MAP1A Gene Hearing loss, MAP1A related NGS Genetic Test
Short Name: MAP1A NGS Genetic Test
Also known as: MAP1A Deafness NGS Test, MAP1A Hereditary Hearing Loss Genetic Test, MAP1A Related Sensorineural Hearing Loss Test, MAP1A Gene Sequencing Test
MAP1A Gene Hearing loss, MAP1A related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Bioinformatics Pipeline Analysis, ACMG Variant Classification on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the MAP1A Gene Hearing Loss NGS Genetic Test is to detect pathogenic or likely pathogenic mutations in the MAP1A gene that may be responsible for hereditary sensorineural hearing loss. This test enables clinicians to establish a molecular diagnosis, differentiate genetic hearing loss from acquired causes, guide treatment and rehabilitation strategies, and provide accurate recurrence risk counseling for affected families.
- Test Code
- 2349
- CPT Code
- 81448
- ICD Code
- H90.3
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks from sample receipt at the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Bioinformatics Pipeline Analysis, ACMG Variant Classification
Sample Collection
No fasting is required. Inform the healthcare provider about any recent blood transfusions, current medications, and relevant family medical history. A pre-test genetic counseling session is recommended to draw a pedigree chart of family members affected with hearing loss.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect 3-5 mL of peripheral blood via venipuncture into an EDTA (lavender top) tube. Alternatively, extracted DNA or one drop of blood on an FTA card may be submitted.
Report Delivery
Apply pressure to the puncture site for 3-5 minutes. No specific post-collection restrictions are required. The sample will be transported to the laboratory under appropriate temperature-controlled conditions.
Timeline: Results are typically available within 3 to 4 weeks from sample receipt at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the MAP1A Gene Hearing Loss NGS Genetic Test is to detect pathogenic or likely pathogenic mutations in the MAP1A gene that may be responsible for hereditary sensorineural hearing loss. This test enables clinicians to establish a molecular diagnosis, differentiate genetic hearing loss from acquired causes, guide treatment and rehabilitation strategies, and provide accurate recurrence risk counseling for affected families.
How to Prepare
- Collect 3-5 mL peripheral blood in an EDTA (Lavender Top) tube.
- Alternatively, submit extracted DNA (minimum 200 ng) or one drop of blood on an FTA card.
- Label the sample clearly with patient name, date of birth, and unique identifier.
- Transport the sample at ambient room temperature (15-30°C).
- Ensure the sample reaches the laboratory within 48 hours of collection.
- Do not freeze whole blood samples.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Hearing loss with a suspected genetic etiology warrants molecular confirmation. The MAP1A gene has been implicated in hereditary sensorineural hearing loss, and NGS-based testing allows comprehensive analysis of the gene's coding region. Identifying a pathogenic variant can guide management decisions, inform prognosis, and enable accurate genetic counseling for affected families. I recommend this test for any patient presenting with unexplained bilateral sensorineural hearing loss and a positive family history consistent with autosomal dominant or recessive inheritance."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed blood sample
- Sample collected in incorrect tube type (non-EDTA)
- Insufficient sample volume
- Sample without proper labeling or identification
- Sample received beyond stability window
Understanding Your Results
No Pathogenic Variant Detected
No pathogenic or likely pathogenic variants were identified in the MAP1A gene. This result reduces the likelihood that the patient's hearing loss is caused by MAP1A mutations but does not exclude a genetic etiology entirely. Clinical correlation and consideration of additional genetic testing may be warranted.
Pathogenic or Likely Pathogenic Variant Detected
One or more pathogenic or likely pathogenic variants were identified in the MAP1A gene. This finding supports a molecular diagnosis of MAP1A-related hearing loss. Genetic counseling is recommended to discuss inheritance patterns, recurrence risks, and implications for family members.
Variant of Uncertain Significance (VUS) Detected
A variant of uncertain significance was identified. Currently, there is insufficient evidence to classify this variant as pathogenic or benign. The VUS should not be used for clinical decision-making. Periodic re-evaluation is recommended as new scientific data become available.
Consult your doctor or a clinical geneticist if you or a family member experiences unexplained hearing loss, especially if there is a family history of hearing impairment. You should also seek medical advice if you receive a positive result (pathogenic variant detected) or a VUS result, as further evaluation, family variant testing, and genetic counseling may be necessary.
Limitations
- ⚠This test analyzes only the MAP1A gene and does not screen for mutations in other hearing loss-associated genes unless specifically ordered.
- ⚠Deep intronic variants, large copy number variations (CNVs), and regulatory region mutations may not be fully detected by standard NGS sequencing.
- ⚠A negative result does not exclude a genetic cause of hearing loss as other genes may be involved.
- ⚠Variants of Uncertain Significance (VUS) may be reported and require periodic reclassification as new evidence becomes available.
Risks & Considerations
- ●Minor bruising or discomfort at the blood collection site
- ●Possibility of identifying Variants of Uncertain Significance (VUS) which may cause anxiety
- ●Psychological impact of positive genetic findings on patient and family members
Interfering Factors
- ●Degraded or insufficient DNA quality in the submitted sample
- ●Recent blood transfusion within the past 4 weeks may affect results
- ●Presence of hemoglobinopathies may impact DNA extraction quality
Compare With Similar Tests
| Test | MAP1A Gene Hearing loss, MAP1A related NGS Genetic Test | Sanger Sequencing for MAP1A | Comprehensive Hearing Loss Gene Panel (100+ genes) | Whole Exome Sequencing (WES) |
|---|---|---|---|---|
| Comparison | MAP1A Gene Hearing loss, MAP1A related NGS Genetic Test |
Frequently Asked Questions
What is the MAP1A Gene Hearing Loss NGS Genetic Test?
Who should consider getting tested for MAP1A gene mutations?
What sample type is required for the MAP1A NGS Genetic Test?
How long does it take to receive the test results?
What is the cost of the MAP1A NGS Genetic Test in India?
Is home sample collection available for this test?
What does a positive (pathogenic variant detected) result mean?
Can this test detect all genetic causes of hearing loss?
Is genetic counseling recommended before and after this test?
Does DNA Labs India provide raw data files with the test report?
Is the MAP1A Gene NGS Genetic Test covered by insurance?
What are the limitations of the MAP1A NGS Genetic Test?
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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