MeDIP-Seq Library Preparation Test
Short Name: MeDIP-Seq Library Prep
Also known as: Methylated DNA Immunoprecipitation Sequencing Library Preparation, MeDIP-seq Library Kit
MeDIP-Seq Library Preparation Test test available at DNA Labs India for ₹12,000. Uses MeDIP-Seq (Methylated DNA Immunoprecipitation followed by Next-Generation Sequencing) on Extracted DNA samples. Results in Reports are typically available within 12 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of MeDIP-Seq library preparation is to generate a sequencing-ready library that accurately represents the methylated regions of the genome. This allows for the identification of differentially methylated regions (DMRs) associated with various diseases, developmental stages, or environmental exposures. It is used in research and clinical settings to study epigenetic biomarkers, drug response, and disease prognosis.
- Test Code
- 6375
- CPT Code
- Not applicable
- ICD Code
- Not applicable
- Price
- ₹12,000
- Sample Type
- Extracted DNA
- Result Time
- Reports are typically available within 12 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- MeDIP-Seq (Methylated DNA Immunoprecipitation followed by Next-Generation Sequencing)
Sample Collection
Ensure that the DNA sample is extracted using a validated method and is free from contaminants. The sample should be shipped on dry ice to maintain integrity.
Method: Blood or tissue sample for DNA extraction
Laboratory Analysis
No special precautions required for the patient as the test is performed on extracted DNA. For blood collection, standard venipuncture is performed.
Report Delivery
The DNA sample should be stored at -20°C or below until shipment. Avoid repeated freeze-thaw cycles.
Timeline: Reports are typically available within 12 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of MeDIP-Seq library preparation is to generate a sequencing-ready library that accurately represents the methylated regions of the genome. This allows for the identification of differentially methylated regions (DMRs) associated with various diseases, developmental stages, or environmental exposures. It is used in research and clinical settings to study epigenetic biomarkers, drug response, and disease prognosis.
How to Prepare
- Provide the extracted DNA sample in a sterile, nuclease-free tube.
- Label the tube with patient ID and sample type.
- Ship the sample on dry ice to the laboratory.
- Include a requisition form with relevant clinical details.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"MeDIP-Seq is a powerful tool for studying epigenetic changes in cancer and developmental disorders. Accurate library preparation is critical for reliable methylation profiling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- DNA concentration below 10 ng/µL
- DNA degraded (fragment size < 1 kb)
- Sample contaminated with protein or RNA
- Sample not shipped on dry ice
- Insufficient volume
Understanding Your Results
Consult a geneticist or oncologist if you are considering MeDIP-Seq for clinical diagnosis or research. They can help interpret results and guide further testing.
Limitations
- ⚠Requires high-quality DNA; degraded samples may yield poor results
- ⚠Does not provide single-base resolution (unlike bisulfite sequencing)
- ⚠Antibody specificity may affect enrichment efficiency
- ⚠Bioinformatics analysis requires expertise
- ⚠Not suitable for formalin-fixed paraffin-embedded (FFPE) samples with heavy cross-linking
Risks & Considerations
- ●No direct risks to the patient as the test is performed on extracted DNA.
- ●For blood collection, minimal risks of bruising or infection at the puncture site.
Interfering Factors
- ●Poor DNA quality or degradation
- ●Contamination with RNA or proteins
- ●Incomplete fragmentation
- ●Insufficient antibody binding
- ●PCR amplification bias
- ●Batch effects in sequencing
Compare With Similar Tests
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| Comparison | MeDIP-Seq Library Preparation |
Frequently Asked Questions
What is MeDIP-Seq?
What is the cost of MeDIP-Seq library preparation at DNA Labs India?
What sample type is required for MeDIP-Seq?
How long does it take to get results?
Is home sample collection available?
What is the turnaround time for MeDIP-Seq?
What are the quality control measures for MeDIP-Seq library preparation?
Can MeDIP-Seq be used for clinical diagnosis?
What is the difference between MeDIP-Seq and bisulfite sequencing?
What is the minimum DNA amount required?
Does the test require fasting?
How should the DNA sample be shipped?
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