels within the reference range suggest adequate manganese status with no significant evidence of toxicity or deficiency.
No intervention required. Continue routine monitoring if occupational exposure persists.
Elevated urinary manganese may indicate excessive manganese exposure, increased absorption, or release from body stores. This can be seen in occupational exposure (welding, mining), dietary excess, or manganese-containing supplement overuse.
Evaluate occupational and environmental exposure history. Correlate with serum manganese levels and neurological examination. Brain MRI may be warranted to assess for manganese deposition in the basal ganglia. Treatment involves removing the source of exposure and, in severe cases, chelation therapy.
Low urinary manganese may indicate manganese deficiency, which is rare but can occur with inadequate dietary intake, malabsorption syndromes, or in patients on prolonged parenteral nutrition without adequate supplementation.
Assess dietary manganese intake and underlying medical conditions. Consider supplementation under medical guidance. Monitor bone health, growth (in children), and wound healing.
Consult your doctor if your Manganese 24 Hour Urine Test results are outside the normal reference range, if you are experiencing symptoms such as fatigue, tremors, difficulty walking, muscle stiffness, headaches, speech difficulties, poor wound healing, joint pain, or if you have known occupational exposure to manganese. A healthcare professional can provide a comprehensive evaluation and recommend appropriate treatment.
Limitations
- ⚠Results reflect recent manganese excretion and may not fully represent total body manganese stores
- ⚠A single 24-hour urine collection may not capture day-to-day variability in manganese excretion
- ⚠Should be interpreted in conjunction with serum manganese levels, dietary history, and clinical symptoms
- ⚠Reference ranges may vary between laboratories; always interpret using the laboratory's own reference range
- ⚠Not a standalone diagnostic test for manganese toxicity; clinical correlation and imaging (e.g., brain MRI) may be required
Risks & Considerations
- ●No direct physical risk from the test procedure itself
- ●Risk of inaccurate results if specimen is collected improperly, contaminated, or if the 24-hour collection is incomplete
- ●Skin irritation may occur if urine is not handled properly; use of powderless gloves is recommended
Interfering Factors
- ●Vitamin, mineral, or herbal supplements taken within one week prior to specimen collection
- ●Recent administration of Gadolinium or Iodine-containing contrast media (specimen should not be collected for 96 hours after administration)
- ●Contamination of specimen with metal-containing materials during collection
- ●Incomplete 24-hour urine collection (under-collection or over-collection)
- ●Use of non-acid-washed or non-metal-free collection containers
Compare With Similar Tests
| Test | Manganese 24 Hour Urine Test | Manganese Serum Test | Manganese Whole Blood Test | Heavy Metal Panel – Urine |
|---|---|---|---|---|
| Comparison | Manganese 24 Hour Urine Test | Measures manganese concentration in blood at a single point in time. Useful for acute assessment but may not reflect long-term exposure as accurately as 24-hour urine collection. Cost may vary. | Assesses manganese levels in whole blood. Provides information on current manganese status but is subject to dietary influence from recent meals. Less commonly used than urine for monitoring chronic exposure. | Includes multiple heavy metals (lead, mercury, cadmium, arsenic, manganese) in a single 24-hour urine collection. Useful for comprehensive occupational screening but may not provide the same specificity for manganese as a dedicated Mn 24-hour urine test. |
Frequently Asked Questions
What is the Manganese 24 Hour Urine Test?
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Do I need to fast before the Manganese 24 Hour Urine Test?
What do elevated manganese levels in urine indicate?
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